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Gas Sensors for Health Monitoring and Diagnostics
TS-047136 — A range of low-cost gas sensors for non-invasive diagnostic tests and health monitoring.
Exhaled human breath is a combination of hundreds of gases including inorganic molecules such as NO, NH3 or CO, and volatile organic molecules such as acetone, ethane, and isoprene. Some of these gases are produced by the body as the result of physiological processes. Known as ‘biomarkers&rs…
  • College: College of Engineering (COE)
  • Inventors: Gouma, Pelagia-Iren
  • Licensing Officer: Gooray, Arthur "Art"

Origami Kite: A Smart Morphing Airborne Wind Energy Systems (AWES) for Enhanced Power Generation
TS-047066 — A next-generation AWES with significantly enhanced energy production efficiency and mobility that integrates transformative approaches of new kite flight mechanisms with a deployable origami structural design, an intelligent launching system, and data-based optimal control algorithms
Among different airborne wind energy system (AWES) mechanisms, the Ground-Gen AWES, which converts mechanical energy into electrical energy on the ground, has attracted increasing attention from both research institutes and industry because of their low cost, less complicated construction compared…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Ruike; Dai, Ran; Fang, Wen; Jung, Myungjin; Ze, Qiji; Zhang, Rundong
  • Licensing Officer: Hong, Dongsung

ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Aanstoos, Megan

Isolation of an Ohio Porcine Epidemic Diarrhea Virus (PEDV) PC22A Strain in Cell Culture
TS-046905 — Porcine epidemic diarrhea virus (PEDV) has historically been an exotic disease to the U.S.. As of May, 2013, the virus made its way from China to the U.S.. This virus causes nearly 100% mortality in piglets and ranges from 80-90% morbidity. There is currently no PEDV vaccine in production. This inve…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda; Oka, Tomoichiro; Wang, Qiuhong
  • Licensing Officer: Dahlman, Jason "Jay"

Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Novel spectroscopic sensor for screening nutritional and quality traits of field crops
TS-046751 — A novel sensor for the screening of field crops, one example being the amino acids in soybeans. This allows the quality and nutritional value of the soybeans to be evaluated quickly and simply. This technology would benefit not only farmers and producers of soybeans and soy products, but also consumers by manufactures to know the quality of the ingredients received to be monitored.
Nutritional components of soybeans, specifically their amino acid profiles, are important when evaluating the quality of soybeans. Currently, the only methods for evaluating soybean nutritional traits are to either send samples to a lab for testing, which is costly and takes several weeks to compl…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rodriguez-Saona, Luis; Ball, Christopher; Krishna, Sanjay; Ronningen, Theodore; Sia, Amanda
  • Licensing Officer: Flammang, Ann Marie

Novel Phosphors for Solid-State Lighting Applications
TS-046581 — Novel halide perovskite phosphor that, when paired with blue LED light, creates warm white light without the need for high temperature ceramics in its production and does not contain rare-earth elements. It has several applications including solid-state lighting and white LEDs. The phosphors produce light with a natural appearance and extended excitation spectra.
Phosphors are used in a variety of products and for a variety of reasons. Halide perovskite phosphors, a specific type of phosphor, can be combined with light emitting diodes (LED) to create phosphor converted LEDs (pc-LED). The current technology has several shortcomings; deficiency in red and cy…
  • College: College of Arts & Sciences
  • Inventors: Woodward, Patrick; Gray, Matthew; Majher, Jackson
  • Licensing Officer: Hong, Dongsung

Therapeutic uses of the apohemoglobin-haptoglobin complex
TS-046454 — Original, synthetic complexes used to detoxify hemoglobin, heme, and free iron in patients suffering from hemolysis. The use of these complexes would allow effective treatment of various states of hemolysis and would mitigate the numerous side effects associated with the condition. Complexes could also be used as a drug carrier for targeting CD163+ macrophages and monocytes.
Hemolysis is a burgeoning health condition that results from various pathophysioloigical conditions. It is characterized by the rupture of red blood cells, which release toxic, cell-free hemoglobin into the bloodstream. The cell-free hemoglobin further break down into heme and apoglobin, which cau…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Next-generation method for flow estimation and geospatial mapping of agricultural particulates
TS-046029 — Next-generation agricultural sensor technology enables precise, data-based decision-making to be implemented at the farm level. Field operations data such as granular fertilizer application rates are useful to the producer, because optimization of nutrient supplementation increases use efficiency …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Colley III, Richard; Fulton, John
  • Licensing Officer: Dahlman, Jason "Jay"

Compact Cas9-based transcriptional regulators for in vivo gene regulation
TS-045681 — Cas9-derived constructs can be used to modulate gene expression, but physical limitations restrict the application of this technique. Researchers at The Ohio State University have overcome this obstacle by engineering new Cas9-derived transcription factors.
CRISPR/Cas9 systems have revolutionized the field of programmable DNA technology. Recently, a version of the Cas9 protein with a deactivated nuclease domain called “dCas9” was developed. Without this domain, dCas9’s range of activity is limited to recognizing and binding sequence…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Dahlman, Jason "Jay"

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