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Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
  • Licensing Officer: Willson, Christopher

Column-free Purification of Recombinant Proteins
TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat
  • Licensing Officer: Willson, Christopher

pH-sensitive inhibitor release system for corrosion protection
TS-062835 — Coatings are broadly used to protect metallic structures from corrosion. However, aggressive acidic and alkaline conditions can both develop locally on the coated metal surface due to corrosion, leading to the failure of the coated structure. Commonly used smart coatings use a timed release of spe…
  • College: College of Engineering (COE)
  • Inventors: Li, Chao; Frankel, Gerald "Jerry"; Guo, Xiaolei
  • Licensing Officer: Zinn, Ryan

Heteroatom doped Carbon Nanostructures for Electrocatalytic Chlorine and Bromine Production
TS-062692 — Chlorine is used in production of many products, such as many polymers like polyvinyl chloride, polyurethanes and chloroaromatics. It is also used extensively in pharmaceuticals, pesticides, fiber optics, hypochlorite bleaches, and other commodities. However, the current method of producing chlori…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Jain, Deeksha; Mamtani, Kuldeep
  • Licensing Officer: Zinn, Ryan

Novel Efficient Butanol Production without CO2 Emission
TS-062607 — Chemicals and fuels from renewable resources have gained global interest due to environmental issues, climate change, oil price and supply volatility, and decreasing nonrenewable fossil fuel sources. Butanol is a biofuel alternative that can provide a higher heating value, lower volatility, polarity…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Willson, Christopher

Method and device for determining virus titer by surface enhanced Raman scattering
TS-062346 — The ability to rapidly identify and determine virus titer is of utmost importance in numerous biomedical applications, ranging from gene editing to pharmaceutical and vaccine development. In the context of lentiviruses, which are widely used for cell reprogramming in immunotherapies, knowing the e…
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Morder, Courtney
  • Licensing Officer: Willson, Christopher

Dual ligand systems for cross-coupling of challenging C(sp2) and C(sp3) electrophiles.
TS-059018 — An unusual series of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings of previously incompatible substrate combinations.
Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are desirable methodologies for C–C bond formation but are limited to specific substrate classes. Couplings of widely-available electrophiles such as aryl chlorides or triflates are currently unknown with any alkyl b…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Hamby, Taylor
  • Licensing Officer: Willson, Christopher

Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-058577 — Novel, transition metal-free catalysts capable of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Hodge, Kelsey
  • Licensing Officer: Willson, Christopher

Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-048726 — Novel, transition metal-free catalysts capable of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Hodge, Kelsey
  • Licensing Officer: Willson, Christopher

Activity Enhancement of Perovskite-Type Cathode Material
TS-044391 — A new ammonia production technology using an oxygen ion conductive solid oxide electrolyte cell (SOEC) reactor and a novel cathode material.
Ammonia is utilized in a variety of industries with 80% of produced ammonia used for fertilizer production. Most commercial ammonia is produced using the Haber-Bosch (HB) process, which requires high temperatures and pressures, resulting in high operational/production costs. The process typically us…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Deka, Dhruba Jyoti; Gunduz, Seval
  • Licensing Officer: Zinn, Ryan

Development of a Single Component Methacrylate Adhesive Formulation
TS-042066 — A novel hybrid adhesive that combines the non-toxic, high strength properties of methacrylate adhesives with the bonding characteristics of polyurethanes
Despite the utility of methacrylate adhesive chemistry, applications have been limited to industrial and biomedical use cases. This is due to the curing mechanism, which is initiated by either heat, light or a two-component redox system. This invention describes two strategies to create a single-c…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Schricker, Scott
  • Licensing Officer: Willson, Christopher

