TS-076401 — Many progressive diseases, including cardiac, neurological, and other chronic disorders, begin with subtle molecular and cellular changes long before conventional clinical signs become detectable. Current diagnostic approaches generally identify disease only after significant tissue remodeling or …

TS-075918 — Rare earth elements (REEs) are essential for advanced manufacturing, energy technologies, electronics, and defense applications, yet their separation remains one of the most challenging and costly steps in the supply chain. Conventional separation methods often require extensive processing, hazard…

TS-075489 — Organizations across healthcare, government, finance, market intelligence, and regulatory sectors routinely generate large collections of reports containing valuable tabular data. While these reports often follow consistent formats, extracting, comparing, and analyzing information across multiple …

TS-075450 — Safety-critical systems in industries such as energy, aerospace, industrial automation, and advanced manufacturing are becoming increasingly complex, integrating hardware, software, controls, sensors, and communication networks. Existing fault analysis methods are often domain-specific and require…

TS-075184 — Problem Synthetic lethality (SL) is defined as a gene combination effect (GCE) of two genes where loss-of-function of both genes, rather than one, causes cell death. While carrying strong therapeutic potential in the treatment of cancer, SL interactions are context specific and sparse, thereby limi…

TS-075168 — Problem Metastasis is the primary driver of cancer-related deaths, yet accurately predicting its onset is a major clinical challenge. Current diagnostic tools often fail to detect occult metastatic cells and metastatic precursor cells, resulting in either overdiagnosis, with unnecessary treatments,…

TS-074669 — Current cardiac MRI workflows rely heavily on breath-holds, ECG gating, and retrospective binning, which break down in patients with arrhythmias, irregular breathing, or limited ability to cooperate. Existing 3D approaches often average away beat-to-beat variability or suffer from motion artifacts…

TS-074599 — Discovering molecules that simultaneously satisfy multiple competing design criteria is a resource-intensive challenge across the pharmaceutical, energy, and materials industries. The enormity of chemical space makes exhaustive screening impractical, while existing AI-guided methods either restric…

TS-074364 — Senior executives struggle to understand and prioritize cybersecurity risk in business terms. Existing vulnerability scoring systems rely on opaque or arbitrary measures that fail to connect cybersecurity decisions to financial impact, staffing costs, or operational tradeoffs. As a result, organiz…

TS-073932 — DEEP Phaser enables fully automated, expert level phase correction to improve NMR data quality, consistency, and throughput across routine and high-volume workflows. Problem Overview Accurate phase correction is essential for reliable NMR interpretation and quantitative analysis. Despite its impo…

TS-073841 — Current federated learning (FL) systems face significant challenges in efficiently aggregating model updates over wireless networks, especially in environments with diverse data and varying channel conditions. There is a critical need for a solution that enhances bandwidth efficiency, personalizat…

TS-073818 — Autonomous vehicles and advanced driver-assistance systems require extensive testing across rare, hazardous, and edge-case scenarios to ensure safety and regulatory readiness. Existing approaches (pure simulation, hardware-in-the-loop, proving grounds, or public-road testing) each suffer from trad…

TS-073768 — Electrified and hybrid vehicle powertrains are increasingly complex, integrating mechanical, electrical, thermal, and emissions subsystems with both continuous and discrete decision variables. Existing energy management and co‑optimization approaches typically rely on simplified models, sequenti…

TS-073587 — Magnetic nanoparticles are widely used in applications such as magnetic hyperthermia, catalysis, sensing, and data storage, yet their performance is often limited by poor control over key magnetic properties. Existing materials typically rely on size or shape control alone, which provides limited …

TS-073553 — Positioning, navigation, and timing (PNT) systems increasingly seek alternatives or complements to GNSS due to vulnerability to interference, jamming, and limited performance in challenged environments. While low Earth orbit (LEO) communication satellites offer strong signals and favorable geometr…

TS-073358 — Reliable positioning, navigation, and timing (PNT) in GNSS‑denied or disrupted environments remains a critical challenge for defense, transportation, and autonomous systems. While low Earth orbit (LEO) communications satellites offer powerful signals and rapid geometry changes, they are typicall…

