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High-strength/high-ductility magnesium sheet alloy for room-temperature forming
TS-048065 — A new magnesium alloy designed using computational thermodynamic and kinetic models, which possesses optimal mechanical and formability performance suitable for industrial applications
Magnesium (Mg), the lightest structural metal, and its alloys, with their high specific strength and low density, are promising lightweight materials for industrial applications in automotive, aerospace, and electronic sectors. A 2019 report by Business Communications Company (BCC) Research highli…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua (Alan); Shi, Renhai
  • Licensing Officer: Zinn, Ryan

Integrated Biomanufacturing System for Fiber-Reinforced Tissue Composites
TS-047830 — An automated technique and system which combines electrospinning, additive manufacturing, and cell dispensing for generating high-quality tissue constructs with high physiological relevance.
Recent advances in biofabrication introduced by additive manufacturing/3D printing (AM/3DP) have significantly improved the overall architecture control in tissue engineered constructs. These constructs have a wide variety of important research and clinical applications including, but not limited …
  • College: College of Engineering (COE)
  • Inventors: Zhang, Xu; Herderick, Edward; Niu, Ye "Ye"; Zhao, Yi
  • Licensing Officer: Zinn, Ryan

3D subwavelength photonic detector coupled with dielectric resonator antenna
TS-047335 — New IR detector combining a dielectric resonator antenna (DRA) with a semiconductor absorber for improved signal, noise, and speed performance
The three essential characteristics of detectors are signal, noise, and speed. There are inherent trade-offs in these three figures of merit and various applications emphasize one or more characteristics. The primary limitation for infrared detectors and imagers is the limit on the achievable sign…
  • College: College of Engineering (COE)
  • Inventors: Krishna, Sanjay; Ball, Christopher; Grbic, Anthony; Kazemi, Alireza; Ranjbar, Amin; Ronningen, Theodore; Shu, Qingyuan
  • Licensing Officer: Hong, Dongsung

Fast and Efficient Cross Band Wireless Channel Prediction Using Machine Learning
TS-047296 — A neural network that utilizes a simple and efficient single antenna optimization framework
Systems that use different frequency bands for uplink and downlink communication often need feedback between the clients to exchange band-specific channel information. The current state-of-the-art approach predicts the downlink channel based on the uplink channel by identifying certain variables u…
  • College: College of Engineering (COE)
  • Inventors: Srinivasan, Kannan; Bakshi, Arjun; Parthasarathy, Srinivasan
  • Licensing Officer: Hong, Dongsung

Gas Sensors for Health Monitoring and Diagnostics
TS-047136 — A range of low-cost gas sensors for non-invasive diagnostic tests and health monitoring.
Exhaled human breath is a combination of hundreds of gases including inorganic molecules such as NO, NH3 or CO, and volatile organic molecules such as acetone, ethane, and isoprene. Some of these gases are produced by the body as the result of physiological processes. Known as ‘biomarkers&rs…
  • College: College of Engineering (COE)
  • Inventors: Gouma, Pelagia-Iren
  • Licensing Officer: Gooray, Arthur "Art"

Origami Kite: A Smart Morphing Airborne Wind Energy Systems (AWES) for Enhanced Power Generation
TS-047066 — A next-generation AWES with significantly enhanced energy production efficiency and mobility that integrates transformative approaches of new kite flight mechanisms with a deployable origami structural design, an intelligent launching system, and data-based optimal control algorithms
Among different airborne wind energy system (AWES) mechanisms, the Ground-Gen AWES, which converts mechanical energy into electrical energy on the ground, has attracted increasing attention from both research institutes and industry because of their low cost, less complicated construction compared…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Ruike; Dai, Ran; Fang, Wen; Jung, Myungjin; Ze, Qiji; Zhang, Rundong
  • Licensing Officer: Hong, Dongsung

ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Aanstoos, Megan

Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Therapeutic uses of the apohemoglobin-haptoglobin complex
TS-046454 — Original, synthetic complexes used to detoxify hemoglobin, heme, and free iron in patients suffering from hemolysis. The use of these complexes would allow effective treatment of various states of hemolysis and would mitigate the numerous side effects associated with the condition. Complexes could also be used as a drug carrier for targeting CD163+ macrophages and monocytes.
Hemolysis is a burgeoning health condition that results from various pathophysioloigical conditions. It is characterized by the rupture of red blood cells, which release toxic, cell-free hemoglobin into the bloodstream. The cell-free hemoglobin further break down into heme and apoglobin, which cau…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Swindle-Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Flammang, Ann Marie

