Dust Analysis: A Novel Approach to Monitoring Viral Spread
TS-066962 — The Need
Viral disease surveillance (e.g. influenza, SARS-CoV-2) in high-risk settings faces several challenges, such as asymptomatic carriers, incomplete reporting, resource limitations, and delayed diagnosis of traditional swab test methods. These challenges could allow a virus to silently spread…
- College: College
of
Engineering
(COE)
- Inventors: Dannemiller, Karen; Faith, Seth; Hull, Natalie; Nastasi, Nick; Renninger, Nicole
- Licensing Officer: Ashouripashaki, Mandana
Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab
Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
- College: College
of
Engineering
(COE)
- Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
- Licensing Officer: Schworer, Adam
Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide.
The Need
Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
- College: College
of
Engineering
(COE)
- Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
- Licensing Officer: Willson, Christopher
How Are You Feeling Today? Organizational Mental Health Indicator and Real-Time Help Application
TS-064244 — The Need: Organizations, particularly college campuses, are facing a growing challenge in addressing student mental health issues. The rising prevalence of severe psychological problems, anxiety disorders, and depression among students necessitates a proactive and effective solution. The existing ga…
- College: College
of
Engineering
(COE)
- Inventors: Ezell, Jonathan; Kaufman, Michael
- Licensing Officer: Dahlman, Jason "Jay"
Skin Healing Technology: Dermal Substitutes and Engineered Skin with Rete Ridges
TS-064046 — Dermal substitute with engineered rete ridges improves epidermal-dermal communication and enhances burn wound treatment.
Massive burn injuries present a critical challenge in wound healing and prevention of infection. Current treatment methods are susceptible to blistering and other problems that can reduce engraftment.
The Need
Cultured epithelial autografts (CEAs) are a vital component in treating large burns, but…
- College: College
of
Engineering
(COE)
- Inventors: Powell, Heather; Bailey, John; Blackstone, Britani "Niki"
- Licensing Officer: Willson, Christopher
Adjustable Squatting Device for Constipation
TS-063959 — The Need
Millions of individuals suffer from constipation due to the inability to relax pelvic floor muscles during bowel movements, leading to discomfort and strained efforts. Current solutions, like the Squatty Potty, lack adjustability and portability, limiting their effectiveness for a diverse …
- College: College
of
Engineering
(COE)
- Inventors: Ruegsegger, Mark; Chakraborty, Subhankar; Gluzman, Isabella; Li, Yiqun; Piatkowski, Stephen; Puri, Raima
- Licensing Officer: Bhatti, Hamid
Endoscopic additive manufacturing of biomaterials
TS-063919 — An articulating end effector for additive manufacturing that utilizes robot-assisted endoscopic surgery to implant synthetic tissues at local defects through “keyhole” incisions in patients.
This innovative technology T2019-145 is part
of a portfolio that also includes T2017-363. To learn more about both technologies, please visit https://oied.osu.edu/find-technologies and search using the phrase: Endoscopic additive manufacturing
of biomaterials.
Robot-assisted surgery, tissue engineering, and additive manufacturing (AM) are emerging techniques in healthcare. Currently AM is used to develop synthetic tissues and organs, but open surgery is typically used to implant these scaffolds within the patient. This invasive procedure can subject pat…
- College: College
of
Engineering
(COE)
- Inventors: Hoelzle, David; Asghari Adib, Ali; D'Souza, Desmond; Mansour, Daniel; Simeunovic, Andrej
- Licensing Officer: Zinn, Ryan
Protecting the vascular endothelial barrier – a novel approach to treating atrial fibrillation
TS-063433 — A new pharmacologic modality for treating AFib.
Atrial fibrillation (AF) is the most common form of irregular cardiac rhythm (arrhythmia), affecting approximately 3% of the US population. It is a significant risk factor for heart failure, ischemic stroke, and sudden cardiac death. The AF mortality rate is growing globally, and risk factors known …
- College: College
of
Engineering
(COE)
- Inventors: Veeraraghavan, Rengasayee; Mezache, Louisa
- Licensing Officer: Willson, Christopher
Convolutional Neural Network to Assess Phayngeal and Laryngeal Pathology and Function on Nasopharyngolaryngoscopy
TS-063154 — Worldwide, 686,000 new head and neck (H&N) cancers are diagnosed yearly, and 375,000 people will die annually. Human papillomavirus (HPV) is responsible for an increasing subset of H&N malignancies called oropharyngeal squamous cell carcinomas (OPSCC). Although it has a better prognosis than…
- College: College
of
Engineering
(COE)
- Inventors: Krening, Samantha; Gifford, Ryan; Jhawar, Sachin; VanKoevering, Kyle
- Licensing Officer: Hampton, Andrew
Thermotropic liquid crystal-based sensors for naked-eye detection of SARS-CoV-2 with ultrahigh sensitivity and selectivity
TS-063069 —
In the wake of the global pandemic caused by SARS-CoV-2, the need for rapid, accurate, and efficient diagnostic methods for respiratory viral infections has become more critical than ever. Traditional diagnostic methods, while reliable, are often time-consuming, labor-intensive, and lack the neces…
- College: College
of
Engineering
(COE)
- Inventors: Wang, Xiaoguang; Qin, Rongjun; Rather, Adil; Xu, Yang
- Licensing Officer: Randhawa, Davinder
Automated Endotracheal Intubation
TS-062900 — This cutting-edge technology redefines the intubation process by guiding the endotracheal tube into the airway with exceptional precision.
