# of Displayed Technologies: 6 / 6

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Transdermal Drug and Gene Therapy Delivery
TS-045224 — A new modality for delivering drugs and gene therapies.
Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight disease. These next-generation treatments hold promise for treating various genetic and chronic diseases, including but not limited to cancer, cystic fibr…
  • College: College of Medicine (COM)
  • Inventors: Gallego Perez, Daniel; Higuita Castro, Natalia; Johnson, Jed; Ohst, Devan
  • Licensing Officer: Csatary, Erika

Multi-Functional Drug Delivery Nanodevice for Precision Medicine
TS-041485 — A functionalized DNA nanostructure made through a scaffolded DNA origami molecular self-assembly process to deliver clinically significant concentrations of therapeutics.
This novel therapeutic approach leverages structural nanotechnology to create a DNA nanostructure that acts as a customizable delivery vehicle for therapeutic molecules. The technology allows for a highly tunable and customizable multi-functional drug delivery platform that incorporates interchang…
  • College: College of Engineering (COE)
  • Inventors: Castro, Carlos; Byrd, John; Halley, Patrick; Lucas, Christopher
  • Licensing Officer: He, Panqing

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"

Development of STAT3 dimerization inhibitors for cancers
TS-037569 — The constant activation of Signal Transducer and Activator of Transcription 3 (STAT3) is frequently detected in many cancer patients with advanced diseases. About 80% of all cancers overexpress STAT3, including solid tumors, lymphoma, and leukemia. Constant activation of STAT3 activities in nonmal…
  • College: College of Pharmacy
  • Inventors: Li, Pui-Kai "Tom"; Li, Chenglong; Lin, Jiayuh
  • Licensing Officer: He, Panqing

Biomimetic Nanoplatform to Deliver Anti-Restenotic Therapeutics
TS-036654 — A stent-free delivery platform for reducing arterial plaques.
Cardiovascular disease is the leading cause of death in the United States, resulting in more than 600,000 deaths and a significant contributor to overall healthcare costs. Over 28 million Americans are diagnosed with heart disease and contribute more than $30 billion in healthcare-related expenses. …
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Urabe, Go; Wang, Bowen
  • Licensing Officer: Csatary, Erika

Self-Assembly of Therapeutic-Agent Nanostructures
TS-014812 — An improved delivery mechanism has been developed for hydrophobic drugs such as camptothecin which will increase chemotherapeutic efficacy.
Many cancer therapeutics exhibit extremely toxic side effects or have limited efficacy due to low bio-availability. Existing drug delivery technologies can add excessive mass to the therapeutic, grossly expanding the dosage necessary for response. Camptothecin (CPT) is a naturally occurring compou…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Grinstaff, Mark; Kaplan, Jonah; Kim, Se Hye
  • Licensing Officer: Willson, Christopher

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