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Advanced AAV Gene Therapy Characterization Technique
TS-062608 — Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight infection. These next-generation treatments hold promise for treating various genetic and chronic conditions, including but not limited to cancer, cystic …
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Cleary, Sean; Du, Chen
  • Licensing Officer: Dahlman, Jason "Jay"

Panoptic Ion Source for Comprehensive Mass Spectrometry Analysis
TS-062577 — The Need Traditional Mass Spectrometry (MS) methods require solid and liquid samples to be vaporized and charged before analysis, which can be limiting. Existing ion sources are often specialized for specific types of analytes, leading to inefficiencies and the need for multiple devices. There is a…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Amoah, Enoch; Chintalapudi, Kavyasree "Kavya"; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Unraveling Biomolecular Structures with Surface-Induced Dissociation Mass Spectrometry
TS-062550 — The Need: The need for surface-induced dissociation (SID) technology arises from the limitations of current mass spectrometric methods in studying the tertiary and quaternary structure of proteins and their complexes. While mass spectrometry is a powerful tool for structural biology, existing activa…
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Gilbert, Joshua; Harvey, Sophie; Jones, Benjamin; Stiving, Alyssa; VanAernum, Zachary "Zac"
  • Licensing Officer: Panic, Ana

Ion Carpet-Based Surface-Induced Dissociation Device
TS-062342 — The Need In the field of mass spectrometry (MS), the study of proteins and protein complexes in their native form, known as native MS, has become crucial in understanding their structure and function. However, the current collision-induced dissociation (CID) technique used in tandem MS experiments …
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Gilbert, Joshua; Stiving, Alyssa
  • Licensing Officer: Dahlman, Jason "Jay"

Next-Generation Contained Mass Spectrometry capable of On-line Solid-Phase Extraction and Atmospheric Pressure Chemical Ionization of Nonvolatile Solid and Liquid Complex Samples
TS-062340 — The Need There is a commercial need for an advanced ionization and analysis technology that can effectively and rapidly detect and analyze organic compounds, including both polar and non-polar ones, in various matrices. The current challenges in existing ambient mass spectrometry (MS) methods inclu…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

Thread-Based Immunoassay and Mass Spectrometry for Disease Biomarker Detection
TS-062337 — Background: Current immunoassay methods often rely on magnetic beads for sample collection and signal amplification, typically employing colorimetric detection based on enzymatic reactions. This approach raises stability concerns and is not ideal for field analysis due to the necessity of lasers fo…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Jackson, Sierra; Swiner, Devin
  • Licensing Officer: Panic, Ana

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Damon, Deidre
  • Licensing Officer: Panic, Ana

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