The Need
Current methods for mapping electrical potential gradients in biological tissues, such as the brain, rely on high-density electrode arrays fabricated via costly microfabrication techniques. These rigid devices struggle to conform to complex tissue morphologies, limiting their effectiveness for real-time, high-resolution physiological imaging and diagnostics. There is a critical need for adaptable, cost-effective sensors that provide detailed, quantitative data for disease diagnosis and research.

The Technology
This technology is a flexible, light-addressable potentiometric sensor fabricated using thin-film techniques. It leverages a focused light beam to precisely select and map sensing locations on the device surface, enabling high-resolution imaging of physiological signals. The sensor’s flexible substrate allows it to conform to irregular surfaces, such as organs or tissues, while its simplified manufacturing process eliminates the need for advanced lithography, reducing production costs and complexity.

Potential Commercial Applications
• Real-time neural activity mapping for brain-computer interfaces
• High-resolution cardiac electrophysiology monitoring
• Wearable biosensors for continuous health monitoring
• Advanced diagnostic platforms for tissue-level disease detection

Benefits/Advantages
• Flexibility: Conforms to complex tissue surfaces for improved contact and signal fidelity
• High Resolution: Light-addressable mapping achieves ~100 nm spatial resolution
• Cost-Effective Manufacturing: Thin-film process eliminates expensive lithography steps
• Versatility: Easily adapted for different analytes (ions, biomarkers) and application areas