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Dahlman, Jason "Jay"

Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming "Shawn"; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

Louie: An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
TS-043077 — An Augmented Reality Sensory Trigger Wayfinding System for People with Autism
Millions of people on the Autism spectrum face challenges getting from place to place due to sensory sensitivities to sounds, sights, smells, tastes, physical feelings, and crowds. Due to these triggers, people with Autism have a strong need to know where they are going and what will be there so t…
  • College: College of Engineering (COE)
  • Inventors: Ezell, Jonathan; Kaufman, Robert; Kaufman, Michael
  • Licensing Officer: Aanstoos, Megan

A Bi-layered Capsule for Sustainable Delivery of Protein Therapeutics
TS-042858 — A biodegradable drug delivery system for the treatment of disease, especially ophthalmic diseases including age-related macular degeneration (AMD). The device will be injected and can control drug release for at least 6 months following the initial injection.
Retinal diseases can be extremely difficult to monitor once procedures have been initiated. AMD is the fourth most common causes of blindness and requires monthly injections to manage the effects of the disease and prevent permanent blindness. However, receiving recurrent injections can potentiall…
  • College: College of Engineering (COE)
  • Inventors: Jiang, Pengfei; Coutinho da Silva, Marco; Lannutti, John; Ohr, Matthew; Swindle-Reilly, Katelyn
  • Licensing Officer: Flammang, Ann Marie

Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics.
TS-042531 — A computational platform for forecasting the state of evolving systems and processes.
Particle methods are a class of computational algorithms used to estimate potential outcomes of a system or process. Although popular for their simplicity and scalability, the use of fixed sized "particle ensembles" renders the simulations unable to provide performance guarantees in quan…
  • College: College of Engineering (COE)
  • Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
  • Licensing Officer: Zinn, Ryan

Quantum Well Design for Red-Emitting InGaN LEDs
TS-042441 — The quantum well design is incorporated within a red-emitting InGaN QW LED, an LED type that usually cannot efficiently emit wavelengths larger than blue/green. The LED can be incorporated into a same-material RGB platform for white LEDs, because the well design increases efficiency and decreases indium composition compared to similar wavelength InGaN LEDs.
Blue-emitting InGaN quantum well (QW) LEDs now have 69% external quantum efficiency, but increasing the emitted-wavelength decreases the efficiency significantly. The inversion asymmetry of the InGaN lattice increases the induced strain, which in turn increases the piezoelectric effect. Charge bui…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Karim, Md Rezaul
  • Licensing Officer: Hong, Dongsung

Field Effect Transistor for High Power Millimeter-Wave Applications
TS-042088 — Transistor structure with high breakdown voltage at high frequency operation
A new generation of high throughput, efficient communication networks and sensors can be enabled through the use of millimeter scale wave regimes. However, current semiconductor materials (such as AlGaN/GaN) have a reduction in breakdown voltage as operating frequency increases, which leads to low…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Wang, Caiyu; Xia, Zhanbo
  • Licensing Officer: Hong, Dongsung

Amine-Containing Facilitated Transport Membranes For Carbon Dioxide/Nitrogen Separation
TS-041856 — Novel membrane technology utilizing active transport for carbon dioxide/nitrogen separation. The membrane exhibits high permeance and selectivity
Improved separation of by-product carbon dioxide from nitrogen in power plants and industrial exhaust systems would considerably decrease greenhouse gas emissions. The current method of separation that is most often used in industry is amine absorption, however this method is costly, has a large c…
  • College: College of Engineering (COE)
  • Inventors: Ho, W.S. Winston; Han, Yang
  • Licensing Officer: Bartell, Cordellia

DAtAnchor: A Multi-Layer Data Loss Mitigation System
TS-041846 — An alternative to traditional data security measures. The technology effectively "anchors" the information to one location, allowing for better security and making it harder to compromise access.
Data breaches are a looming risk for organizations that maintain significant repositories of sensitive data. The fundamental reason behind their inability to prevent them is the philosophy behind the current paradigm in data security: prevent all breaches at all times. Towards that end, existing a…
  • College: College of Engineering (COE)
  • Inventors: Koksal, C. Emre
  • Licensing Officer: Hong, Dongsung

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