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Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
  • Licensing Officer: Willson, Christopher

Column-free Purification of Recombinant Proteins
TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat
  • Licensing Officer: Willson, Christopher

pH-sensitive inhibitor release system for corrosion protection
TS-062835 — Coatings are broadly used to protect metallic structures from corrosion. However, aggressive acidic and alkaline conditions can both develop locally on the coated metal surface due to corrosion, leading to the failure of the coated structure. Commonly used smart coatings use a timed release of spe…
  • College: College of Engineering (COE)
  • Inventors: Li, Chao; Frankel, Gerald "Jerry"; Guo, Xiaolei
  • Licensing Officer: Zinn, Ryan

Heteroatom doped Carbon Nanostructures for Electrocatalytic Chlorine and Bromine Production
TS-062692 — Chlorine is used in production of many products, such as many polymers like polyvinyl chloride, polyurethanes and chloroaromatics. It is also used extensively in pharmaceuticals, pesticides, fiber optics, hypochlorite bleaches, and other commodities. However, the current method of producing chlori…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Jain, Deeksha; Mamtani, Kuldeep
  • Licensing Officer: Zinn, Ryan

Novel Efficient Butanol Production without CO2 Emission
TS-062607 — Chemicals and fuels from renewable resources have gained global interest due to environmental issues, climate change, oil price and supply volatility, and decreasing nonrenewable fossil fuel sources. Butanol is a biofuel alternative that can provide a higher heating value, lower volatility, polarity…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Willson, Christopher

Method and device for determining virus titer by surface enhanced Raman scattering
TS-062346 — The ability to rapidly identify and determine virus titer is of utmost importance in numerous biomedical applications, ranging from gene editing to pharmaceutical and vaccine development. In the context of lentiviruses, which are widely used for cell reprogramming in immunotherapies, knowing the e…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Morder, Courtney
  • Licensing Officer: Willson, Christopher

Dual ligand systems for cross-coupling of challenging C(sp2) and C(sp3) electrophiles.
TS-059018 — An unusual series of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings of previously incompatible substrate combinations.
Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are desirable methodologies for C–C bond formation but are limited to specific substrate classes. Couplings of widely-available electrophiles such as aryl chlorides or triflates are currently unknown with any alkyl b…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Hamby, Taylor
  • Licensing Officer: Willson, Christopher

Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-058577 — Novel, transition metal-free catalysts capable of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Hodge, Kelsey
  • Licensing Officer: Willson, Christopher

Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-048726 — Novel, transition metal-free catalysts capable of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Hodge, Kelsey
  • Licensing Officer: Willson, Christopher

Activity Enhancement of Perovskite-Type Cathode Material
TS-044391 — A new ammonia production technology using an oxygen ion conductive solid oxide electrolyte cell (SOEC) reactor and a novel cathode material.
Ammonia is utilized in a variety of industries with 80% of produced ammonia used for fertilizer production. Most commercial ammonia is produced using the Haber-Bosch (HB) process, which requires high temperatures and pressures, resulting in high operational/production costs. The process typically us…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Deka, Dhruba Jyoti; Gunduz, Seval
  • Licensing Officer: Zinn, Ryan

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