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New vector for simultaneous gene silencing and gene expression in maize
TS-048073 — In functional genomic experiments to support maize breeding programs, it is difficult to understand the function of an individual gene due to that gene’s interaction with other molecular features. Furthermore, while it is possible to target multiple genes in genomic experiments, it is not fr…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Xie, Wenshuang
  • Licensing Officer: Dahlman, Jason "Jay"

Isolation of an Ohio Porcine Epidemic Diarrhea Virus (PEDV) PC22A Strain in Cell Culture
TS-046905 — Porcine epidemic diarrhea virus (PEDV) has historically been an exotic disease to the U.S.. As of May, 2013, the virus made its way from China to the U.S.. This virus causes nearly 100% mortality in piglets and ranges from 80-90% morbidity. There is currently no PEDV vaccine in production. This inve…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda; Oka, Tomoichiro; Wang, Qiuhong
  • Licensing Officer: Dahlman, Jason "Jay"

Next-generation method for flow estimation and geospatial mapping of agricultural particulates
TS-046029 — Next-generation agricultural sensor technology enables precise, data-based decision-making to be implemented at the farm level. Field operations data such as granular fertilizer application rates are useful to the producer, because optimization of nutrient supplementation increases use efficiency …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Colley III, Richard; Fulton, John
  • Licensing Officer: Dahlman, Jason "Jay"

Compact Cas9-based transcriptional regulators for in vivo gene regulation
TS-045681 — Cas9-derived constructs can be used to modulate gene expression, but physical limitations restrict the application of this technique. Researchers at The Ohio State University have overcome this obstacle by engineering new Cas9-derived transcription factors.
CRISPR/Cas9 systems have revolutionized the field of programmable DNA technology. Recently, a version of the Cas9 protein with a deactivated nuclease domain called “dCas9” was developed. Without this domain, dCas9’s range of activity is limited to recognizing and binding sequence…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Dahlman, Jason "Jay"

mRNA sequence engineering and uses thereof
TS-045448 — Maximized mRNA lifespan and translation for mRNA-based therapy applications.
Many diseases emerge from irregularities that occur during protein synthesis. While limited therapies exist to deliver mature proteins to compensate for these errors, protein therapy by direct protein delivery has limited efficiency. This is due to difficulty in controlling the volume of delivered…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zeng, Chunxi
  • Licensing Officer: Dahlman, Jason "Jay"

Improving immunotherapy with mRNA delivery
TS-045426 — The central mission of cancer immunotherapy treatments is to aid the immune system in detecting and degrading cancer cells. For twenty years, the use of monoclonal antibodies (mAbs) as anti-tumor drugs has been successful in managing cancer disease and increasing patient lifespan. These treatments…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Li, Wenqing; Zhang, Chengxiang
  • Licensing Officer: Dahlman, Jason "Jay"

Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"

Isolation of Porcine Epidemic Diarrhea Virus (PEDV) strain Iowa106
TS-044567 — Porcine epidemic diarrhea virus (PEDV) appeared in the US in 2013 and has spread rapidly throughout North America. The virus causes gastroenteric disease in adults and is fatal to nursing piglets, whose only protection from the disease is via passive immunity from their mother. Currently, most US …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Qiuhong; Oka, Tomoichiro; Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Antimicrobials to Control Campylobacter
TS-044474 — Campylobacter is a leading cause of foodborne disease in humans, affecting more than one million Americans each year. Campylobacteriosis is projected to remain one of the most-frequent causes of disease and death worldwide. Human infection primarily occurs by ingesting contaminated chicken, and tr…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Acuna, Ulyana Munoz; Antwi, Janet; Carcache de Blanco, Esperanza; Fuchs, James; Kumar, Anand; Nislow, Corey; Pascall, Melvin
  • Licensing Officer: Dahlman, Jason "Jay"

Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: Dahlman, Jason "Jay"

