"Flexible biomarker biofluid cell array for 2D/3D mapping of biomarker concentration levels"Measurement/detection of analytes (e.g., biomarkers) in different environments (e.g., biofluids/organs) is typically performed using a biosensor. Available bio-integrated sensors do not provide the capability to map biomarker concentrations, require a power source to function, use a limited number of electrodes, and normally can only measure a specific type of biofluid but not others. The use of glutamate mapping technology (radioactive or fluorescent ligand bound to a glutamate receptor) has been evaluated and found to require bulky/expensive medical equipment, a power source for measurement, cannot be miniaturized or integrated into a bio tissue, and require patients to be stationary during measurement. The Need To address concerns and limitations with current biomarker detection/ measurement technologies, an alternative, cost-effective, efficient biosensing system/device capable of 2D/3D mapping the concentrations of various biomarkers in different bio environments is required. The Technology A sensor has been developed with the ability to perform 2D/3D mapping of biomarker (e.g., neurotransmitters, hormones, nutrients, metabolites, others) concentrations in small areas. The sensor uses two electrodes (e.g., Pt black, Au, others) in contact with each other forming a conductive layer located on a flexible substrate and an active layer composed of oxidase and an electron mediator (e.g., TTF). A current is generated from the reaction of glutamate with glutamate oxidase resulting in a voltage with its amplitude proportional to glutamate concentration levels. Laboratory evaluations indicated good correlation/sensitivity between glutamate concentrations ranging from 0-1 mM and generated voltages. Commercial Applications
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Tech IDT2022-175 CollegeLicensing ManagerAshouripashaki, Mandana InventorsCategories |
