A new modular format for bispecific antibody fragments
TS-068425 — Functionalization
of scFvs with cyclic peptide linkers
The Need
The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
- College: College
of
Arts
&
Sciences
- Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
- Licensing Officer: Panic, Ana
Noninvasive Rapid Radiation Exposure Assay
TS-068290 — The Need
Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require invasive procedures and may not detect exposure at lower dose ranges.
…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Jacob, Naduparambil; Morder, Courtney; Witte, Spencer
- Licensing Officer: Panic, Ana
RAFT Agents for Controlled Radical Polymerization of Biofunctionalized Polymeric Materials
TS-068081 — These RAFT agents enable synthesis
of novel polymer materials with enhanced biocompatibility and tailored functionality, suited for a wide range
of biomedical applications.
Background
The growing demand for biofunctionalized polymer materials in fields such as drug delivery and diagnostics requires precise control over polymer properties. However, current reagents for Reversible Addition Fragmentation chain Transfer (RAFT) polymerization struggle with achieving the ne…
- College: College
of
Arts
&
Sciences
- Inventors: Kulkarni, Anuja; Watkins, Davita
- Licensing Officer: Panic, Ana
Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-066751 —
In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Traditional methods face challenges with membrane impermeability and degradation of therapeutic compounds, limiting th…
- College: College
of
Arts
&
Sciences
- Inventors: Pei, Dehua
- Licensing Officer: Dahlman, Jason "Jay"
Method for sensitizing solid tumors to immunotherapy
TS-065862 — The Need
In the landscape of cancer treatment, the emergence of immunotherapy has shown remarkable promise. However, its efficacy is not universal across all cancer types, and resistance development poses a significant challenge. Hyperprogression, characterized by accelerated tumor growth, further …
- College: College
of
Arts
&
Sciences
- Inventors: Kural, Comert; Djakbarova, Umidahan
- Licensing Officer: Wilburn, Adri
Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need:
In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
- College: College
of
Arts
&
Sciences
- Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
- Licensing Officer: Panic, Ana
Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year.
The Need
Developing drugs for cance…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
- Licensing Officer: Panic, Ana
Utilizing WT-IV-012 to improve immune checkpoint therapy in cancer treatment
TS-064262 — The Need
Addressing the limitations of current melanoma therapies, there exists a critical need for innovative approaches that enhance the effectiveness of immune checkpoint therapeutics. Despite advancements in immunotherapy, a significant percentage of melanoma patients do not achieve complete re…
- College: College
of
Arts
&
Sciences
- Inventors: Burd, Craig; Aguilar-Valenzuela, Renan; Burd, Christin
- Licensing Officer: Panic, Ana
Unveiling Biochemically Responsive MR Probes for Precision Beyond Limits
TS-064179 —
In the realm of medical diagnostics, the need for precise and non-invasive detection of molecular-level pathology has been a longstanding challenge. Traditional imaging techniques often fall short in providing detailed insights into biological processes at this scale. To address this gap, there is…
- College: College
of
Arts
&
Sciences
- Inventors: Shafaat, Hannah "Hannah"
- Licensing Officer: Dahlman, Jason "Jay"
A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
- College: College
of
Arts
&
Sciences
- Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
- Licensing Officer: Panic, Ana
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