TS-065892 — The Need The microscopic worm C. elegans is a model animal studied in more than 1500 biological and medical research laboratories worldwide due to its genetic manipulability and optical transparency. In C. elegans research, the manual process of picking worms between plates presents a significant …

TS-065424 — Due to environmental concerns and the decreasing supply of fossil fuels, there is substantial demand for nuclear-based energy production. Nuclear energy now provides about 10% of the world's electricity from about 440 power reactors and is the second largest source of low-carbon power. In addition, over 50 smaller countries utilize nuclear energy in about 220 research-size reactors. These reactors are used to produce medical and industrial isotopes and several other purposes.

TS-064181 — In the rapidly evolving landscape of nanotechnology, there exists a critical demand for scalable and efficient methods of producing nanoparticles. Current approaches, often confined to small-scale batches, hinder the widespread implementation of nanomaterials in diverse fields such as medicine, bi…

TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.

TS-063963 — The Need In the dynamic realm of space exploration, the imperative to sustain life during extended missions places a critical demand on understanding the impact of spaceflight on plant growth. Traditional DNA sequencing methods employed by NASA fall short when dealing with plant material, necessita…

TS-063959 — The Need Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …

TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.

TS-063471 — In an increasingly digital world, the demand for efficient and reliable photodetectors is paramount. These devices are critical for a variety of applications, from medical imaging to defense systems. However, traditional photodetectors often struggle with low UV-visible rejection, limiting their e…

TS-063433 — A new pharmacologic modality for treating AFib.

TS-063238 — A novel regularization technique applicable for medical imaging applications that leverages conditional generative adversarial networks (cGANs) to generate reconstructed images in significantly shorter timeframes. The Need Several techniques are used for image reconstruction in the medical aren…

TS-063154 — Worldwide, 686,000 new head and neck (H&N) cancers are diagnosed yearly, and 375,000 people will die annually. Human papillomavirus (HPV) is responsible for an increasing subset of H&N malignancies called oropharyngeal squamous cell carcinomas (OPSCC). Although it has a better prognosis than…

TS-062900 — This cutting-edge technology redefines the intubation process by guiding the endotracheal tube into the airway with exceptional precision.

TS-062822 — Humanized Antibody-drugs conjugate for chemo-immunotherapy of multiple cancer types

TS-062715 — Radiopaque biodegradable polymer for the tracking of the breast tissue tumor cavity after lumpectomy and other radiation therapy applications

TS-062540 — General methods for purifying proteins that can be used in various applications such as targeted drug delivery, bioimaging, and hemolysis treatment.

TS-062505 — The Need Glaucoma and myopia are significant causes of vision loss worldwide, affecting millions of people and imposing a substantial socioeconomical burden. Effective vision care strategies are urgently needed to reduce blindness caused by these conditions and mitigate their associated risks. In v…

TS-062497 — The Need: The field of ophthalmology requires advanced diagnostic tools to effectively diagnose, prevent, and treat various eye conditions. While ultrasound imaging is well-known in fields like pregnancy check-ups and vascular imaging, its potential in ophthalmology remains largely untapped. There …

TS-062493 — Children whose heights or growth rates fall outside of the normal range can be identified as having short stature (less than the 3rd percentile) or tall stature (above the 97th percentile) or as having abnormal growth velocity. Serial height measurements over time are key to identifying these patt…

TS-062489 — Biosensors are a powerful and emerging technology capable of measuring the presence and concentration of molecules inside the human body. These devices are based on the premise that the physiology of diseased tissue is substantially different from that of healthy tissue and can be used to diagnose a…

TS-062482 — Magnetic Resonance Imaging (MRI) is a versatile noninvasive imaging tool that is routinely used to evaluate many diseases and conditions. MRI offers exquisite soft tissue contrast and high spatial resolution to enable comprehensive structural and functional assessment of internal organs. Recent innovations in data acquisition and processing can expand the clinical applications of MRI.

TS-062216 — The Need: Addressing Vascular Restenosis with Extended Drug Delivery Vascular restenosis poses a significant medical challenge in the United States, particularly in cases of coronary artery disease treated with bypass grafting. The current methods involve using drug-loaded polymer formulations to d…

TS-061547 — A venous access port device that leverages near-field communication (NFC) to automate needle placement as well as a disposable needle cartridge to increase the ease of and help maintain aseptic access to the port.

TS-060782 — Problem Statement: Diagnosis of arterial occlusion and an associated stroke can be lengthy, delaying patient access to treatment. As large vessel occlusions account for 24 to 46% of acute ischemic strokes and may require treatment in a comprehensive stroke center, early diagnosis is key. Solution:…

TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.

TS-054464 — Novel drug delivery system that enables efficient transfer of FDA-approved drugs for the treatment of neurological injuries.

TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.

TS-052847 — Back and neck pain is one of the world’s biggest health problems, and one which most people will experience during some stage in their lives. An estimated 80% of people will face this issue, although the severity of the pain may differ. Approximately 50 billion USD are spent by Americans eac…

TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.

TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.

TS-045092 — Shape memory alloys are metals that "remember" their original shape when deformed and can return to their initial shape when heated. These shape memory alloys cannot currently be welded to other alloys, which significantly limits their use. Current state-of-the-art methods of joining sha…

TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute

TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.

TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.

TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism

TS-041784 — A tool for simply and affordably assessing levels of certain household allergens and asthma triggers.

TS-041485 — A functionalized DNA nanostructure made through a scaffolded DNA origami molecular self-assembly process to deliver clinically significant concentrations of therapeutics.

TS-038384 — A novel device for monitoring cancer cell motility in real time using standard microscopy.

TS-038312 — A novel, intravitreal microparticle injection capable of controlled-release of protein therapies (including anti-VEGF) for tunable periods of 6-12 months after injection for the treatment of age-related macular degeneration.

TS-038028 — Transcatheter heart valve (THV) with novel leaflet materials and design profile that results in reduced thrombogenicity, improved durability, and lower manufacturing cost

TS-037944 — A new way to make a scaffold via tissue engineering that can also deliver drugs without compromising the scaffold.