Available Technologies
# of Displayed Technologies: 10 / 111
Applied Category Filter (Click To Remove): Therapeutics
Breakthrough In Delivery: Expanding Access to Intracellular Targets for Next-Generation Therapies
TS-072004 — Empower your pipeline with a versatile platform for efficient, customizable biomolecule transport.
Overview
Intracellular delivery remains a persistent challenge in drug delivery, gene editing, and biotechnology. Pharmaceutical and biotech companies lose valuable opportunities when promising drugs and biologics cannot reach their intended targets inside cells, limiting product effectiveness and m…
- College: College of Arts & Sciences
- Inventors: Bong, Dennis
- Licensing Officer: Panic, Ana
Smart Blueberry Extract: The Modern Natural Health Solution for Inflammation Relief and Wellness
TS-071830 — Unlocking plant-powered solutions to deliver effective inflammation relief and enhance disease outcomes.
Overview
Chronic inflammation driven by elevated interleukin-11 (IL-11) is a critical underlying cause of tissue scarring and cancer, worsening the disease outcomes over time. Current anti-inflammatory options fall short, offering limited control over IL-11 and failing to stop its persistent buildu…
- College: College of Food, Agricultural, and Environmental Sciences (CFAES)
- Inventors: Giusti, M. Monica; Prasher, Harmeen; Sellers, Patrick; Ziouzenkova, Ouliana
- Licensing Officer: Panic, Ana
A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need
The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
- College: College of Arts & Sciences
- Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
- Licensing Officer: Panic, Ana
Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab
Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
- College: College of Engineering (COE)
- Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
- Licensing Officer: Schworer, Adam
Revolutionizing Corneal Repair: Advanced MG53-Based Treatment for Enhanced Ocular Health
TS-066878 — New and more effective treatments for corneal injuries.
Current treatments for corneal injuries often have side effects that can compromise vision, highlighting the need for a new method that enhances ocular tissue repair without such drawbacks.
The Need
Injuries to the cornea can lead to severe pain, infection, and vision loss due to scarring and abno…
- College: College of Optometry
- Inventors: Chandler, Heather; Ma, Jianjie; Tan, Tao; Zhu, Hua
- Licensing Officer: Schultz, Teri
Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need
Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
- College: College of Medicine (COM)
- Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
- Licensing Officer: Willson, Christopher
Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-066751 —
In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Traditional methods face challenges with membrane impermeability and degradation of therapeutic compounds, limiting th…
- College: College of Arts & Sciences
- Inventors: Pei, Dehua
- Licensing Officer: Dahlman, Jason "Jay"
Innovative Small Molecule Inhibitors for Effective Treatment and Prevention of Coronavirus Infections
TS-066750 —
The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global health and economies. Despite vaccine efforts, issues such as vaccine hesitancy, delays in distribution, and emerging variants have highlighted the need for effective therapeutic interventions. These i…
- College: College of Veterinary Medicine
- Inventors: Sharma, Amit; Li, Pui-Kai "Tom"; Xing, Enming
- Licensing Officer: Willson, Christopher
MG53: Enhancing Tissue Performance and Repairing Damaged Tissue
TS-066191 — , T2019-164, T2020-002, T2020-159, T2020-222: Using rhMG53 to treat conditions involving damaged tissue, including corneal repair, hepatic tissue injury, inflammatory bowel disease, and other tissue injury.
The Need
While MG53 is naturally present in skeletal and cardiac muscle, its levels are often insufficient to optimize tissue performance. Current treatments leveraging exogenous MG53 are therapeutically ineffective for conditions like multiple sclerosis, viral infections, radiation-induced tissue …
- College: College of Medicine (COM)
- Inventors: Ma, Jianjie; Tan, Tao; Zhu, Hua
- Licensing Officer: Schultz, Teri
Innovative Solutions for Cell Viability and Targeted Delivery
TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications
The Need:
Conventional electroporation methods often result in low cell viability due to heat generation, especially when working with primary cells. These methods also face challenges with non-specific transport of molecules, high vector integration rates leading to mutagenesis, and inefficacy in …
- College: College of Engineering (COE)
- Inventors: Gallego Perez, Daniel; Das, Devleena; Duarte Sanmiguel, Silvia; Higuita Castro, Natalia
- Licensing Officer: Willson, Christopher