TS-073339 — Positioning, navigation, and timing (PNT) resilience is increasingly critical as GNSS vulnerabilities become more apparent in contested, denied, or degraded environments. Low Earth orbit (LEO) communication satellites offer a promising alternative PNT source, but their utility is limited by poorly…

TS-073254 — Industries operating safety‑critical and asset‑intensive systems struggle to leverage the full value of disparate maintenance data sources. Current maintenance management and optimization tools operate in silos, limiting real‑time decision‑making, automation, and scalability. No existing s…

TS-073225 — In today's world, we are increasingly using low-cost devices with limited resources (often referred to as "edge devices") which are supported by connected high-performance servers. However, these edge devices often can't handle complex tasks such as classifying data. To make this possible, we need…

TS-073173 — Modern navigation systems increasingly rely on signals of opportunity such as 5G and LEO satellite downlinks, but these signals often lack public reference‑signal specifications, may be dynamic or on‑demand, and can suffer from severe Doppler effects. Conventional receivers cannot reliably acq…

TS-073146 — As industrial systems become increasingly digital and interconnected, traditional risk assessment tools struggle to capture how cyber threats interact with physical processes in real time. Existing methods typically assess hardware failures or isolated cyber events, but they cannot model how attac…

TS-073138 — Designing online monitoring (OLM) for safety‑critical systems is constrained by scarce early‑stage operational data and by quantitative models that are slow to build, brittle across configurations, and costly to iterate. This creates expensive sensor networks with blind spots, poor diagnosabil…

TS-073111 — Urban intersections are among the highest‑risk environments for automated and human‑driven vehicles due to occlusions, complex right‑of‑way, mixed traffic, and inconsistent connectivity. On‑board perception alone often misses beyond‑line‑of‑sight actors, while centralized or game 

TS-073103 — Physical protection remains a major driver of nuclear plant operations and maintenance costs, yet current security risk models rely on conservative assumptions and sparse empirical data on how defenders and operators actually behave under extreme threat. They rarely capture errors of commission, k…

TS-073031 — Operators of large, complex facilities struggle to balance revenue, maintenance, and regulatory safety constraints under uncertainty. Existing tools typically optimize only a subset of factors without a unified, real‑time view of component health and future degradation. Advanced reactors and oth…

TS-072175 — The Need Modern industrial and energy systems are increasingly complex, making timely fault detection and discrimination critical for safety, reliability, and cost control. Existing fault diagnosis methods often struggle with transient states, require extensive historical data, or lack interpretabil…

TS-071915 — An ultra‑efficient probit‑space ensemble expansion approach triples the size of weather‑forecast ensembles by producing hundreds of realistic “virtual” members from existing runs using minimal compute time and expert statistical knowledge.

TS-071386 — The Need The search for sustainable, high-performance battery materials is hindered by reliance on finite metal-based resources and slow, trial-and-error development cycles. Organic electrode materials (OEMs), composed of earth-abundant elements, offer a more sustainable path but present challenges …

TS-071385 — The Need Open source software is foundational to modern development, yet it introduces significant security risks due to outdated dependencies and inaccurate vulnerability advisories. Public databases often fail to identify all affected versions of software, leaving organizations exposed. With vulne…

TS-071267 — The Need Modeling solvent effects on catalytic surfaces is critical for designing industrial processes like biomass conversion, fuel synthesis, and electrocatalysis. Traditional multiscale simulations combining density functional theory (DFT) and molecular dynamics (MD) offer accuracy but are comp…

TS-070971 — The Need Modern gas turbines and compressors rely on bladed disks, which are highly sensitive to mistuning caused by manufacturing tolerances, wear, or damage. Existing modeling tools are fragmented, complex, and often limited to specific mistuning types. Industry will greatly benefit from a unified…

TS-070954 — The Need Intersections are among the most dangerous areas on U.S. roadways, accounting for approximately 25% of traffic fatalities and nearly half of all injuries annually. Vulnerable Road Users (VRUs), including pedestrians and cyclists, face increasing risk due to complex traffic dynamics and limi…

TS-070310 — An integrated soil health assessment and management platform that empowers growers to boost yields and sustainability through data-driven decisions.

