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Strain‑Activated Programmable Surfaces for Controlled Drug Delivery in Mechanically Regulated Diseases
TS-072945 — Many mechanically mediated conditions such as vascular hypertension, glaucoma, and abdominal distension, present intermittent, unpredictable episodes that demand drug release only when symptoms emerge. Conventional platforms often leak at baseline, require external triggers, or cannot synchronize …
  • College: College of Engineering (COE)
  • Inventors: Zhao, Yi
  • Licensing Officer: Randhawa, Davinder

Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide. The Need Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
  • College: College of Engineering (COE)
  • Inventors: Purmessur Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Willson, Christopher

Localized Cylindrical Drug Delivery to Prevent Vascular Restenosis
TS-062216 — The Need: Addressing Vascular Restenosis with Extended Drug Delivery Vascular restenosis poses a significant medical challenge in the United States, particularly in cases of coronary artery disease treated with bypass grafting. The current methods involve using drug-loaded polymer formulations to d…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John
  • Licensing Officer: Dahlman, Jason "Jay"

Drug Delivery System for the Treatment of Neurological Diseases
TS-054464 — Novel drug delivery system that enables efficient transfer of FDA-approved drugs for the treatment of neurological injuries.
Traumatic brain and spinal cord injury cause devastating neurological deficits and long-term disability due to detrimental structural and functional alteration in neuronal circuits. Treatment of brain injury and neurological disorders has traditionally been challenging due to the inability to deli…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Fan, Fan; Tedeschi, Andrea
  • Licensing Officer: Willson, Christopher

Enhanced Extended-Release from Drug Delivering Capsules Containing Silicone Oils
TS-034543 — Implanted capsules containing silicone oil allow for continuous, low-level release of water-sensitive compounds such as contraceptives.
The Need: Effective long-term drug delivery remains a significant challenge due to the degradation of active agents over time, rendering traditional drug delivery vehicles ineffective. The need for a reliable drug delivery solution that maintains the biological activity of the drug over extended pe…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Coutinho da Silva, Marco
  • Licensing Officer: Dahlman, Jason "Jay"

Enhanced Extended-Release from Drug Delivering Capsules Containing Silicone Oils
TS-034461 — Implanted capsules containing silicone oil allow for continuous, low-level release of water-sensitive compounds such as contraceptives.
The Need: Effective long-term drug delivery remains a significant challenge due to the degradation of active agents over time, rendering traditional drug delivery vehicles ineffective. The need for a reliable drug delivery solution that maintains the biological activity of the drug over extended pe…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Coutinho da Silva, Marco
  • Licensing Officer: Dahlman, Jason "Jay"

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