The Need
Intubation is a critical medical procedure used to assist patients with breathing difficulties, executed through the insertion of an endotracheal tube (ET) into the windpipe. With over 313 million annual intubation procedures worldwide, ensuring first-pass success and minimizing complicati…
- College: College
of
Engineering
(COE)
- Inventors: Ruegsegger, Mark; Elsayed-Awad, Hamdy; Hopping, Ethan; Lopez Vogler, Christian; Miles, Tim; Peiffer, Jordan
- Licensing Officer: Bhatti, Hamid
Dual-payload Humanized Antibody-Drug Conjugate (DualADC) for targeted chemo-immunotherapy
TS-062822 — Dual payload ADC chemo-immunotherapy and Humanized mAb for cancer treatment
The Liu Lab
Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene ther…
- College: College
of
Engineering
(COE)
- Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
- Licensing Officer: Schworer, Adam
Tracking Breast Tissue Tumor Cavity after Lumpectomy
TS-062715 — Radiopaque biodegradable polymer for the tracking
of the breast tissue tumor cavity after lumpectomy and other radiation therapy applications
Approximately 40% of women diagnosed with breast cancer undergo a lumpectomy procedure. Approximately 170,000 lumpectomie are performed each yaer in the United States. Typically, this operation is followed by radiation therapy to ensure there are no remaining cancerous cells in the region. It is t…
- College: College
of
Engineering
(COE)
- Inventors: Metzler, Sandra; Elisha, Deji; Evans, Izzy; Fedro, Joseph; Krakovsky, Mia; Sherry, Adam; Skoracki, Roman
- Licensing Officer: Zinn, Ryan
Purification of apoproteins and general methods for protein purification
TS-062540 — General methods for purifying proteins that can be used in various applications such as targeted drug delivery, bioimaging, and hemolysis treatment.
The Need
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable sol…
- College: College
of
Engineering
(COE)
- Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
- Licensing Officer: Schworer, Adam
Methods to measure biophysical attributes of the posterior eye
TS-062505 — The Need
Glaucoma and myopia are significant causes of vision loss worldwide, affecting millions of people and imposing a substantial socioeconomical burden. Effective vision care strategies are urgently needed to reduce blindness caused by these conditions and mitigate their associated risks. In v…
- College: College
of
Engineering
(COE)
- Inventors: Liu, Jun; Kwok, Sunny
- Licensing Officer: Randhawa, Davinder
Methods for quantifying the biomechanical attributes of the cornea and the anterior sclera
TS-062497 — The Need:
The field of ophthalmology requires advanced diagnostic tools to effectively diagnose, prevent, and treat various eye conditions. While ultrasound imaging is well-known in fields like pregnancy check-ups and vascular imaging, its potential in ophthalmology remains largely untapped. There …
- College: College
of
Engineering
(COE)
- Inventors: Liu, Jun; Kwok, Sunny
- Licensing Officer: Randhawa, Davinder
ANTENNA-IMPREGNATED FABRICS FOR RECUMBENT HEIGHT MEASUREMENT
TS-062493 —
Children whose heights or growth rates fall outside of the normal range can be identified as having short stature (less than the 3rd percentile) or tall stature (above the 97th percentile) or as having abnormal growth velocity. Serial height measurements over time are key to identifying these patt…
- College: College
of
Engineering
(COE)
- Inventors: Kiourti, Asimina; Militello, Lisa
- Licensing Officer: Randhawa, Davinder
A novel computational procedure for accelerated, calibrationless magnetic resonance image reconstruction (Free-breathing Accelerated MRI Portfolio)
TS-062487 — Magnetic Resonance Imaging (MRI) is a versatile noninvasive imaging tool that is routinely used to evaluate many diseases and conditions. MRI
offers exquisite s
oft tissue contrast and high spatial resolution to enable comprehensive structural and functional assessment
of internal organs. Recent innovations in data acquisition and processing can expand the clinical applications
of MRI.
The Need
A major limitation of MRI is slow data acquisition, which can compromise patient comfort, drive up costs, and increase susceptibility to motion. The clinical adoption of volumetric imaging for musculoskeletal and neuro applications, the growing
demand for free-breathing real-time imaging …
- College: College
of
Engineering
(COE)
- Inventors: Zhao, Shen; Ahmad, Rizwan; Potter, Lee
- Licensing Officer: Randhawa, Davinder
Localized Cylindrical Drug Delivery to Prevent Vascular Restenosis
TS-062216 — The Need: Addressing Vascular Restenosis with Extended Drug Delivery
Vascular restenosis poses a significant medical challenge in the United States, particularly in cases of coronary artery disease treated with bypass grafting. The current methods involve using drug-loaded polymer formulations to d…
- College: College
of
Engineering
(COE)
- Inventors: Lannutti, John
- Licensing Officer: Dahlman, Jason "Jay"
Automatic Implanted Port Access Device
TS-061547 — A venous access port device that leverages near-field communication (NFC) to automate needle placement as well as a disposable needle cartridge to increase the ease
of and help maintain aseptic access to the port.
Venous access ports are central venous access devices that allow healthcare practitioners easy access to the patient’s veins to give treatment and take blood. Typically, these ports are made of non-irritant material and can remain under the skin for weeks or months.
The Need
Accessing a …
- College: College
of
Engineering
(COE)
- Inventors: Garcia, Jodi; Johnson, Trey; Purdom, Kellie; Weiss, Solomon; Weiss, Simon; Yuhasz, Ben
- Licensing Officer: Bhatti, Hamid
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