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System and method for prediction of artificial intelligence model generalizability for unseen data
TS-075229 — Problem Artificial intelligence models often perform well during development but show unpredictable drops in accuracy and reliability when deployed on data that differ from their training sets. In high‑risk settings such as clinical care, these shifts can arise from changes in hardware, protocols…
  • College: College of Medicine (COM)
  • Inventors: Dikici, Engin; Nguyen, Xuan; Prevedello, Luciano
  • Licensing Officer: Hampton, Andrew

TL-iGeneCombo: Transfer Learning for Individual Sample Specific Gene Combination Effect Prediction and Selection in Cancer Cells
TS-075184 — Problem Synthetic lethality (SL) is defined as a gene combination effect (GCE) of two genes where loss-of-function of both genes, rather than one, causes cell death. While carrying strong therapeutic potential in the treatment of cancer, SL interactions are context specific and sparse, thereby limi…
  • College: College of Medicine (COM)
  • Inventors: Li, Lang; Gökbağ, Birkan
  • Licensing Officer: Hampton, Andrew

EmitGCL: Prediction of Future Metastasis based on Graph Contrastive Learning
TS-075168 — Problem Metastasis is the primary driver of cancer-related deaths, yet accurately predicting its onset is a major clinical challenge. Current diagnostic tools often fail to detect occult metastatic cells and metastatic precursor cells, resulting in either overdiagnosis, with unnecessary treatments,…
  • College: College of Medicine (COM)
  • Inventors: Ma, Qin; Wang, Xiaoying
  • Licensing Officer: Hampton, Andrew

Hybrid Collaborative Filtering Methods for Recommending Search Terms to Clinicians
TS-063237 — Electronic Health Records (EHR) are used in over 88% of all US medical clinics to improve care and streamline data. In addition, they enable sharing of data to multiple providers dealing with the same patient, thereby enhancing efficiency and care. The Need In the last decade, medical practices…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Peng, Bo; Ren, Zhiyun
  • Licensing Officer: Hampton, Andrew

Patient Access Prioritization Score
TS-063212 — When a patient demonstrates signs of imminent clinical deterioration, it is essential to immediately assess and treat the patient to prevent intensive care unit transfer, cardiac arrest, or death. These tasks often include transferring the patient to other facilities with optimal capabilities. T…
  • College: College of Medicine (COM)
  • Inventors: Reinbolt, Raquel; Cohn, David
  • Licensing Officer: Hampton, Andrew

Force Plate Surface Calibration Device
TS-063194 — The Need In the medical and healthcare arena, force plate technology is frequently relied upon for evaluating a patient’s ability to meet normal human standards when performing different physical activities and determining the presence of limitations in mechanistic-type behaviors due to age, …
  • College: College of Medicine (COM)
  • Inventors: Onate, James; Caccese, Jaclyn; Edwards, Nathan; Hagen, Joshua; Kang, Yun Seok
  • Licensing Officer: Hampton, Andrew

Method for Prediction of Artificial Intelligence Model Generalizability for Unseen Data
TS-063039 — Medical-based AI systems have seen increased use in recent years across a range of applications (e.g., diagnostics, prognostics, treatment response prediction). Their widespread adoption by the medical community is still restricted, primarily due to their limited ability to realize a high degree of
  • College: College of Medicine (COM)
  • Inventors: Dikici, Engin; Nguyen, Xuan; Prevedello, Luciano
  • Licensing Officer: Hampton, Andrew

Transforming PAH Management with PHORA: Empowering Physicians for Better Patient Care
TS-062764 — The Pulmonary Hypertension Outcomes Risk Assessment (PHORA): a PAH risk stratification tool.
Pulmonary Arterial Hypertension (PAH) demands precise risk stratification for effective patient management. Clinical decision support tools can help inform treatment decisions made by physicians and other healthcare providers, usually at the point of care. The Need Current methods for assistin…
  • College: College of Medicine (COM)
  • Inventors: Benza, Ray; Lin, Shili; Mathur, Puneet
  • Licensing Officer: Hampton, Andrew

AI-Enabled Retrosynthesis for Drug Development
TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.
A time-consuming and costly step in drug development is the identification of drug-like small molecules that display desired properties against a specific biomolecular target and then the synthesis of such molecules if they do not exist. Retrosynthesis is a procedure where such a desired molecule i…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Chen, Ziqi
  • Licensing Officer: Hampton, Andrew

SimPi: A Remote Power Platform for Simulation
TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.
Simulations are essential for evaluating the potential impacts of disasters and for creating effective preparedness and response plans to facilitate organized and coordinated actions. Since response plans are not theoretical exercises, they must frequently be tested to be evaluated, adapted, and u…
  • College: College of Medicine (COM)
  • Inventors: Winfield, Scott; Beck, James; Finnegan, Geoff
  • Licensing Officer: Hampton, Andrew

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