Available Technologies
# of Displayed Technologies: 10 / 14
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Multimeric Notch ligands based on IgM-like fusion molecular structures for activation of ligand-specific Notch signaling
TS-064248 —
The Notch signaling pathway is important in immune cell differentiation and maturation. As a result, it has been shown that Notch receptor signaling can promote or suppress adaptive immune responses depending on the particular ligands and receptors involved. A set of native protein-inspired biolog…
- College: OSU Wexner Medical Center
- Inventors: Dikov, Mikhail; Carbone, David; Goruganthu, Uttam Lakshmi Mounika; Tchekneva, Elena
- Licensing Officer: Willson, Christopher
Novel STK1-targeted small molecule "antibiotic resistance breaker" compounds
TS-063547 — Novel small molecule STK1 inhibitors that “break” the resistance of bacteria strains to antibiotics.
In today’s healthcare landscape, increasingly highly pathogenic and multidrug-resistant S. aureus (MDRSA) strains are replacing traditional methicillin-resistant S. aureus (MRSA) in both community and hospital settings.
The Need
The rise of these resilient multi-drug resistant bacteria has …
- College: College of Medicine (COM)
- Inventors: Pancholi, Vijay
- Licensing Officer: Willson, Christopher
Novel use of novobiocin to potentiate the antimicrobial efficacy of polymyxins
TS-062439 — The Need: Addressing the Growing Threat of Gram-Negative Bacterial Infections
Gram-negative bacterial pathogens, including Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, are responsible for more than 35% of common hospital-acquired infections. These no…
- College: College of Arts & Sciences
- Inventors: Kahne, Daniel; Baidin, Vadim; Mandler, Michael; Ruiz, Natividad
- Licensing Officer: Dahlman, Jason "Jay"
A novel VSV-based vaccine platform for Zika virus
TS-062261 — The Need: Addressing the Zika Virus Outbreak
The Zika virus outbreak, which started in South America and quickly became a global public health issue, has led to severe neurological disorders, birth defects, and other health complications in affected populations. Despite efforts to combat the virus,…
- College: College of Medicine (COM)
- Inventors: Peeples, Mark; Li, Jianrong
- Licensing Officer: Bhatti, Hamid
FraB as a drug target and FraB inhibitors as Salmonella-specific narrow-spectrum therapeutics
TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.
Non-typhoidal salmonellosis is one of the most significant food-borne diseases, in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics available to treat the disease. However, antibiotic resistance is on the ris…
- College: College of Medicine (COM)
- Inventors: Ahmer, Brian; Boulanger, Erin; Cool, Austin; Gopalan, Venkat; Kovvali, Sai Sravya Varali; Law, Jamison; Lindert, Steffen; Sabag-Daigle, Anice; Sengupta, Anindita; Thirugnanasambantham, Pankajavalli
- Licensing Officer: Willson, Christopher
Development of a live attenuated vaccine for leishmaniasis using CRISPR technology
TS-051167 — Methods of production and use of modified Leishmania species and compositions of live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions.
Leishmaniasis is a neglected tropical disease caused by infection with protozoans of the 15 genus Leishmania that is transmitted by infected sand flies. Worldwide, an estimated 1 billion people are at risk of infection in tropical and subtropical countries, with up to 1.7 million new cases in 98 c…
- College: College of Medicine (COM)
- Inventors: Satoskar, Abhay
- Licensing Officer: Willson, Christopher
Live vaccine candidate for Chagas disease
TS-044084 —
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
- College: College of Medicine (COM)
- Inventors: McGwire, Bradford
- Licensing Officer: He, Panqing
AR-12 for the Treatment of Leishmaniasis (Protozoa)
TS-041764 — AR-12 is a FDA-IND approved small molecule that has been repurposed to treat leishmaniasis, a parasitic infection.
Leishmaniasis is a protozoal parasitic disease transmitted by sandflies. The disease affects millions of people worldwide. Sandflies carrying the promastigote form of the parasite bite a human host, attracting macrophages to the site of the wound. Promastigotes are then phagocytized by the macroph…
- College: College of Medicine (COM)
- Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Gautam, Shalini; Peine, Kevin
- Licensing Officer: Willson, Christopher
A Small Molecule That Disperses Salmonella Biofilms
TS-041469 — A new compound to eliminate Salmonella biofilms to reduce typhoid fever.
The bacterium Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever – infecting and killing an estimated 21 million and 200,000 individuals each year, respectively. Individuals contract the disease by consuming food or water contaminated with the etiologic agent …
- College: College of Medicine (COM)
- Inventors: Gunn, John; Huggins, William; Kuo, Laura; Melander, Christian
- Licensing Officer: Taysavang, Panya
Novel Immunomodulators and Vaccine Adjuvants
TS-038032 — A class of compounds possessing potent immunomodulatory activity, to enhance the protection of vaccines against infectious agents.
While vaccines are commonly used today for a variety of diseases and have proven efficacious for disease prevention, some vaccines do not efficiently activate an immune response. About 10% of vaccinations fail to mount adequate antibody levels to routine vaccinations. Also, many viruses rapidly mu…
- College: College of Medicine (COM)
- Inventors: Satoskar, Abhay; Ainslie, Kristy; Bachelder, Eric; Fuchs, James; Kinghorn, Alan "Dr. A. Douglas Kinghorn"; Parinandi, Narasimham
- Licensing Officer: Willson, Christopher