Method for Connectorizing Superconducting NbTi Coaxial Cables
TS-040418 — A fast and inexpensive electroplating technique for producing a connector attachment matching the structural and electrical properties of standard coaxial cables for cryogenic applications.
Experiments performed at cryogenic temperatures much below the 4.2 K of liquid helium frequently require superconducting coaxial cables to efficiently transmit high frequency signals while minimizing heat transfer to the experiment’s cold stage. These cables are most often made of niobium-ti…
  • College: College of Arts & Sciences
  • Inventors: DeBry, Kyle; Lafyatis, Gregory
  • Licensing Officer: Willson, Christopher

Iron Oxide Composites with Low Concentration of Aliovalent Dopants As Oxygen Carrier Materials for Sustainable Redox Combustion and Gasification Reactions in Chemical Looping Reactor Systems
TS-038513 — Addition of low concentration aliovalent transition metal dopants substantially improves particle performance in chemical loopiong systems
Cyclic systems are required for energy conversion systems. In the clean energy industry, chemical looping offers promise for carbon dioxide capture from fossil energy. Transition metal oxides such as iron oxide, nickel oxide, and copper oxide have been singled out as the desired active oxygen carr…
  • College: College of Engineering (COE)
  • Inventors: Fan, Liang-Shih; Cheng, Zhuo; Chung, Cheng; Guo, Mengqing "MENGQING"; Qin, Lang
  • Licensing Officer: Ashouripashaki, Mandana

Development of Non-Foaming High Strength, Single Component Methacrylate/Polyurethane Adhesive
TS-037956 — A single component, moisture-cured methacrylate/polyurethane hybrid adhesive that combines the non-toxic, high strength properties of methacrylate adhesives with the bonding characteristics of polyurethanes
Methacrylate adhesives are strong and can be used on similar or dissimilar materials, such as plastic, metal, composites, and ceramic. They have excellent peel strength, resist abrasion, and stand up to a fair range of temperatures. They also require little preparation of the surfaces to be bonded…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Bewick, Nicholas; Schricker, Scott
  • Licensing Officer: Willson, Christopher

N-Proanol and Propionic Acid Producing Propionibacteria
TS-037515 — New method of producing n-propanol and propionic acid using a metabolically engineered propionibacteria.
Propionibacteria are well-known for their various industrial applications including the manufacturing of Swiss cheese, vitamin B12, and propionic acid. However, not much is known about their genetics, and few studies have been conducted utilizing them for metabolic engineering, mostly in vitamin B…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Ammar, Ehab
  • Licensing Officer: Willson, Christopher

Low temperature oxidation of carbon monoxide on Co/ZrO2 catalysts
TS-015047 — Catalytic conversion of carbon monoxide to carbon dioxide.
Air pollution is a serious global problem and has received a great deal of attention over the last few decades. Industrial plants and automobiles release a significant amount of pollution into the atmosphere, principally in the form of unburned or partially burned fossil fuels, carbon monoxide, ni…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Holmgreen, Erik; Yung, Matthew
  • Licensing Officer: Zinn, Ryan

Synthesis of Hydrogen Gas
TS-014807 — Production of Hydrogen gas using economical and environmentally friendly catalysts.
Stable and reusable catalysts improve the efficiency of industrial scale material production. However, hexavalent Chromium (VI) and other common catalysts are known to cause various health effects. Furthermore, there are substantial risks associated with greater concentrations of chromium in the w…
  • College: College of Engineering (COE)
  • Inventors: Ozkan, Umit; Natesakhawat, Sittichai; Wang, Xueqin; Zhang, Lingzhi
  • Licensing Officer: Zinn, Ryan

High Surface Area Catalysts for Fuel Cells
TS-014755 — A high performance and durable reductive catalyst for polymer and metal-air fuel cells
Fuel cells offer a cleaner, more-efficient alternative to gasoline and other fossil fuels, and have the potential to revolutionize the way the nation is powered. Fuel cells operate in a similar fashion to conventional batteries, but fuel cells can be continually supplied with a fresh feed of fuel,…
  • College: College of Arts & Sciences
  • Inventors: Co, Anne; Coleman, Eric
  • Licensing Officer: Randhawa, Davinder

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