MicroRNA profile predicts colon cancer prognosis
TS-065453 — The Need:
Colon cancer remains one of the most prevalent and lethal forms of cancer worldwide. Timely and accurate diagnosis is critical for effective treatment and improved patient outcomes. Current diagnostic methods often lack the precision and sensitivity needed for early detection and prognosi…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo
- Licensing Officer: Schultz, Teri
Scalable Nanoparticle Synthesis for Precision Applications
TS-064181 —
In the rapidly evolving landscape of nanotechnology, there exists a critical demand for scalable and efficient methods of producing nanoparticles. Current approaches, often confined to small-scale batches, hinder the widespread implementation of nanomaterials in diverse fields such as medicine, bi…
- College: College of Engineering (COE)
- Inventors: Winter, Jessica; Ruan, Gang
- Licensing Officer: Dahlman, Jason "Jay"
Unveiling Biochemically Responsive MR Probes for Precision Beyond Limits
TS-064179 —
In the realm of medical diagnostics, the need for precise and non-invasive detection of molecular-level pathology has been a longstanding challenge. Traditional imaging techniques often fall short in providing detailed insights into biological processes at this scale. To address this gap, there is…
- College: College of Arts & Sciences
- Inventors: Shafaat, Hannah "Hannah"
- Licensing Officer: Dahlman, Jason "Jay"
A new diagnostic assay for classic galactosemia
TS-064133 — Classic galactosemia is a genetic condition that can lead to life-threatening complications, including feeding problems, failure to thrive, liver damage, bleeding, and sepsis. If a lactose-restricted diet is provided during the first ten days of life, the neonatal symptoms quickly resolve and reduce…
- College: College of Arts & Sciences
- Inventors: Gopalan, Venkat; Bashian, Eleanor; Thirugnanasambantham, Pankajavalli
- Licensing Officer: Panic, Ana
Enhancing Surgical Precision with Anti-TAG-72 Imaging Agents
TS-062548 — The Need: Enhancing Surgical Precision with Anti-TAG-72 Imaging Agents
Colorectal carcinoma is a significant medical challenge, with a high incidence rate in the USA. Current surgical approaches, along with external imaging technologies, have limitations in accurately detecting cancerous tissues, l…
- College: College of Medicine (COM)
- Inventors: Gong, Li; Tweedle, Michael
- Licensing Officer: Willson, Christopher
Functional "fingerloop" DNA antisense motifs for nucleic acid targeting and detection technologies
TS-062547 — The Need: The field of molecular biology and genetic engineering faces challenges in achieving precise and accurate detection and amplification of target nucleic acid sequences. Traditional hybridization technologies suffer from the issue of mismatched targets, leading to reduced specificity and rel…
- College: College of Arts & Sciences
- Inventors: Lease, Richard
- Licensing Officer: Dahlman, Jason "Jay"
Addressing the Challenges in Cancer Imaging
TS-062545 — The Need: Addressing the Challenges in Cancer Imaging
Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
- College: College of Arts & Sciences
- Inventors: Magliery, Thomas; Long, Nicholas; Sullivan, Brandon
- Licensing Officer: Dahlman, Jason "Jay"
Addressing the Challenges in Cancer Imaging
TS-062544 — The Need: Addressing the Challenges in Cancer Imaging
Cancer continues to be a major cause of global mortality, with over 10% of all deaths attributed to this devastating disease. Despite significant advancements in cancer research, there remains a critical need to enhance current techniques for pr…
- College: College of Arts & Sciences
- Inventors: Magliery, Thomas; Allen, Heather; Alten, Edward; Hitchcock, Charles; Long, Nicholas; Martin, Edward; Sullivan, Brandon
- Licensing Officer: Dahlman, Jason "Jay"
MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers
TS-062318 — The Need
Cancer is a significant health problem and a leading cause of death in developed countries. Solid cancers, including prostate, breast, lung, stomach, colon, and pancreatic cancers, pose particularly challenging diagnostic and treatment obstacles. Early detection of these cancers is crucial…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo; Calin, George; Volinia, Stefano
- Licensing Officer: Willson, Christopher
Diagnostics and Prognostics of Prostate Cancer
TS-062299 — The Need: Addressing Prostate Cancer Diagnostics and Therapeutics
Prostate cancer remains a significant challenge in medical diagnosis and treatment, requiring advancements in diagnostics, therapeutics, and prognostics. Current approaches fall short in providing accurate and effective solutions, le…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo
- Licensing Officer: Willson, Christopher
MicroRNA signatures in human ovarian cancer
TS-062298 — The Need:
Ovarian cancer remains a significant challenge in the field of medicine, with late-stage diagnosis and limited effective treatments contributing to high mortality rates. The need for improved diagnostic tools and targeted therapies is evident to address this aggressive disease. Convention…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo
- Licensing Officer: Willson, Christopher
Composition and Methods for Lung Cancer Diagnosis and Treatment
TS-062296 — The Need: Advancing Lung Cancer Detection and Treatment
Lung cancer continues to be a global health concern, accounting for the highest number of cancer-related deaths worldwide. In the United States, it is the leading cause of cancer mortality for both men and women, with a disheartening five-year…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo; Calin, George
- Licensing Officer: Willson, Christopher
Composition and Methods for Breast Cancer Diagnosis and Treatment
TS-062295 — The Need:
Breast cancer continues to be a significant health challenge, affecting a large number of women worldwide and remaining the second leading cause of cancer-related deaths among women in the United States. Despite advancements in detection and treatment, there is no universally successful m…
- College: College of Medicine (COM)
- Inventors: Croce, Carlo; Calin, George
- Licensing Officer: Willson, Christopher
Diagnostic for Early Detection of Heart Damage
TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.
