TS-065855 — The Need: Breweries and malting facilities seek barley varieties that combine winter-hardiness, lodging resistance, early maturity, and high yield potential while meeting the stringent quality requirements of all-malt brewing. Meeting this demand ensures consistent and high-quality beer production, …

TS-065848 — The Need In today's dynamic agricultural landscape, there is an escalating demand for sustainable and high-yield crop varieties to meet global rubber production needs. Conventional rubber cultivation methods often face challenges such as susceptibility to diseases, environmental stress, and flu…

TS-065461 — The Need: In the field of modern biochemistry, the production of recombinant proteins in bacterial hosts like Escherichia coli is integral for both research and industrial applications. However, the traditional method of using antibiotics for selection in protein production is costly and contributes…

TS-065423 — Turbine aircraft engines (jet engines) are a type of propulsion system commonly used in aviation. These engines operate on jet propulsion, where air is drawn into the engine, mixed with fuel, ignited, and then expelled at high speed to generate thrust. Jet engines are used in commercial and military aircraft, as well as helicopters.

TS-065394 — The Need: In the dairy industry, combating Salmonella Dublin is crucial due to production losses and its impact on human health. Current detection methods, particularly culture-based techniques, are laborious, time-consuming, and lack sensitivity in environmental samples. As a result, treatment effe…

TS-064271 — The Need In the rapidly advancing landscape of life sciences, researchers and biotech companies face an escalating demand for reliable and versatile cell lines. The need for a specialized cell line that combines adaptability, reproducibility, and ease of use is paramount in accelerating breakthroug…

TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …

TS-064269 — The Need: In a world grappling with rising childhood obesity and environmental concerns, there is an urgent need for comprehensive interventions in schools to promote healthy eating habits and sustainable practices. U-CAN-EAT addresses this need by developing a supportive program that combines nutri…

TS-064267 — In the field of post-transcriptional gene regulation, understanding the functions of RNA-binding proteins is crucial for controlling cellular processes and development in organisms. However, the lack of reliable tools for studying these proteins in vivo, particularly in plant cells, has hindered p…

TS-063364 — Experience the future of advanced materials—our metal matrix composites offer a revolutionary approach to meeting the demands of modern industries. Elevate your products, enhance performance, and reduce costs with our groundbreaking technology. For a closely related technology, please visit https://oied.osu.edu/find-technologies and type "T2017-051" in the search field.

TS-063055 — New LWIR detector combining a dielectric resonator antenna (DRA) with a semiconductor absorber for improved signal, noise, and speed performance

TS-062968 — A novel method of creating catalytic material containing paired Lewis acids in combination with alkyl-metal precursors for improving the production of materials used in agricultural, chemical, and other commercial/industrial applications/processes.

TS-062834 — Road departure can be extremely dangerous for vehicles. Some vehicles are equipped with road departure mitigation systems to prevent this from happening. However, testing these systems can be difficult and costly, as it involves crashing vehicles into roadside objects. The concrete divider surr…

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TS-062691 — The continued push for high speed, low power, and compact solutions has given rise to the field of integrated optics/photonics, which aims to combine the high bandwidth and low loss transmission of fiber optic technology with the large device density and high production volume of modern microelect…

TS-062555 — The Need: Improved Nucleic Acid Detection Probes There is a growing need for advanced detection probes that can effectively identify target nucleic acid sequences while reducing binding to mismatched targets. Existing technologies often suffer from false positive results due to temperature fluctuat…

TS-062324 — The Need Metabolomics researchers face a critical challenge in identifying unknown components within complex metabolite mixtures. The absence of efficient and accurate methods hampers their ability to discover new metabolites in biological and biomedical samples. Existing technologies, such as expe…

TS-062311 — The Need: Early detection of eye disorders, such as amblyopia and myopia, is crucial for effective treatment and improved long-term outcomes, especially in children and young adults. Traditional screening methods for amblyopia often require specialized instruments and expertise, making them costly, …

TS-061876 — A novel method of creating catalytic material containing paired Lewis acids in combination with alkyl-metal precursors for improving the production of materials used in agricultural, chemical, and other commercial/industrial applications/processes.

TS-059018 — An unusual series of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings of previously incompatible substrate combinations.

TS-057780 — A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.

TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.

TS-057725 — The angle at which the gears of a turbine engine are staggered can be manipulated to neutralize harmonic excitations produced by the engine.

TS-054326 — Magnetic skyrmions are unique and stable magnetic spin structures extensively studied in condensed matter physics. They are actively being developed due to their potential application in advanced memory chips. These skyrmion-based memory structures have advantages such as high density, low energy consumption, and resistance to disturbances, making them an attractive option for next-generation data storage.

TS-054040 — This is a new method of resistance spot welding of aluminum alloy and advanced high strength steel that creates a stronger bond by using a chromium-rich interlayer. The interlayer improves joint strength, ductility, and toughness compared to traditional methods.

TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.

TS-050464 — Experience the future of fluidic control with our out-of-plane feedback-type fluidic oscillator. Revolutionize your engineering applications with unmatched precision, adaptability, and efficiency. Embrace innovation and elevate your industry standards with our groundbreaking bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port. This inventive technology T2018-374 is just one part of a larger, comprehensive suite of fluidic oscillator technologies offered by The Ohio State University for licensing. To learn more about our other designs, please visit https://oied.osu.edu/find-technologies and search using the term: Fluidic Oscillator.

TS-048641 — A method of authenticating an IC die’s origin and uniquely identifying each die with an intrinsic unclonable value through measurement of on-chip capacitance values

TS-047136 — A range of low-cost gas sensors for non-invasive diagnostic tests and health monitoring.

TS-046780 — Dr. Andre Palmer’s lab at The Ohio State University has developed a novel purification method to isolate any target protein from a complex mixture. The process purifies a target protein (TP) from a mixture by exploiting molecular size changes that result from the formation of a protein complex consisting of a TP and its TP binding molecule (TPBM). This is accomplished via Tangential Flow Filtration (TFF). This process allows for simple and scalable purification of any protein, providing a wide range of applicability.