TS-069654 — Technology bundle containing T2025-148 and T2024-150.

TS-069523 — The Need In many scientific and industrial fields, there is a critical need for interpretable and accurate models that can be derived from complex datasets. Traditional machine learning methods often produce black-box models that lack transparency and interpretability, making it difficult to unders…

TS-068440 — Accurate measurement of physical attributes, such as dimensions, alignments, and surface features, is essential for ensuring quality and consistency across industries. Traditional measurement methods, often reliant on manual tools and human oversight, are time-intensive, prone to errors, and lac…

TS-067792 — A software tool for optimizing the manufacturing process for metal alloys.

TS-067434 — The Need Spatial aggregation is crucial in numerous industries where data from low-level spatial units, such as census blocks, must be grouped into larger, meaningful regions. Traditional approaches often struggle with the computational complexity of these tasks and tend to focus on finding a singl…

TS-066058 — By adopting our AI-driven solution, engineering teams can achieve more in less time, push the boundaries of innovation, and significantly cut down costs, all while maintaining or increasing the reliability and accuracy of their structural and material analysis. This is not just an evolution in FEM technology—it's a revolution.

TS-065449 — The Need: Modern computational tasks demand efficient and resource-effective solutions. Traditional methods often fall short due to their high resource consumption and power requirements. Reservoir computing, while promising, has faced limitations in optimizing network topologies efficiently, hinder…

TS-065446 — The Need: In today's fast-paced commercial landscape, there's an increasing demand for rapid processing of complex data sets. Traditional computing methods often struggle to keep pace with real-time requirements, leading to inefficiencies and missed opportunities. Addressing this need for sw…

TS-065436 — The Need: In an era dominated by digital transactions and sensitive data exchanges, ensuring robust cybersecurity measures is paramount for individuals and organizations alike. Traditional methods of securing data often fall short in the face of sophisticated cyber threats, necessitating innovative …

TS-065412 — The Need: In contemporary cybersecurity landscapes, the conventional methods of employing Physically Unclonable Functions (PUFs) necessitate maintaining a secure challenge-response database. However, this practice poses significant security risks as access to this database could lead to the comprom…

TS-064578 — This software solution revolutionizes the process of tolerance stack analysis in mechanical assemblies. It automatically detects and extracts tolerance stacks as the foundational step for precise tolerance analysis and schema generation.

TS-063911 — Porosity formation during the solidification of aluminum-based alloys, induced by hydrogen gas and alloy shrinkage, presents a significant challenge for industries relying on high-performance solidification products such as castings, welds, and additively manufactured components. This issue advers…

TS-063308 — In today’s world, privacy and safety are paramount. Being followed by other vehicles during driving can be unnerving and potentially dangerous, leading to privacy leakage and even significant traffic accidents. There is a pressing need for a solution that can detect abnormal following vehicl…

TS-063239 — The Ohio State University has developed a vulnerability analysis technique for connected and autonomous vehicles that assesses the vulnerability and attackability of the automotive controllers to determine the security of the system. The Need Automated vehicle technologies improve safety, assis…

TS-063238 — A novel regularization technique applicable for medical imaging applications that leverages conditional generative adversarial networks (cGANs) to generate reconstructed images in significantly shorter timeframes. The Need Several techniques are used for image reconstruction in the medical aren…

TS-063154 — Worldwide, 686,000 new head and neck (H&N) cancers are diagnosed yearly, and 375,000 people will die annually. Human papillomavirus (HPV) is responsible for an increasing subset of H&N malignancies called oropharyngeal squamous cell carcinomas (OPSCC). Although it has a better prognosis than…

TS-063038 — The Need In the era of machine learning, high-stakes decisions are increasingly being made by black box models, leading to concerns about accountability and fairness. These models can exhibit inherent biases, raising the need for a system that ensures accountability and fairness in decision-making …