Available Technologies
# of Displayed Technologies: 10 / 20
Applied Category Filter (Click To Remove): Drug Delivery
Fibroblast-specific LNPs delivering A20 mRNA to treat idiopathic pulmonary fibrosis (IPF)
TS-075175 — Problem
Idiopathic pulmonary fibrosis (IPF) is a chronic disease where activated fibroblasts mediate the abnormal accumulation of extracellular matrix (ECM) in the lung interstitial space, leading to progressive impairment of pulmonary function. Current IPF therapies are associated with significant…
- College: College of Pharmacy (COP)
- Inventors: Dong, Yizhou; Kang, Diana; Wang, Chang; Yan, Jingyue
- Licensing Officer: He, Panqing
Vitrectomy and Insulin Assisted Retinal Gene Therapy
TS-075164 — The Problem
Treatments for inherited retinal diseases are currently limited. Gene therapy has emerged as a strong treatment option. However, difficulties have arisen with these gene therapies. It has been found that an intrathecal injection of adenoassociated viral (AAV) gene therapy vector does no…
- College: College of Medicine (COM)
- Inventors: Mendel, Thomas; Kaur, Sukhvinder
- Licensing Officer: Willson, Christopher
Novel extracellular vesicles loaded with anti-inflammatory agents for the treatment of pulmonary diseases
TS-075161 — Problem
Acute and chronic pulmonary inflammation conditions, such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI) and asthma, remain a significant healthcare challenge with high mortality rates, long-term morbidity and a substantial economic burden due to prolonged hospital s…
- College: College of Medicine (COM)
- Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
- Licensing Officer: Willson, Christopher
Cyclic Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-073895 — The Need
In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Cell-penetrating peptides (CPPs) initially were considered a potential solution. Short sequences of amino acid…
- College: College of Arts and Sciences (COAAS)
- Inventors: Pei, Dehua
- Licensing Officer: Dahlman, Jason "Jay"
Strain‑Activated Programmable Surfaces for Controlled Drug Delivery in Mechanically Regulated Diseases
TS-072945 —
Many mechanically mediated conditions such as vascular hypertension, glaucoma, and abdominal distension, present intermittent, unpredictable episodes that demand drug release only when symptoms emerge. Conventional platforms often leak at baseline, require external triggers, or cannot synchronize …
- College: College of Engineering (COE)
- Inventors: Zhao, Yi
- Licensing Officer: Randhawa, Davinder
Breakthrough In Delivery: Expanding Access to Intracellular Targets for Next-Generation Therapies
TS-072004 — Empower your pipeline with a versatile platform for efficient, customizable biomolecule transport.
Overview
Intracellular delivery remains a persistent challenge in drug delivery, gene editing, and biotechnology. Pharmaceutical and biotech companies lose valuable opportunities when promising drugs and biologics cannot reach their intended targets inside cells, limiting product effectiveness and m…
- College: College of Arts and Sciences (COAAS)
- Inventors: Bong, Dennis
- Licensing Officer: Panic, Ana
Cyclic Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-066751 — The Need
In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Cell-penetrating peptides (CPPs) initially were considered a potential solution. Short sequences of amino acid…
- College: College of Arts and Sciences (COAAS)
- Inventors: Pei, Dehua
- Licensing Officer: Dahlman, Jason "Jay"
Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide.
The Need
Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
- College: College of Engineering (COE)
- Inventors: Purmessur Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
- Licensing Officer: Willson, Christopher
Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — , 2018-345 Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need
Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
- College: College of Medicine (COM)
- Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
- Licensing Officer: Willson, Christopher
Advanced AAV Gene Therapy Characterization Technique
TS-062608 — Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight infection. These next-generation treatments hold promise for treating various genetic and chronic conditions, including but not limited to cancer, cystic …
- College: College of Arts and Sciences (COAAS)
- Inventors: Wysocki, Vicki; Cleary, Sean; Du, Chen
- Licensing Officer: Dahlman, Jason "Jay"
