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Endoscopic additive manufacturing of biomaterials
TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients. This innovative technology T2019-145 is part of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing of biomaterials.
Robot-assisted surgery, tissue engineering, and additive manufacturing (AM) are emerging techniques in healthcare. Currently AM is used to develop synthetic tissues and organs, but open surgery is typically used to implant these scaffolds within the patient. This invasive procedure can subject pat…
  • College: College of Engineering (COE)
  • Inventors: Hoelzle, David; Asghari Adib, Ali; D'Souza, Desmond; Mansour, Daniel; Simeunovic, Andrej
  • Licensing Officer: Zinn, Ryan

Retrievable Stentgraft for Vascular Surgery and Regional Drug Delivery
TS-063006 — Medical device for vascular surgery and directed drug delivery
The Need Injuries involving hemorrhaging from the aorta, particularly in military and trauma settings, pose a significant threat to patients' lives. Current treatment options require clamping which completely restricts blood flow resulting in risks of complications such as coagulopathy and orga…
  • College: College of Medicine (COM)
  • Inventors: Tillman, Bryan; Kenawy, Dahlia
  • Licensing Officer: Schworer, Adam

Revolutionizing Vascular Access Management for Hemodialysis Patients
TS-062693 — Dynamic AVF flow control: A paradigm shift in vascular access management for hemodialysis patients.
Patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) face critical challenges in maintaining functional vascular access. Despite the superiority of arteriovenous fistulas (AVFs) in terms of longevity, infection rates, and cost-effectiveness, over a third of AVFs fail to mature a…
  • College: College of Medicine (COM)
  • Inventors: Boobes, Khaled
  • Licensing Officer: Schultz, Teri

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Schworer, Adam

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries.
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an arteriovenous (AV) fistula used in hemodialysis access has been estimated at $15,000/year. In bypass and AV fistula…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Taysavang, Panya

Prosthetic Heart Valve With Tri-Leaflet Design For Use In Percutaneous Valve Replacement Procedures
TS-038028 — Transcatheter heart valve (THV) with novel leaflet materials and design profile that results in reduced thrombogenicity, improved durability, and lower manufacturing cost
Heart valve (HV) therapy is the second most common cardiac intervention in the U.S. with transcatheter delivery the dominant surgical approach. Most procedures employ mechanical (MHV) or bioprosthetic (BHV) devices. However, MHVs involve a significant risk of thromboembolism and require lifelong a…
  • College: College of Engineering (COE)
  • Inventors: Dasi, Lakshmi; Yousefi Koupaei, Atieh
  • Licensing Officer: Bhatti, Hamid

Oxygen Sensing Nanofibers
TS-014967 — Nanofibers designed to quantify the oxygen content of a local environment for cell cultures and tissue-based applications such as a wearable technology wirelessly integrated into an electronic device used to estimate the efficiency of an individual's oxygen consumption.
Measurements of growth and activity of living cells are advantageous in a wide array of applications. Such measurements can be used to track tissue regeneration, phenotypic change, localized hypoxia, the testing and development of antibiotics and much more (Maria Strianese et al., Scott Lynn et al…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Xue, Ruipeng
  • Licensing Officer: Zinn, Ryan

Multi-carrier processing in auditory prosthetic devices
TS-014871 — Encoding strategy for improvement of speech understanding in a noisy environment for audiotory prosthetic devices.
There are about 275 million adults globally with moderate to severe hearing loss and 360 million adults with mild hearing loss. The current solutions to allow these people to hear better include hearing aids, hearing loss counseling, cochlear implants, alerting devices, and other communication aid…
  • College: College of Arts & Sciences
  • Inventors: Apoux, Frederic; Healy, Eric
  • Licensing Officer: Dahlman, Jason "Jay"

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