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Automated Plant DNA Extraction for Portable Genomic Sequencing
TS-063963 — The Need In the dynamic realm of space exploration, the imperative to sustain life during extended missions places a critical demand on understanding the impact of spaceflight on plant growth. Traditional DNA sequencing methods employed by NASA fall short when dealing with plant material, necessita…
  • College: College of Engineering (COE)
  • Inventors: Brozovich, Cassidy; Ling, Peter; Tkach, Chris
  • Licensing Officer: Randhawa, Davinder

A modified intein for temperature sensitive applications
TS-063697 — Controlled Protein Release Over a Broad Range of Temperatures
The Need: In the biotechnology field, the demand for efficient protein purification methods and innovative drug delivery solutions is ever-growing. Researchers and companies require technologies that can streamline the purification process, ensuring high yields and purity, while offering versatile …
  • College: College of Engineering (COE)
  • Inventors: Wood, David; Coolbaugh, Michael; Stimple, Samuel "Sam"; Yuan, Hongyu
  • Licensing Officer: Dahlman, Jason "Jay"

Post synthetic incorporation of Ti into zeolite Beta via defect sites originating from methyl-silanes and its impacts on epoxidation and reduction reactions
TS-062968 — A novel method of creating catalytic material containing paired Lewis acids in combination with alkyl-metal precursors for improving the production of materials used in agricultural, chemical, and other commercial/industrial applications/processes.
More efficient techniques to create catalytic material are required to enable higher efficiencies and other performance improvements when used for manufacturing of specialty chemicals and other compounds. The conventional methods whereby Lewis acids play a role in catalysis has some key limitation…
  • College: College of Engineering (COE)
  • Inventors: Brunelli, Nicholas "Nick"; Spanos, Alex
  • Licensing Officer: Randhawa, Davinder

Tuning the nature of the catalytic site through synthesizing Lewis acid zeolite Beta with alkyl-Sn precursors
TS-062967 — Novel method capable of using alkyl tin compounds to generate Lewis acid zeolite Sn-Beta.
Conventional approaches used in chemical processes such as synthesis for production of materials involve formation of catalytic sites within the process framework. Current methods used for catalytic site creation tend to be long and result in increased production costs. This is partially due to re…
  • College: College of Engineering (COE)
  • Inventors: Brunelli, Nicholas "Nick"; Spanos, Alexander
  • Licensing Officer: Randhawa, Davinder

Grass Surrogate
TS-062844 — Road departure is a serious threat to vehicle safety and can result in fatal accidents. To prevent road departure, some vehicles are equipped with a road departure mitigation system that can detect when a vehicle is about to leave the road and take corrective actions. However, there is a need for …
  • College: College of Engineering (COE)
  • Inventors: Chen, Chi-Chih
  • Licensing Officer: Zinn, Ryan

Surrogates for Concrete Dividers
TS-062834 — Road departure can be extremely dangerous for vehicles. Some vehicles are equipped with road departure mitigation systems to prevent this from happening. However, testing these systems can be difficult and costly, as it involves crashing vehicles into roadside objects. The concrete divider surr…
  • College: College of Engineering (COE)
  • Inventors: Chen, Chi-Chih; Chen, Yaobin; Chien, Stanley; Lin, Jun; Sherony, Rini; Yi, Qiang
  • Licensing Officer: Zinn, Ryan

Surrogates for Metal Guardrails
TS-062797
Road departures remain a significant source of traffic accidents. Tools for limiting road departures are needed to reduce accidents and improve safe driving conditions. The Ohio State University researcher Dr. Chi-Chih Chen, along with a team of researchers, has developed a novel metal guardrai…
  • College: College of Engineering (COE)
  • Inventors: Chen, Chi-Chih; Chen, Yaobin; Chien, Stanley; Lin, Jun; Sherony, Rini
  • Licensing Officer: Zinn, Ryan

Utilization of Interconnections in Electronic Circuits as Magnetohydrodynamic Pumps for Liquid Metalbased Cooling
TS-062494 — A novel magnetohydrodynamic (MHD) pump-based thermal management system design where integration of the cooling apparatus using electronic circuit interconnections achieves improved thermal management at a lower cost.
Newer applications incorporating high-power electronics designs face greater thermal management challenges and impact systemic stability and reliability. Enhanced cooling techniques in these complex electronic systems rely on liquid cooling instead of air cooling. However, liquid cooling approache…
  • College: College of Engineering (COE)
  • Inventors: Wang, Jin; Fan, Junchong
  • Licensing Officer: Ashouripashaki, Mandana

"Flexible biomarker biofluid cell array for 2D/3D mapping of biomarker concentration levels"
TS-062483 — Measurement/detection of analytes (e.g., biomarkers) in different environments (e.g., biofluids/organs) is typically performed using a biosensor. Available bio-integrated sensors do not provide the capability to map biomarker concentrations, require a power source to function, use a limited number of electrodes, and normally can only measure a specific type of biofluid but not others. The use of glutamate mapping technology (radioactive or fluorescent ligand bound to a glutamate receptor) has been evaluated and found to require bulky/expensive medical equipment, a power source for measurement, cannot be miniaturized or integrated into a bio tissue, and require patients to be stationary during measurement.
The Need To address concerns and limitations with current biomarker detection/ measurement technologies, an alternative, cost-effective, efficient biosensing system/device capable of 2D/3D mapping the concentrations of various biomarkers in different bio environments is required. The Technology …
  • College: College of Engineering (COE)
  • Inventors: Li, Jinghua; Liu, Tzu Li; Nithianandam, Prasad
  • Licensing Officer: Ashouripashaki, Mandana

Low-Cost, Multiplexed Microfluidic Force Spectroscopy on-a-Chip
TS-057780 — A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.
Development of several force spectroscopy strategies have enabled characterization of various types of molecular binding interactions with applications in biophysics, molecular biology and medicine. Despite various efforts to decrease the cost of force spectroscopy, full characterization of a mole…
  • College: College of Engineering (COE)
  • Inventors: Akbari, Ehsan; Castro, Carlos; Shahhosseini, Melika; Song, Jonathan "Jon"
  • Licensing Officer: He, Panqing

Oxygen Sensing Nanofibers
TS-014967 — Nanofibers designed to quantify the oxygen content of a local environment for cell cultures and tissue-based applications such as a wearable technology wirelessly integrated into an electronic device used to estimate the efficiency of an individual's oxygen consumption.
Measurements of growth and activity of living cells are advantageous in a wide array of applications. Such measurements can be used to track tissue regeneration, phenotypic change, localized hypoxia, the testing and development of antibiotics and much more (Maria Strianese et al., Scott Lynn et al…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Xue, Ruipeng
  • Licensing Officer: Zinn, Ryan

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