TS-065862 — The Need In the landscape of cancer treatment, the emergence of immunotherapy has shown remarkable promise. However, its efficacy is not universal across all cancer types, and resistance development poses a significant challenge. Hyperprogression, characterized by accelerated tumor growth, further …

TS-065860 — The Need: Cancer remains one of the most pressing medical challenges of our time, demanding innovative solutions to enhance treatment efficacy while minimizing systemic toxicity. Conventional chemotherapy agents often suffer from poor solubility, instability, and indiscriminate cytotoxicity, necessi…

TS-065845 — The Need: In the realm of biotechnology, the challenge of synthesizing enzymes, pharmaceuticals, and fine chemicals efficiently is paramount. However, the presence of multiple proteases secreted by Bacillus subtilis 168 during growth stages poses a significant obstacle to achieving optimal productio…

TS-065844 — The Need: In modern biotechnology and pharmaceutical industries, precise control over gene expression is paramount. However, conventional translation processes often lead to inefficiencies, resulting in reduced yields and compromised protein function. Meeting the demand for enhanced gene expression …

TS-065835 — The Need: In the realm of genomic research, the ability to accurately annotate transposable elements (TEs) within large, repetitive genomes is paramount. Existing methods for TE annotation lack systematic comparison, leaving a gap for a comprehensive pipeline to generate non-redundant TE libraries f…

TS-065461 — The Need: In the field of modern biochemistry, the production of recombinant proteins in bacterial hosts like Escherichia coli is integral for both research and industrial applications. However, the traditional method of using antibiotics for selection in protein production is costly and contributes…

TS-065460 — The Need Cancer remains one of the most pressing medical challenges worldwide, necessitating novel therapeutic approaches to combat its proliferation. Despite advancements, targeted therapies are often limited by immune responses or cumbersome production processes. There's a growing demand for …

TS-065459 — The Need The emergence of HIV-1 infection continues to pose significant challenges in healthcare worldwide. Current treatment approaches primarily target viral components, leading to the development of drug resistance over time. There is a pressing need for innovative therapeutic strategies that di…

TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…

TS-065456 — The Need In modern biological research, there is a pressing demand for technologies that enable precise mapping of RNA-protein interactions within Ribonucleoprotein (RNP) complexes. Traditional methods often lack the capability to pinpoint these interactions at the level of secondary structure moti…

TS-065455 — The Need: In modern biotechnology and biomedical research, there is an escalating demand for efficient tools that can accurately detect and analyze specific RNA sequences. The ability to precisely target and identify RNA molecules, particularly U-rich sequences, is crucial for various applications s…

TS-065416 — The Need: In the rapidly advancing realm of quantum information science, there's an escalating demand for reliable sources of entangled photon pairs. These photon pairs serve as fundamental building blocks for various quantum communication technologies. Presently, maintaining these sources neces…

TS-065414 — The Need: Innovations in the field of quantum technology are paramount to addressing the escalating demand for advanced computational capabilities and sensitive sensor applications. As traditional computing methodologies reach their limits, there arises an urgent commercial need for breakthroughs i…

TS-065412 — The Need: In contemporary cybersecurity landscapes, the conventional methods of employing Physically Unclonable Functions (PUFs) necessitate maintaining a secure challenge-response database. However, this practice poses significant security risks as access to this database could lead to the comprom…

TS-065143 — The Need: In the face of pressing environmental concerns and the imperative for sustainable energy solutions, there arises a critical commercial need for systems and methods that can efficiently produce hydrogen (H2) while simultaneously capturing and converting carbon dioxide (CO2) emissions. Trad…

TS-064834 — The Need: Colorectal cancer remains a significant global health challenge, particularly when it metastasizes to the liver. Accurate and rapid diagnosis of metastatic liver lesions is crucial for effective treatment planning and patient outcomes. Traditional diagnostic methods often lack the specific…

TS-064832 — The Need: The chemical composition of the sea surface microlayer (SSML) plays a crucial role in various environmental processes, impacting atmospheric chemistry and oceanic dynamics. However, traditional analytical methods struggle to efficiently characterize the complex and variable composition of …

TS-064831 — The Need: Urban historians, city planners, and preservationists require efficient tools to extract building-level information from historic Sanborn Fire Insurance maps, essential for understanding urban development over time. However, manual extraction is time-consuming and impractical due to the sh…

TS-064828 — The Need: Transition metal-catalyzed hydroelementation reactions address a critical demand in various industries by facilitating the addition of H-E (E = H, Si, B) across C-C double bonds. These reactions are vital in the chemical sector, particularly in the petrochemical, pharmaceutical, agrochemic…

TS-064827 — The Need: As the second quantum revolution progresses, the demand for robust quantum materials intensifies, particularly in the realm of quantum computation and information processing. Addressing the challenges of coherence and stability in qubits is crucial for advancing quantum technology towards …

TS-064826 — The Need Accurate measurements of energy and time-of-arrival of photons, particles, or ionizing radiation are crucial for identifying individual particles and enhancing spatial and temporal resolution in various systems. Technologies such as Light Detection and Ranging (LiDAR), positron emission to…

TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…

TS-064823 — The Need: In the burgeoning field of quantum computing, the primary commercial challenge lies in maintaining the integrity of quantum bits (qubits) amidst environmental interactions. Traditional methods struggle to prevent decoherence, hindering the scalability and reliability of quantum systems. Ad…

TS-064586 — Speech corpus of regional dialect variation in American English documenting changing pronunciation patterns across several generations of speakers ranging in age from 8 to 101 years old. The Need The speech corpus can be used for research on variation and change in spoken language, for the deve…

TS-064585 — COLMARppm offers a swift and accurate solution to the longstanding challenges in metabolomics research. Unique features and capabilities position it as a crucial tool for researchers seeking to unlock unknown metabolites, contributing to health research The Need In the field of metabolomics resear…

TS-064581 — Antibodies are essential therapeutic modalities for treating a plethora of different diseases, ranging from cancer, autoimmune disorders, degenerative diseases, and inflammation. The FDA approved the first antibody over three decades ago, and since more than 570 have been studied in clinical trials,…

TS-064577 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately only 40% living past the first-year post-diagnosis and 17% in the second year. The Need Developing drugs for cance…

TS-064299 — Mass spectrometry (MS) is used across a wide range of applications involving analytical chemistry. Various MS techniques, often coupled with liquid chromatography (LC), allow for detection of various chemical analytes, from drug metabolites, pesticides, food adulterants, and natural product extracts…

TS-064271 — The Need In the rapidly advancing landscape of life sciences, researchers and biotech companies face an escalating demand for reliable and versatile cell lines. The need for a specialized cell line that combines adaptability, reproducibility, and ease of use is paramount in accelerating breakthroug…

TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …