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DAT-CI knock-in mouse model carrying a modified dopamine transporter that maintains the transport function but resistant to cocaine inhibition and thus showing no rewarding cocaine effects
TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.
Cocaine abuse has been an issue in the United States since the late 1980s. The highly addictive qualities along with the low cost ruined people’s lives and destroyed communities. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an overdose. Therefore, th…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Schultz, Teri

NET-CI knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that maintains the transport function and makes the transporter protein resistant to cocaine and antidepressants
TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.
Cocaine abuse has been an issue in the United States since the late 1980s. Furthermore, antidepressants also quite dangerous, with nearly 14% of users (who have bipolar disorder) experiencing dependence. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an over…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Schultz, Teri

Mobile Application to Reduce the Risk of Narcotics Abuse Through Patient and Provider Empowerment
TS-041604 — This mobile application for pain management provides simple tools for patients, providers and researchers to use during clinical trials. The app not only tracks the efficacy of each patient's treatment, it can provide additional information to supplement and support the needs of the clinical trial.
The recent opioid epidemic has devastated American cities and kills 91 Americans per day. 80% of these addicts start with prescription pain killers. Preventative strategies to lower opioid use must be developed as most state adopted regulatory measures have failed. The development of such preventa…
  • College: College of Medicine (COM)
  • Inventors: Chandawarkar, Rajiv; Capek, Allison
  • Licensing Officer: Taysavang, Panya

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