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Instant Diagnostics, Anywhere
TS-070543 — A Platform for High-Throughput Biomarker Detection that is portable, fast, and requires minimal sample
The Need The diagnostics market is under increasing pressure to deliver faster, more reliable, and less invasive solutions, driven by growing global health challenges. Current technologies face critical limitations, including large sample requirements, labor-intensive workflows, and reliance on exp…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Seth, Ayesha; Zerrudo, Stephanee
  • Licensing Officer: Panic, Ana

Wearable Muscle Atrophy Sensor
TS-070305 — The Need Muscle atrophy significantly impacts quality of life in patients with critical illness, chronic disease, aging, and even spaceflight. Current gold-standard diagnostic tools such as MRI, CT, and ultrasound are expensive, operator-dependent, and impractical for routine or home-based monitorin…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Rice, Allyanna
  • Licensing Officer: Randhawa, Davinder

Method to Determine Tremor Frequency from Deep Brain Stimulation Signals
TS-070304 — The Need Current clinical methods for assessing tremor severity in patients with Parkinson’s disease and other movement disorders rely heavily on subjective, qualitative observations, such as evaluating hand-drawn spirals or observing motor tasks. These approaches lack precision, are difficult…
  • College: College of Engineering (COE)
  • Inventors: Khan, Furrukh; Dalm, Brian; Novikov, David; Thomas, Evan; Zhao, Jessie
  • Licensing Officer: Randhawa, Davinder

Aerobiology Chamber for Pilot-scale Studies
TS-070103 — The Need Aerobiology chambers on the market today face several challenges, particularly in studying biohazardous aerosols and testing anti-bioaerosol agents. Large, room-sized chambers, while capable of mimicking indoor environments, are cumbersome to operate, require extensive decontamination, an…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Yousef, Ahmed; Ali, Mohamed; Kasler, David; Kwiek, Jesse; Sastry, Sudhir
  • Licensing Officer: Panic, Ana

Motion-Guided Deep Image Prior (M-DIP) for Dynamic Image Reconstruction in Cardiovascular MRI
TS-069527 — The Need Cardiovascular MRI (CMR) data acquisition is often time-consuming and relies on complex reconstruction methods that do not fully exploit the spatial and temporal structure of CMR data. There is a need for a more efficient, unsupervised approach that can accelerate CMR imaging while maintai…
  • College: College of Engineering (COE)
  • Inventors: Ahmad, Rizwan; Chen, Chong; Sultan, Muhammad
  • Licensing Officer: Randhawa, Davinder

A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Panic, Ana

Noninvasive Rapid Radiation Exposure Assay
TS-068290 — The Need Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require invasive procedures and may not detect exposure at lower dose ranges. …
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Jacob, Naduparambil; Morder, Courtney; Witte, Spencer
  • Licensing Officer: Panic, Ana

RAFT Agents for Controlled Radical Polymerization of Biofunctionalized Polymeric Materials
TS-068081 — These RAFT agents enable synthesis of novel polymer materials with enhanced biocompatibility and tailored functionality, suited for a wide range of biomedical applications.
Background The growing demand for biofunctionalized polymer materials in fields such as drug delivery and diagnostics requires precise control over polymer properties. However, current reagents for Reversible Addition Fragmentation chain Transfer (RAFT) polymerization struggle with achieving the ne…
  • College: College of Arts & Sciences
  • Inventors: Kulkarni, Anuja; Watkins, Davita
  • Licensing Officer: Panic, Ana

Wearable Coils for Monitoring Human Body Kinematics
TS-067943 — Monitoring human physiological functions and performance during real-time activities is becoming increasingly popular in sporting and healthcare environments. Many studies now suggest that the quantitative evaluation of kinetic parameters, joint range of motion, heart rate, and breathing rate can be…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Mishra, Vigyanshu
  • Licensing Officer: Randhawa, Davinder

