Enhanced Extended-Release from Drug Delivering Capsules Containing Silicone Oils

Implanted capsules containing silicone oil allow for continuous, low-level release of water-sensitive compounds such as contraceptives.

The Need:

Effective long-term drug delivery remains a significant challenge due to the degradation of active agents over time, rendering traditional drug delivery vehicles ineffective. The need for a reliable drug delivery solution that maintains the biological activity of the drug over extended periods is evident. Addressing this critical commercial need would revolutionize the pharmaceutical industry by enabling the sustained and controlled release of hydrophilic active agents, ensuring optimal therapeutic outcomes for patients.

The Technology:

Our groundbreaking technology offers drug delivery compositions and devices that ensure the extended viability and controlled release of hydrophilic active agents. The core of our innovation lies in encapsulating the active agents within a polysiloxane polymer, which can consist of hydrophilic polysiloxane, amphiphilic polysiloxane, or a combination of both. Additionally, the technology allows for the incorporation of a hydrophobic polysiloxane polymer in some formulations to enhance performance.

Commercial Applications:

  • Long-term delivery of gonadotropin-releasing hormone (GnRH) agonists for contraceptive treatments.
  • Controlled release of hydrophilic pharmaceuticals for chronic diseases, such as diabetes or hormone-related conditions.
  • Sustained delivery of pain relief medications to manage chronic pain in patients.
  • Extended release of immunosuppressive drugs for organ transplant recipients.
  • Targeted drug delivery for the treatment of certain cancers or localized conditions.


  • Enhanced Drug Stability: The use of polysiloxane polymer ensures that hydrophilic active agents retain their biological activity over an extended period, preventing drug degradation and maximizing therapeutic efficacy.

  • Precise Delivery: The drug delivery capsules feature a well-designed wall with controlled pore sizes, enabling precise release kinetics and ensuring the right dosage reaches the target site.

  • Long-lasting Effect: The technology allows drug delivery capsules to release the active agent for at least 30 days to up to 12 months, providing prolonged treatment with fewer administrations.

  • Biodegradable Options: By incorporating biodegradable polymers into the capsule wall, the technology supports environmentally friendly drug delivery solutions that reduce waste and are easily absorbed by the body.

  • Versatile Manufacturing Process: The method of preparing drug delivery capsules through electrospinning offers scalability and flexibility, allowing efficient large-scale production with consistent quality.

In summary, our drug delivery compositions and devices represent a cutting-edge solution to the commercial challenge of maintaining active agent efficacy over extended periods. The technology's applications span a wide range of therapeutic areas, and the benefits it offers, such as enhanced drug stability, precise delivery, and biodegradable options, make it a game-changer in the pharmaceutical industry. Embrace this revolutionary technology and redefine the future of drug delivery.

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