Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosisSmall molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance. The Need: Combating Avian Pathogenic E. coli (APEC) Infections in Poultry Avian Pathogenic E. coli (APEC) poses a significant threat to the poultry industry worldwide, causing severe economic losses due to increased mortality and decreased growth rate of infected birds. Additionally, APEC is suspected to be a potential source of antimicrobial resistance, which further complicates its treatment. To address this urgent need for effective control and prevention of APEC infections, we present groundbreaking anti-APEC agents as powerful therapeutics for managing APEC outbreaks in poultry. The Technology: Advanced Anti-APEC Agents The technology consists of innovative anti-APEC agents that offer two distinct mechanisms to combat APEC infections in poultry. These agents have been specifically designed to target APEC strains effectively, including antimicrobial-resistant variants, while providing added advantages in combination with other antibiotics. The technology encompasses two types of anti-APEC agents: growth inhibitors that target the APEC cell membrane and quorum sensing inhibitors (QSIs) that reduce the bacterial virulence of APEC. Commercial Applications:
Benefits/Advantages:
In summary, our advanced anti-APEC agents offer an effective, versatile, and innovative solution to combat APEC infections in poultry, thereby addressing a critical commercial need in the poultry industry while potentially contributing to the reduction of antimicrobial resistance. Implementing these agents in flock management protocols and treatment strategies can lead to improved bird health, increased productivity, and greater economic gains for poultry producers worldwide.
Patents
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Tech IDT2018-175 CollegeCollege of Food, Agricultural, and Environmental Sciences (CFAES) Licensing ManagerDahlman, Jason "Jay" InventorsCategories |