TS-075868 — Clinicians managing pediatric patients supported by a ventricular assist device must routinely assess pump performance by visually estimating membrane fill and ejection during pump cycles. These evaluations are critical for patient management but are inherently subjective, time-consuming, and pron…

TS-075261 — Problem Hemolysis, the process by which the red blood cell membrane ruptures, releasing hemoglobin (Hb), is typically managed in mammalian organisms by intrinsic proteins such as hemopexin (Hpx) and haptoglobin (Hp). However, their concentrations in plasma are very limited, so, in conditions with s…

TS-075238 — Problem Low titer group O whole blood (LTOWB) is the gold standard used by the US military to treat blood loss. However, there is a limited supply with ex vivo storage and shelf-life limitations. There is no whole blood substitute on the market when LTOWB is not available. Solution Dr. Andre Palmer and team have developed several whole blood substitute formulations to mimic the 3 main functions of whole blood: 1) oxygen transport (provided by hemoglobin-based oxygen carrier [HBOC]); 2) clotting (provided by tranexamic acid); and 3) volume replacement (provided by a plasma substitute). The HBOC consists of T-state polymerized human hemoglobin (PolyhHb). The clotting agent consists of tranexamic acid (TXA). The volume replacement solution consists of polymerized human serum albumin (PolyHSA). Additional additives include high molecular weight polyethylene glycol as a drag reducing agent, and dexamethasone as an anti-inflammatory agent. Applications Prehospital and austere environments Used by EMS and military for early resuscitation before hospital arrival Hospital trauma protocols Used for first-line transfusion in exsanguinating patients Advantages Mimics the three major functions of whole blood without the risk of blood type incompatibility and disease transmission Extended shelf life versus whole blood Scalable production Seeking opportunities for out-licensing and collaboration

TS-075185 — Problem The lipolysis-stimulated lipoprotein receptor (LSR) is a promising target for cancer therapy. LSR is overexpressed in many tumor tissues with metastatic signatures such as breast, gastric, and endometrial cancer. LSR expression levels may serve as prognostic indicators and help stratify pat…

TS-075179 — Problem Mitochondria is a promising target for cancer treatment. However, current strategies to specifically and effectively destroy cancer mitochondria in vivo are limited. Solution Applications Competitive Advantages Seeking Opportunities for Licensing and collaboration

TS-075177 — Problem Glioblastoma multiforme (GBM) is the most malignant form of gliomas and the most lethal primary brain tumors in adults. Current biomarkers or clinical features from tissue biopsy samples cannot distinguish glioma true progression from pseudoprogression and might not be suited to monitoring …

TS-075165 — Problem Neuroendocrine tumors (NETs) are often metastatic at diagnosis, thus limiting surgical options. Chemotherapies offer limited efficacy and high toxicity. Meningiomas, though usually benign, are the most common intracranial tumors. Both NETs and meningiomas overexpress SSTR2, making it a prom…

TS-074779 — Myopia is rapidly increasing worldwide and is now recognized as a leading cause of irreversible vision impairment due to associated complications such as retinal degeneration, glaucoma, and structural eye changes. Despite this growing burden, clinicians lack practical tools to assess structural ch…

TS-074767 — Chronic and complex wounds remain a major clinical and economic burden, with high infection rates, slow healing trajectories, and limited real-time monitoring capabilities. Conventional dressings are largely passive and do not adapt to dynamic wound environments, while existing advanced therapies …

TS-074669 — Current cardiac MRI workflows rely heavily on breath-holds, ECG gating, and retrospective binning, which break down in patients with arrhythmias, irregular breathing, or limited ability to cooperate. Existing 3D approaches often average away beat-to-beat variability or suffer from motion artifacts…

TS-074278 — Millions of individuals with mobility impairments lack practical, scalable assistance for gait rehabilitation and daily ambulation. Existing powered exoskeletons are often heavy, expensive, complex to don, and poorly suited for long-duration or everyday use. Passive walkers and orthotic devices pr…

TS-073320 — Current methods for engineering micro- and nanoscale surface topographies on elastomeric materials are often costly, complex, and incompatible with scalable manufacturing. Yet, surface microstructures are critical for enhancing biological interactions in wound healing materials, such as promoting …

TS-073028 — Neonatal units need unobtrusive, continuous monitoring of presence, posture, motion, and growth metrics (recumbent length, optional weight) without cameras, wires, or labor‑intensive workflows. Frequent, accurate measurements are critical for early detection of growth deviations and unsafe sleep…

TS-072945 — Many mechanically mediated conditions such as vascular hypertension, glaucoma, and abdominal distension, present intermittent, unpredictable episodes that demand drug release only when symptoms emerge. Conventional platforms often leak at baseline, require external triggers, or cannot synchronize …