Despite significant medical advances and technologies, cardiovascular disease remains the number one cause of death in the United States, irrespective of gender or race, resulting in more than 600,000 annual deaths. Additionally, while cancer survivorship has increased significantly, the number one …
- College: College of Medicine (COM)
- Inventors: Smith, Sakima; Dib, Patrick; McElroy, Craig
- Licensing Officer: Schultz, Teri
SARS-CoV-2 Diagnostic Assay with Sensors of Immune Activation
TS-050296 — A sequencing-based diagnostic assay for SARS-CoV-2 with sensors of immune activation and the viral microbiota.
Diagnosis of SARS-CoV-2 infection, which is responsible for COVID-19 disease, is typically performed by molecular analysis of upper respiratory sampling (e.g. nasal swab). Transcriptional-mediated amplification (TMA) and quantitative (real-time) polymerase chain reaction (qPCR) using one or more v…
- College: College of Medicine (COM)
- Inventors: Jones, Daniel; Avenarius, Matthew; Tu, Huolin
- Licensing Officer: Schworer, Adam
DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
- College: College of Engineering (COE)
- Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
- Licensing Officer: Willson, Christopher
Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
- College: College of Arts & Sciences
- Inventors: Badu-Tawiah, Abraham; Damon, Deidre
- Licensing Officer: Panic, Ana
miRNA-based Predictive Model for Biochemical Failure Following Post-Prostatectomy Salvage Radiation Therapy
TS-037521 — A method to use MiRNA to predict the likelihood of biochemical failure after radiation surgery.
The Need
Prostate cancer is one of the most common cancers worldwide, but current treatments can sometimes lead to complications. For example, radical prostatectomy is widely used for men in the early stages of prostate cancer, but long-term data shows that 30-40% of these patients experience bioch…
- College: College of Medicine (COM)
- Inventors: Chakravarti, Arnab; Bell, Erica
- Licensing Officer: Schworer, Adam
Fingerloop sRNA Nanotechnology for Metabolic Engineering and Synthetic Biology
TS-037383 — Functional "fingerloop" RNA antisense motifs for metabolic engineering and RNA nanotechnology applications.
The Need
Synthetic biology holds tremendous promise to revolutionize how numerous products are made. For example, microorganisms can be harnessed to produce useful products such as biofuels, chemicals, therapeutics, fragrances, and antibodies, just to name a few examples. However, metabolic enginee…
- College: College of Engineering (COE)
- Inventors: Lease, Richard; Lahiry, Ashwin; Stimple, Samuel "Sam"; Wood, David
- Licensing Officer: Dahlman, Jason "Jay"
Circulating Microvesicles Biomarkers and Molecular Targets in Disease
TS-035400 — Discovery of microvesicles containing microRNA from myeloid cells that can serve as biomarkers and molecular targets
The Need: The advancement of microRNA (miRNA) research has uncovered their crucial role in regulating gene expression, cell function, and differentiation. These small non-coding RNAs are present in animals and plants and have been associated with various diseases, including cancer and inflammatory d…
- College: College of Medicine (COM)
- Inventors: Marsh, Clay; Ismail, Noura; Piper, Melissa
- Licensing Officer: Willson, Christopher
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