Non-Contact Magnetocardiography for Measuring Cognitive Workload
TS-067810 — Work environments and other brain-intensive activities impose high demands on the cognitive and cerebral resources required to process vast amounts of information. This high demand can expose individuals to cognitive overload, which can be dangerous for their health and lead to errors and accidents.…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Zhu, Keren
  • Licensing Officer: Randhawa, Davinder

Neonatal Blood Vessel Locator for Vascular Access Procedures
TS-067796 — A handheld device for identifying preterm blood vessels in neonatal ICU.
Over 300,000 preterm births in the United States occur annually, representing 10.5% of all live births. Most preterm births occur spontaneously, but some result from medical conditions like infections or pregnancy complications requiring early labor induction or cesarean delivery. Common causes of p…
  • College: College of Engineering (COE)
  • Inventors: Metzler, Sandra; Bresolin, Alejandro; Crawford, Mackenzie; Fernandes, Siddharth; Hardin, Rene; Patel, Aarti; Richards, Hannah; Trainor, Dylan
  • Licensing Officer: Zinn, Ryan

Optimal and Pure Leaf Classification Trees for Machine Learning (ML) Decision-Making
TS-067550 — A method to improve the performance and accuracy of ML-based decision trees.
Decision trees are popular machine learning (ML) methods used in classification and regression problems, and they have numerous applications in the real world. Various industries use decision trees to help decide strategies, investments, and operations. In addition, they are used in healthcare to he…
  • College: College of Engineering (COE)
  • Inventors: Allen, Theodore; Arrey, Evelyn; Booth, Matthew; Liu, Enhao; Mashayekhi, Medhi
  • Licensing Officer: Zinn, Ryan

Endoscopic additive manufacturing of conductors and wireless implants
TS-067045 — The Need Wireless implants with integrated antennas are highly desirable for diagnostic, therapeutic, and monitoring applications due to their ability to communicate directly with external devices. However, the need for major surgical incisions to implant these devices poses significant risks, incl…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Dontha, Balaji; Hoelzle, David; Li, Jinghua; Moulod, Mohammad
  • Licensing Officer: Randhawa, Davinder

Dust Analysis: A Novel Approach to Monitoring Viral Spread
TS-066962 — The Need Viral disease surveillance (e.g. influenza, SARS-CoV-2) in high-risk settings faces several challenges, such as asymptomatic carriers, incomplete reporting, resource limitations, and delayed diagnosis of traditional swab test methods. These challenges could allow a virus to silently spread…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Faith, Seth; Hull, Natalie; Nastasi, Nick; Renninger, Nicole
  • Licensing Officer: Ashouripashaki, Mandana

Color Correction System for Accurate Colorimetric Smartphone Measurements
TS-066957 — The Need Colorimetric tests and remote image analysis are used in a wide range of industrial and medical applications. Digital image-based measurements made with smartphones are a promising platform to quantify colors at low cost, but suffer from inconsistency and errors caused by lens quality, sen…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Panescu, Jenny; Qin, Rongjun; Song, Shuang; Zhang, Guixiang
  • Licensing Officer: Ashouripashaki, Mandana

Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 — Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
  • College: College of Medicine (COM)
  • Inventors: Al Tarawneh, Rawan
  • Licensing Officer: Willson, Christopher

Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-066751 — In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Traditional methods face challenges with membrane impermeability and degradation of therapeutic compounds, limiting th…
  • College: College of Arts & Sciences
  • Inventors: Pei, Dehua
  • Licensing Officer: Dahlman, Jason "Jay"

Innovative Small Molecule Inhibitors for Effective Treatment and Prevention of Coronavirus Infections
TS-066750 — The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global health and economies. Despite vaccine efforts, issues such as vaccine hesitancy, delays in distribution, and emerging variants have highlighted the need for effective therapeutic interventions. These i…
  • College: College of Veterinary Medicine
  • Inventors: Sharma, Amit; Li, Pui-Kai "Tom"; Xing, Enming
  • Licensing Officer: Willson, Christopher

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