TS-072319 — The Need Current methods for mapping electrical potential gradients in biological tissues, such as the brain, rely on high-density electrode arrays fabricated via costly microfabrication techniques. These rigid devices struggle to conform to complex tissue morphologies, limiting their effectiveness …

TS-072052 — The Need Current wearable sensors for muscle health are limited in their ability to track real-time geometric changes in muscle size and shape, especially outside controlled laboratory environments. Existing solutions, such as force myography and ultrasound, either lack direct geometric insight or a…

TS-071847 — The Need Current fast neutron detection technologies suffer from inherently low sensitivity due to the limited interaction cross-section between neutrons and atomic nuclei. This restricts their effectiveness in critical applications such as nuclear security, radiation dosimetry, and advanced imaging…

TS-071745 — The Need Current two-way shape memory polymers (SMPs) require expensive, crystalline or liquid crystalline monomers and complex synthesis, limiting their use in cost-sensitive and biocompatible applications. Widely used amorphous polymers (e.g., polystyrene, PMMA) are inexpensive and common in con…

TS-071414 — The Need Current neurochemical monitoring technologies are limited by bulky form factors, complex fabrication, and invasiveness, which restrict their clinical and research utility. Existing sensors often cause tissue damage, lack real-time resolution, and are costly to manufacture, impeding widespre…

TS-070304 — The Need Current clinical methods for assessing tremor severity in patients with Parkinson’s disease and other movement disorders rely heavily on subjective, qualitative observations, such as evaluating hand-drawn spirals or observing motor tasks. These approaches lack precision, are difficult…

TS-069527 — The Need Cardiovascular MRI (CMR) data acquisition is often time-consuming and relies on complex reconstruction methods that do not fully exploit the spatial and temporal structure of CMR data. There is a need for a more efficient, unsupervised approach that can accelerate CMR imaging while maintai…

TS-067943 — Monitoring human physiological functions and performance during real-time activities is becoming increasingly popular in sporting and healthcare environments. Many studies now suggest that the quantitative evaluation of kinetic parameters, joint range of motion, heart rate, and breathing rate can be…

TS-067810 — Work environments and other brain-intensive activities impose high demands on the cognitive and cerebral resources required to process vast amounts of information. This high demand can expose individuals to cognitive overload, which can be dangerous for their health and lead to errors and accidents.…

TS-067796 — A handheld device for identifying preterm blood vessels in neonatal ICU.

TS-067550 — A method to improve the performance and accuracy of ML-based decision trees.

TS-067045 — The Need Wireless implants with integrated antennas are highly desirable for diagnostic, therapeutic, and monitoring applications due to their ability to communicate directly with external devices. However, the need for major surgical incisions to implant these devices poses significant risks, incl…

TS-066962 — The Need Viral disease surveillance (e.g. influenza, SARS-CoV-2) in high-risk settings faces several challenges, such as asymptomatic carriers, incomplete reporting, resource limitations, and delayed diagnosis of traditional swab test methods. These challenges could allow a virus to silently spread…

TS-066957 — The Need Colorimetric tests and remote image analysis are used in a wide range of industrial and medical applications. Digital image-based measurements made with smartphones are a promising platform to quantify colors at low cost, but suffer from inconsistency and errors caused by lens quality, sen…

TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment

TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications

TS-065892 — The Need The microscopic worm C. elegans is a model animal studied in more than 1500 biological and medical research laboratories worldwide due to its genetic manipulability and optical transparency. In C. elegans research, the manual process of picking worms between plates presents a significant …

TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders

TS-065424 — Due to environmental concerns and the decreasing supply of fossil fuels, there is substantial demand for nuclear-based energy production. Nuclear energy now provides about 10% of the world's electricity from about 440 power reactors and is the second largest source of low-carbon power. In addition, over 50 smaller countries utilize nuclear energy in about 220 research-size reactors. These reactors are used to produce medical and industrial isotopes and several other purposes.

TS-064181 — In the rapidly evolving landscape of nanotechnology, there exists a critical demand for scalable and efficient methods of producing nanoparticles. Current approaches, often confined to small-scale batches, hinder the widespread implementation of nanomaterials in diverse fields such as medicine, bi…

TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.

TS-063959 — The Need Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …

TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.

TS-063471 — In an increasingly digital world, the demand for efficient and reliable photodetectors is paramount. These devices are critical for a variety of applications, from medical imaging to defense systems. However, traditional photodetectors often struggle with low UV-visible rejection, limiting their e…

TS-063433 — A new pharmacologic modality for treating AFib.

TS-063238 — A novel regularization technique applicable for medical imaging applications that leverages conditional generative adversarial networks (cGANs) to generate reconstructed images in significantly shorter timeframes. The Need Several techniques are used for image reconstruction in the medical aren…