The Need: Colorectal cancer remains a significant global health challenge, particularly when it metastasizes to the liver. Accurate and rapid diagnosis of metastatic liver lesions is crucial for effective treatment planning and patient outcomes. Traditional diagnostic methods often lack the specificity and speed required for timely interventions, highlighting the pressing need for innovative technologies that can enhance detection accuracy while streamlining clinical workflows.

The Technology: The Colorectal Cancer to Metastatic Liver infrared library (CCML) is a groundbreaking resource that leverages infrared imaging Fourier transform spectra (FTIR) of frozen tissue sections from patients with liver metastasis of colorectal origin. Developed through rigorous research at the University Hospital (Ohio State University, Columbus, OH), this library comprises 756,096 full-range IR spectra. Utilizing support vector machine (SVM) decision equations trained on a subset of spectra, the CCML enables precise tumor-nontumor classifications. Additionally, an accompanying document provides comprehensive guidance on accessing the library for research and designing fast IR cancer probes with enhanced wavenumber range and step resolution.

Commercial Applications:

• Precision oncology: Facilitates accurate classification of colorectal cancer metastases in liver tissue, aiding personalized treatment strategies.
• Biomedical research: Supports advanced studies on colorectal cancer metastasis mechanisms and therapeutic interventions.
• Pharmaceutical development: Enables high-throughput screening of potential anticancer compounds targeting liver metastases, expediting drug discovery processes.

Benefits/Advantages:

• Enhanced diagnostic accuracy: Empowers clinicians with a sophisticated tool for differentiating tumor from non-tumor liver tissue, minimizing diagnostic errors.
• Accelerated research insights: Streamlines data analysis and interpretation, enabling researchers to extract meaningful insights from complex IR spectra efficiently.
• Improved treatment outcomes: Facilitates tailored therapeutic approaches by providing clinicians with reliable molecular information on colorectal cancer metastases, leading to optimized patient care.