IR Precision: Revolutionizing Colorectal Cancer Metastasis Diagnosis with the CCML Library
TS-064834 — The Need: Colorectal cancer remains a significant global health challenge, particularly when it metastasizes to the liver. Accurate and rapid diagnosis of metastatic liver lesions is crucial for effective treatment planning and patient outcomes. Traditional diagnostic methods often lack the specific…
- College: College
of
Arts
&
Sciences
- Inventors: Coe, James; Allen, Heather; Bradley, Rebecca; Hitchcock, Charles; Martin, Edward
- Licensing Officer: Willson, Christopher
Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year.
The Need
Developing drugs for cance…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
- Licensing Officer: Willson, Christopher
Unveiling Biochemically Responsive MR Probes for Precision Beyond Limits
TS-064179 —
In the realm of medical diagnostics, the need for precise and non-invasive detection of molecular-level pathology has been a longstanding challenge. Traditional imaging techniques often fall short in providing detailed insights into biological processes at this scale. To address this gap, there is…
- College: College
of
Arts
&
Sciences
- Inventors: Shafaat, Hannah "Hannah"
- Licensing Officer: Dahlman, Jason "Jay"
A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
- College: College
of
Arts
&
Sciences
- Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
- Licensing Officer: Willson, Christopher
Network-based Approach for Accurate Brain Modeling
TS-062628 — More than a billion people worldwide suffer from some neurological disorders, such as Alzheimer's, Parkinson's, multiple sclerosis, epilepsy, stroke, autism, addiction, and many others. These conditions result in more than 7 million deaths, with associated costs exceeding $1.5 trillion annua…
- College: College
of
Arts
&
Sciences
- Inventors: Cranmer, Skyler; Bhamidi, Shankar; Denny, Mathew; Desmarais, Bruce; Lu, Zhong-Lin; Stillman, Paul; Wilson, James
- Licensing Officer: Dahlman, Jason "Jay"
Methods and Apparatus to Improve MRI Efficiency
TS-062627 — Magnetic Resonance Imaging (“MRI”) is one of the most important modern medical imaging modalities. It has far less risk of side effects than most other imaging modalities. Generally, a high quality image requires high signal-to-noise ratio, high contrast between normal and pathological t…
- College: College
of
Arts
&
Sciences
- Inventors: Wang, Jinghua
- Licensing Officer: Panic, Ana
Tunable Fingerloop DNA antisense motifs for nucleic acid targeting and detection technologies
TS-062555 — The Need: Improved Nucleic Acid Detection Probes
There is a growing need for advanced detection probes that can effectively identify target nucleic acid sequences while reducing binding to mismatched targets. Existing technologies often suffer from false positive results due to temperature fluctuat…
- College: College
of
Arts
&
Sciences
- Inventors: Lease, Richard
- Licensing Officer: Dahlman, Jason "Jay"
Sensor for detecting Viruses
TS-062553 — The Need
The swift and accurate diagnosis of COVID-19 and other viruses is crucial in preventing their spread. Current detection methods like PCR and antibody testing have limitations, including long run times, sample preparation, and high false negative rates. Moreover, with the rapid mutation and…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Payne, Taylor
- Licensing Officer: Willson, Christopher
Functional "fingerloop" DNA antisense motifs for nucleic acid targeting and detection technologies
TS-062547 — The Need: The field of molecular biology and genetic engineering faces challenges in achieving precise and accurate detection and amplification of target nucleic acid sequences. Traditional hybridization technologies suffer from the issue of mismatched targets, leading to reduced specificity and rel…
- College: College
of
Arts
&
Sciences
- Inventors: Lease, Richard
- Licensing Officer: Dahlman, Jason "Jay"
Visual Function Mapping Technology: Enhancing Vision Care and Diagnostics
TS-062335 — The Need: In the field of ophthalmology and vision care, there is a critical need for accurate and comprehensive measurements of visual function over the entire visual field. Conditions such as glaucoma, age-related macular degeneration (AMD), diabetes, stroke, pituitary disease, brain tumors, and n…
- College: College
of
Arts
&
Sciences
- Inventors: Lu, Zhong-Lin; Lesmes, Luis; Xu, Pengjing "PJ"; Yu, Deyue
- Licensing Officer: Dahlman, Jason "Jay"
Rapid Identification of Eye Disorders
TS-062311 — The Need: Early detection of eye disorders, such as amblyopia and myopia, is crucial for effective treatment and improved long-term outcomes, especially in children and young adults. Traditional screening methods for amblyopia often require specialized instruments and expertise, making them costly, …
- College: College
of
Arts
&
Sciences
- Inventors: Lu, Zhong-Lin; Huang, Chang-Bing; Jia, Wuli; Lesmes, Luis; Zhou, Jiawei
- Licensing Officer: Dahlman, Jason "Jay"
Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
- College: College
of
Arts
&
Sciences
- Inventors: Badu-Tawiah, Abraham; Damon, Deidre
- Licensing Officer: Dahlman, Jason "Jay"
Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed
of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
- College: College
of
Arts
&
Sciences
- Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
- Licensing Officer: Dahlman, Jason "Jay"
Design and apparatus for efficient measurement of the time course of perceptual sensitivity change
TS-037470 — A novel method
of measuring the time course
of degradation
of perceptual sensitivity due to disease
Perception is the biological process that allows humans to differentiate external stimuli such as shapes and colors. Certain diseases affect perceptual sensitivity, usually resulting in a slow but measurable degrade in skill that correlates with the progression of the disease. Existing methods to …
- College: College
of
Arts
&
Sciences
- Inventors: Lu, Zhong-Lin; Lesmes, Luis; Zhao, Yukai
- Licensing Officer: Dahlman, Jason "Jay"