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Vehicle-in-Virtual-Environment Method for Autonomous Driving System Development and Evaluation
TS-054005 — This technology is a Vehicle-in-Virtual Environment (VVE) method for testing and evaluating Autonomous Vehicles (AV). The VVE approach is a safe, reliable, repetitive, and scalable method of testing AVs, decreasing the risks and costs of testing AVs on public roads.
The demand for autonomous vehicles continues to grow as companies and cities realize the effect on the costs, safety, and efficiency that AVs have on everyday lives. Initiatives such as MCity in Detroit, Michigan, and Smart City in Columbus, Ohio, show a strong commitment to the development of aut…
  • College: College of Engineering (COE)
  • Inventors: Guvenc, Levent; Aksun Guvenc, Bilin
  • Licensing Officer: Zinn, Ryan

Therapeutic uses of the scavenging protein cocktail to treat plasma protein imbalances or depletion
TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Method for Preparing High-Energy Electrodes with Controlled Microstructures for Energy-Storage Devices
TS-052586 — A novel method for producing thick electrodes with controlled cracks to facilitate fast ionic transport and improve battery performance.
The Need Conventional electrodes for Li-ion batteries are prepared as thin layers of 70 to 100 microns to meet the power requirements of automotive applications. However, using thin electrodes compromises the energy densities of battery cells due to increasing weight and volume of inactive componen…
  • College: College of Engineering (COE)
  • Inventors: Kim, Jung Hyun; Rao, Lalith; Sayre, Jay
  • Licensing Officer: Sita, Cordellia

Mobile Harmful Contaminant Detection System: Home Health Kit for the detection of Allergens, Chemicals and Viruses
TS-052249 — A tool for simply and affordably assessing levels of certain household allergens (including asthma triggers), chemical contaminants (formaldehyde) and viruses (including SARS-CoV-2).
The Need Household allergens (including Asthma triggers) Asthma is one of the most common chronic conditions among children in the United States and a major cause of childhood disability. Despite advances in medical treatment, many children have poor asthma control that results in disruptions in s…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Parquette, Jonathan; Qin, Rongjun
  • Licensing Officer: Davis, Stewart

Dynamic Nanobiosensor Platform for Viral and Tumor Nucleic Acid Detection
TS-052072 — A rapid, nucleic acid-based, point-of-care diagnostic.
The current gold-standard molecular diagnostic assay, quantitative reverse transcriptase (RT)-PCR, although accurate, is labor intensive (5-step workflow) and time consuming. Due to centralized laboratory testing, the time to results for RT-PCR can vary from 1 day up to 2 weeks, depending on the s…
  • College: College of Engineering (COE)
  • Inventors: Halley, Patrick; Castro, Carlos; Lucas, Christopher; Marras, Alexander; Shahhosseini, Melika
  • Licensing Officer: He, Panqing

Novel Electrode for Co-factor Regeneration
TS-051995 — Method of regenerating NADPH for the production of biobutanol.
The Need NAD(P)H is used as a reducing co-factor for the synthesis of biochemicals (e.g., conversion of aldehydes to alcohols) using biocatalysts or even microbes. Butanol is an important feedstock used in the chemical industry and shows great potential as a biofuel. Butanol is produced from fossil…
  • College: College of Engineering (COE)
  • Inventors: Kadowaki, Jonathan; Gopalan, Venkat; Jones, Travis; Sengupta, Anindita; Subramaniam, Vishwanath
  • Licensing Officer: Sita, Cordellia

Novel Ergonomic Scalpel Handle
TS-051663 — Alleviate and prevent occupational stresses using this novel scalpel design.
A highly unfortunate outcome of the 2020 coronavirus pandemic is the over 400,000 American deaths that have unexpectedly overloaded medical autopsy services across the United States. With this heightened need for autopsy services previously unseen occupational hazards relating to repetitive motion…
  • College: College of Medicine (COM)
  • Inventors: Sachire, Jennifer
  • Licensing Officer: He, Panqing

Activation of human Argonaute3 (AGO3) using cityRNAs
TS-051298 — MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression post-transcriptionally. Their sequences differ, but their lengths fall within a range of ~20-23 nucleotides because the precursor miRNAs are processed by Dicer. Dicer cleaves long double-stranded RNA (dsRNA) molecules into s…
  • College: College of Arts & Sciences
  • Inventors: Nakanishi, Kotaro; Park, Mi Seul
  • Licensing Officer: Ezzell, Janel

Modular Dc Circuit Breaker with Integrated Energy Storage for Future Dc Networks
TS-051200 — Traditional AC distribution is not suitable for a wide range of applications in regard to efficiency, cost, and power carrying capacity compared to alternative distributions. Low voltage distribution suffers from high transmission losses due to higher current requirements necessitating thicker, he…
  • College: College of Engineering (COE)
  • Inventors: Wang, Jin; Na, Risha; Zhang, Yue
  • Licensing Officer: Hong, Dongsung

Development of a live attenuated vaccine for leishmaniasis using CRISPR technology
TS-051167 — Methods of production and use of modified Leishmania species and compositions of live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions.
Leishmaniasis is a neglected tropical disease caused by infection with protozoans of the 15 genus Leishmania that is transmitted by infected sand flies. Worldwide, an estimated 1 billion people are at risk of infection in tropical and subtropical countries, with up to 1.7 million new cases in 98 c…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay
  • Licensing Officer: Davis, Stewart

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