TS-065460 — The Need Cancer remains one of the most pressing medical challenges worldwide, necessitating novel therapeutic approaches to combat its proliferation. Despite advancements, targeted therapies are often limited by immune responses or cumbersome production processes. There's a growing demand for …

TS-065459 — The Need The emergence of HIV-1 infection continues to pose significant challenges in healthcare worldwide. Current treatment approaches primarily target viral components, leading to the development of drug resistance over time. There is a pressing need for innovative therapeutic strategies that di…

TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…

TS-064581 — Antibodies are essential therapeutic modalities for treating a plethora of different diseases, ranging from cancer, autoimmune disorders, degenerative diseases, and inflammation. The FDA approved the first antibody over three decades ago, and since more than 570 have been studied in clinical trials,…

TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…

TS-064262 — The Need Addressing the limitations of current melanoma therapies, there exists a critical need for innovative approaches that enhance the effectiveness of immune checkpoint therapeutics. Despite advancements in immunotherapy, a significant percentage of melanoma patients do not achieve complete re…

TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…

TS-062627 — Magnetic Resonance Imaging (“MRI”) is one of the most important modern medical imaging modalities. It has far less risk of side effects than most other imaging modalities. Generally, a high quality image requires high signal-to-noise ratio, high contrast between normal and pathological t…

TS-062556 — The Need: Noninvasive Biodosimetry Technology for Radiation Exposure Detection Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require …

TS-062553 — The Need The swift and accurate diagnosis of COVID-19 and other viruses is crucial in preventing their spread. Current detection methods like PCR and antibody testing have limitations, including long run times, sample preparation, and high false negative rates. Moreover, with the rapid mutation and…

TS-062439 — The Need: Addressing the Growing Threat of Gram-Negative Bacterial Infections Gram-negative bacterial pathogens, including Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, are responsible for more than 35% of common hospital-acquired infections. These no…

TS-062336 — The Need: Enhancing Collaborative Interaction for Children with Disabilities Millions of children in the United States with physical or cognitive disabilities face challenges in participating fully in play and forming meaningful connections with their parents and caregivers. The lack of touch and c…

TS-062335 — The Need: In the field of ophthalmology and vision care, there is a critical need for accurate and comprehensive measurements of visual function over the entire visual field. Conditions such as glaucoma, age-related macular degeneration (AMD), diabetes, stroke, pituitary disease, brain tumors, and n…

TS-062320 — The Need: Addressing Susceptibility to Cutaneous Leishmaniasis Cutaneous leishmaniasis, caused by the intracellular parasite Leishmania major and transmitted by sand flies, poses a significant threat to susceptible populations. This disfiguring disease results in large skin lesions, impacting both …

TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.

TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…

TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.

TS-038221 — A knock-in murine model that expresses high levels of GFP in CXCR3 positive cells.

TS-037948 — A device and software package that can help people with amblyopia, and other visual impairment problems, at a higher efficiency

TS-036760 — Immunomodulating agents have been engineered from Notch receptor ligand extracelluar domains. These are useful for stimulating the immune system.