Translational Activators of the Glutamate Transporter EAAT2 to Treat Neurological and Psychiatric Diseases
TS-043938 — Small molecule technology with novel translational activation mechanism.
Glutamate is a major neurotransmitter in the mammalian central nervous system (CNS) and essential for normal brain function including cognition, memory, and learning. However, the extracellular concentration of glutamate must remain below excitotoxic levels (~ 1 μM) to avoid overstimulation of …
  • College: College of Medicine (COM)
  • Inventors: Lin, Chien-Liang; Hodgetts, Kevin
  • Licensing Officer: Dahlman, Jason "Jay"

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Dahlman, Jason "Jay"

FARM: Fertilizer Application Resource Monitor
TS-041592 — FARM is a real-time mobile application that uses precipitation forecasts to guide farmers in their use of fertilizer and pesticides.
Weather forecasting is a useful tool for farmers who need to decide how best to treat their crops. Applying fertilizer or pesticide to crops, just to have the rain wash it away, results in a waste of resources. Additionally, many areas such as Ohio have regulations for fertilizer and pesticide run…
  • College: Office of Academic Affairs
  • Inventors: Wilson, Aaron
  • Licensing Officer: Dahlman, Jason "Jay"

Methods of Pre-conditioning Patients for T-cell Therapy
TS-041497 — Recent advances in Chimeric Antigen Receptor (CAR) T-cell therapy have generated hope in treatment of diseases such as cancer and HIV/AIDS. Cytotoxic lymphodepletion preconditioning is a step included in most CAR T-cell therapies, where T-cells and “cytokine sink” cells are depleted to…
  • College: College of Veterinary Medicine
  • Inventors: Kim, Sanggu
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis
TS-040540 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

The OSU Soil Organic Matter Calculator
TS-040136 — The Ohio State University’s Soil Organic Matter Calculator is a program that can be used to calculate future organic soil quality, greenhouse gas emissions, nitrogen fertility over short- and long-term scenarios in rder to help farmers decide more sustainable methods of agriculture.
Farmers, scientists, educators, industries and other non-profit organizations are increasing in need of a simple way to make accurate models and simulations of the environmental impact of land management choices and practices. Various different group and organizations from a wide variety of indust…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Islam, Khandakar; Grigar, Jerry; Reeder, Randall; Shedekar, Vinayak
  • Licensing Officer: Dahlman, Jason "Jay"

The FoodImage Smartphone App
TS-040080 — FoodImage quantifies food waste in near real-time using images of food products and food waste captured by end users or consumers.
Americans throw away approximately 80 billion pounds of food per year. However, in a study conducted by The Ohio State University, 53% of respondents indicated that food waste is a problem. A potential method to reduce food waste and its negative affects would be to increase awareness of the probl…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Roe, Brian; Apolzan, John; Martin, Corby
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecule growth inhibitors of avian pathogenic E. coli (APEC) as a means to control APEC infections in poultry.
TS-039568 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Control of Salmonella in poultry using new generation small molecule growth inhibitors
TS-039567 — Small molecule compounds that can be used to inhibit Salmonella growth for safe and sustainable poultry production.
Non-typhoidal Salmonella are among the top five intestinal pathogens in the United States. Among foodborne illnesses, they are responsible for 11% of illnesses, 35% of those hospitalizations, and 28% deaths, with an estimated cost of $3.6 billion in 2014. Poultry is the most common source of wide-…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Miller, Sally; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Mucoadhesive Nanoparticle Entrapped Influenza Virus Vaccine Delivery System
TS-038882 — A mucoadhesive nonoparticle entrapped influenza virus vaccine delivery system for animals and humans.
As one of the top three swine respiratory health problems in the U.S., swine influenza virus (SIV) is a key concern for the industry. SIV – referred to as “swine flu” or “flu” – can be caused by a number of different swine influenza strains. SIV has evolved from…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Gourapura, Renukaradhya; Dhakal, Santosh; Renu, Sankar
  • Licensing Officer: Dahlman, Jason "Jay"

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