Protease-free Bacillus subtilis host
TS-065845 — The Need: In the realm of biotechnology, the challenge of synthesizing enzymes, pharmaceuticals, and fine chemicals efficiently is paramount. However, the presence of multiple proteases secreted by Bacillus subtilis 168 during growth stages poses a significant obstacle to achieving optimal productio…
- College: College
of
Arts
&
Sciences
- Inventors: Zeigler, Daniel
- Licensing Officer: Willson, Christopher
SUMO^RIT Tag: Revolutionizing Downstream Gene Translation
TS-065844 — The Need: In modern biotechnology and pharmaceutical industries, precise control over gene expression is paramount. However, conventional translation processes often lead to inefficiencies, resulting in reduced yields and compromised protein function. Meeting the demand for enhanced gene expression …
- College: College
of
Arts
&
Sciences
- Inventors: Law, Jamison
- Licensing Officer: Willson, Christopher
Antibiotic-free selection of plasmids for recombinant DNA technology applications
TS-065461 — The Need: In the field of modern biochemistry, the production of recombinant proteins in bacterial hosts like Escherichia coli is integral for both research and industrial applications. However, the traditional method of using antibiotics for selection in protein production is costly and contributes…
- College: College
of
Arts
&
Sciences
- Inventors: Gopalan, Venkat
- Licensing Officer: Willson, Christopher
Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need:
In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
- College: College
of
Arts
&
Sciences
- Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
- Licensing Officer: Willson, Christopher
Revolutionizing RNA-Protein Interaction Mapping: Precision Proximity Labeling Technology
TS-065456 — The Need
In modern biological research, there is a pressing demand for technologies that enable precise mapping of RNA-protein interactions within Ribonucleoprotein (RNP) complexes. Traditional methods often lack the capability to pinpoint these interactions at the level of secondary structure moti…
- College: College
of
Arts
&
Sciences
- Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"
- Licensing Officer: Willson, Christopher
Advancing RNA Detection with Innovative Peptide-Based Fluorescent Probes
TS-065455 — The Need: In modern biotechnology and biomedical research, there is an escalating demand for efficient tools that can accurately detect and analyze specific RNA sequences. The ability to precisely target and identify RNA molecules, particularly U-rich sequences, is crucial for various applications s…
- College: College
of
Arts
&
Sciences
- Inventors: Bong, Dennis; DeSantis, Christopher; Gopalan, Venkat; Liang, Yufeng; Mao, Jie; Marathe, Ila; Miao, Shiqin "Shiqin"
- Licensing Officer: Willson, Christopher
Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need
In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
- College: College
of
Arts
&
Sciences
- Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
- Licensing Officer: Panic, Ana
COLMARppm: web-server tool for prediction of NMR chemical shifts
TS-064585 — COLMARppm offers a swift and accurate solution to the longstanding challenges in metabolomics research. Unique features and capabilities position it as a crucial tool for researchers seeking to unlock unknown metabolites, contributing to health research
The Need
In the field of metabolomics resear…
- College: College
of
Arts
&
Sciences
- Inventors: Bruschweiler, Rafael; Li, Dawei "Dawei"; Rigel, Nick
- Licensing Officer: Dahlman, Jason "Jay"
Magnetic Nanoparticles for Cancer Cell Classification
TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year.
The Need
Developing drugs for cance…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Rist, David; Skardal, Aleksander; Venere, Monica
- Licensing Officer: Willson, Christopher
Co-Axial Contained Electrospray Ionization Platform for Mass Spec.
