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Rabbit Model for Duchenne Muscular Dystrophy
TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.
There has yet to be a DMD animal model that bridges the gap between cost effectiveness and scientific relevance. This new rabbit model does that. DMD is a lethal genetic disease characterized by progressive muscle weakness and muscle wasting. There are several animal models for DMD, includin…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi
  • Licensing Officer: Davis, Stewart

Anti-GARP Monoclonal Antibodies for Cancer Therapy
TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.
Although immune checkpoint blockade (ICB) has emerged as a promising cancer immunotherapy, a majority of tumors fail to respond to ICB. A potential mechanism driving this failed response is the accumulation of TGF-β1 in the tumor microenvironment (TME), which drives immune dysfunction by indu…
  • College: College of Medicine (COM)
  • Inventors: Li, Zihai
  • Licensing Officer: He, Panqing

An Orally Active, Selective Inhibitor of CD4+ T-Cell Activation That Blunts Left-Ventricular Remodeling and Improves Cardiac Function during Chronic Heart Failure
TS-057777 — A novel orally-active drug molecule that can inhibit pathological CD4+ T-cells at clinically translatable doses and, blunts progressive cardiac dysfunction and left-ventricular (LV) remodeling during Heart Failure (HF).
HF afflicts ~6.5 million adults in US with 50% mortality in first 5 years. It has an estimated market size of $4.2B USD in US alone with a forecasted CAGR of 23% from 2018-2028. Current HF treatments are mostly aimed at alleviating symptoms rather than treatment, resulting in progressive cardiac d…
  • College: College of Medicine (COM)
  • Inventors: Bansal, Shyam; Gumina, Richard
  • Licensing Officer: He, Panqing

Albumin-SN-38 Conjugate (AlbuCure) for Cancer Therapy
TS-057776 — A novel protein-drug conjugate of human serum albumin chemically conjugated to SN-38, solubilizing the potent chemotherapeutic. This therapy has the potential to treat many tumors with poor prognosis, including pancreatic, lung, breast, colorectal, ovarian, sarcoma, head and neck cancer, urothelial malignancies, and others.
Many solid tumors have poor prognosis despite recent progress in molecularly targeted therapy and immunotherapy. Irinotecan/CPT-11, a chemotherapy on the WHO Essential Medicines List, is approved for use in colorectal cancer, lung cancer, pancreatic cancer, gastric cancer, malignant glioma, and sa…
  • College: College of Medicine (COM)
  • Inventors: Williams, Terence; Lee, Robert
  • Licensing Officer: He, Panqing

High Efficiency LED Designs Using Quantum Well Engineering
TS-057127 — Achieving high efficiency LEDs with green, amber and longer wavelengths using III-nitride/II-IV-nitride heterostructures as the active media.
Although extensive research and development over the past two decades has resulted in close to 100% external quantum efficiency (EQE) of InGaN based blue light emitting devices, efficiency of the longer visible wavelength emitting devices has remained relatively low. Spontaneous polarization origi…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Zhang, Kaitian
  • Licensing Officer: Ashouripashaki, Mandana

Blending Proteins for Improved Functionality
TS-056508 — Although demand for natural, high-quality, and preservative-free protein beverages is growing, current methods for producing these products are limited. Therefore, new approaches that generate highly tunable and natural products are needed to support health-promoting lifestyles.
The Need Consumers have substantial demand for customizable liquid foods, beverages, and dietary solutions that will help them more aggressively meet their unique nutrition and personal health goals. While there are many methods for producing various formulations, there is high interest in liquid f…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Balasubramaniam, V M "Bala"; Janahar, Jerish; Jimenez-Flores, Rafael
  • Licensing Officer: Dahlman, Jason "Jay"

A novel mouse model of spontaneous chronic lymphocytic leukemia
TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.
The Need Chronic lymphocytic leukemia (CLL) accounts for one quarter of new cases of leukemia. CLL is the most prevalent adult leukemia in Western countries and is characterized by a mature B-cell phenotype. Given the burden of this disease, a large pipeline of drugs for treatment are in progress…
  • College: College of Medicine (COM)
  • Inventors: Lapalombella, Rosa; Blachly, James; Byrd, John
  • Licensing Officer: Davis, Stewart

Micro-Resonator Design Implementing Internal Resonance for micro electro-mechanical systems (MEMS) Applications
TS-054917 — This invention ensures the consistent frequency of micro electro-mechanical system resonator-based oscillators by using a novel thin-layer stepped beam.
Computer processors are used every minute of every day in phones, cars, computers, TVs, and as the “Internet of Things” expands to refrigerators, toasters, and more processers define how we live our lives. These processors rely on mechanical oscillators and resonators that work togethe…
  • College: College of Engineering (COE)
  • Inventors: Cho, Han Na "Hanna"; Yu, Jun
  • Licensing Officer: Zinn, Ryan

Reservoir Simulations Tools to Inform Natural Hydrogen Exploration and Production Strategies
TS-054822 — Naturally occurring hydrogen is found in subsurface formations. Successful exploration for subsurface resources requires a systematic understanding of the occurrence and evolution of the resource within various geologic environments. Evolution of the modeling capabilities of previously developed p…
  • College: College of Arts & Sciences
  • Inventors: Moortgat, Joachim; Darrah, Thomas
  • Licensing Officer: Ashouripashaki, Mandana

Machine Learning Techniques for the Identification of Geomorphological Features to Identify Subsurface Natural Hydrogen Reservoirs
TS-054820 — Naturally occurring hydrogen is found in subsurface formations. Successful exploration for subsurface resources requires a systematic understanding of the occurrence and evolution of the resource within various geologic environments. Remote sensing (acquiring, processing, and interpreting images a…
  • College: College of Arts & Sciences
  • Inventors: Darrah, Thomas; Howat, Ian; Moortgat, Joachim; Whyte, Colin
  • Licensing Officer: Ashouripashaki, Mandana

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