TS-064299 — Mass spectrometry (MS) is used across a wide range of applications involving analytical chemistry. Various MS techniques, often coupled with liquid chromatography (LC), allow for detection of various chemical analytes, from drug metabolites, pesticides, food adulterants, and natural product extracts…
- College: College
of
Arts
&
Sciences
- Inventors: Badu-Tawiah, Abraham; Burris, Benjamin "Ben"; Grooms, Alex; Heiss, Derik; Kulyk, Dmytro
- Licensing Officer: Dahlman, Jason "Jay"
Drosophila melanogaster muscle stem cell line
TS-064271 — The Need
In the rapidly advancing landscape of life sciences, researchers and biotech companies face an escalating demand for reliable and versatile cell lines. The need for a specialized cell line that combines adaptability, reproducibility, and ease of use is paramount in accelerating breakthroug…
- College: College
of
Arts
&
Sciences
- Inventors: Simcox, Amanda
- Licensing Officer: Dahlman, Jason "Jay"
Column-free Purification of Recombinant Proteins
TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …
- College: College
of
Arts
&
Sciences
- Inventors: Gopalan, Venkat
- Licensing Officer: Panic, Ana
Advanced AAV Gene Therapy Characterization Technique
TS-062608 — Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight infection. These next-generation treatments hold promise for treating various genetic and chronic conditions, including but not limited to cancer, cystic …
- College: College
of
Arts
&
Sciences
- Inventors: Wysocki, Vicki; Cleary, Sean; Du, Chen
- Licensing Officer: Dahlman, Jason "Jay"
Air-Tight Ambient Mass Spectrometry
TS-062559 — The Need: In the rapidly expanding field of Li-ion battery technology, understanding the composition and behavior of the solid electrolyte interface (SEI) is crucial for enhancing battery performance and safety. However, the SEI components, specifically lithium ethylene mono carbamate and lithium et…
- College: College
of
Arts
&
Sciences
- Inventors: Badu-Tawiah, Abraham; Hadad, Christopher; Lalisse, Remy; Sahraeian, Taghi; Wu, Yiying; Zheng, Jingfeng
- Licensing Officer: Dahlman, Jason "Jay"
Fluorescent probes for intracellular RNA tracking
TS-062554 — The Need: Intracellular RNA fluorescence labeling is a crucial technique for studying cellular processes and understanding gene expression. However, the conventional MS2 labeling method using protein fusion labels can have drawbacks, such as increased mass, potential steric accessibility issues, and…
- College: College
of
Arts
&
Sciences
- Inventors: Bong, Dennis; Liang, Yufeng
- Licensing Officer: Willson, Christopher
Functional "fingerloop" DNA antisense motifs for nucleic acid targeting and detection technologies
TS-062547 — The Need: The field of molecular biology and genetic engineering faces challenges in achieving precise and accurate detection and amplification of target nucleic acid sequences. Traditional hybridization technologies suffer from the issue of mismatched targets, leading to reduced specificity and rel…
- College: College
of
Arts
&
Sciences
- Inventors: Lease, Richard
- Licensing Officer: Dahlman, Jason "Jay"
Bat Tissue Samples (Desmodus rotundus)
TS-062351 — The Need: In today's fast-paced world, advancements in scientific research and medical breakthroughs are critical to addressing pressing global challenges. The study of bats and their unique biology has become increasingly important due to their potential role as reservoirs for zoonotic diseases…
- College: College
of
Arts
&
Sciences
- Inventors: Carter, Gerald
- Licensing Officer: Dahlman, Jason "Jay"
Method and device for determining virus titer by surface enhanced Raman scattering
TS-062346 —
The ability to rapidly identify and determine virus titer is of utmost importance in numerous biomedical applications, ranging from gene editing to pharmaceutical and vaccine development. In the context of lentiviruses, which are widely used for cell reprogramming in immunotherapies, knowing the e…
- College: College
of
Arts
&
Sciences
- Inventors: Schultz, Zachary; Morder, Courtney
- Licensing Officer: Willson, Christopher
Ion Carpet-Based Surface-Induced Dissociation Device
TS-062342 — The Need
In the field of mass spectrometry (MS), the study of proteins and protein complexes in their native form, known as native MS, has become crucial in understanding their structure and function. However, the current collision-induced dissociation (CID) technique used in tandem MS experiments …
- College: College
of
Arts
&
Sciences
- Inventors: Wysocki, Vicki; Gilbert, Joshua; Stiving, Alyssa
- Licensing Officer: Dahlman, Jason "Jay"
Show More Technologies