# of Displayed Technologies: 11 / 11

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Diagnostic for Early Detection of Heart Damage
TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.
Despite significant medical advances and technologies, cardiovascular disease remains the number one cause of death in the United States, irrespective of gender or race, resulting in more than 600,000 annual deaths. Additionally, while cancer survivorship has increased significantly, the number one …
  • College: College of Medicine (COM)
  • Inventors: Smith, Sakima; Dib, Patrick; McElroy, Craig
  • Licensing Officer: Csatary, Erika

Metabolite-Based Diagnostics for Joint Infection
TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.
Pseudomonas aeruginosa, a biofilm-producing pathogenic bacterium, exhibits resistance to many antibiotics. This leads to acute and chronic joint infections that are difficult to treat. Accordingly, a critical need exists for accurate biofilm diagnosis, prevention, and treatment. While culture-free…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Bruschweiler, Rafael; Leggett, Abigail
  • Licensing Officer: Csatary, Erika

SARS-CoV-2 Diagnostic Assay with Sensors of Immune Activation
TS-050296 — A sequencing-based diagnostic assay for SARS-CoV-2 with sensors of immune activation and the viral microbiota.
Diagnosis of SARS-CoV-2 infection, which is responsible for COVID-19 disease, is typically performed by molecular analysis of upper respiratory sampling (e.g. nasal swab). Transcriptional-mediated amplification (TMA) and quantitative (real-time) polymerase chain reaction (qPCR) using one or more v…
  • College: College of Medicine (COM)
  • Inventors: Jones, Daniel; Avenarius, Matthew; Tu, Huolin
  • Licensing Officer: Schworer, Adam

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Willson, Christopher

Automated Detection of Tumor Budding in Colorectal Cancer
TS-039267 — A non-invasive and automated tumor budding image analysis system for colorectal cancer. This program can detect tumor buds in traditional H&E stained sections without the need for manual assessment.
Colorectal cancer is the third most commonly diagnosed cancer in the United States. With a survival rate of less than 65%, early detection and treatment are key factors in survival. Tumor budding, associated with higher tumor stage, lymph node metastasis, and decreased disease-free survival, has e…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Ahmad Fauzi, Mohammad Faizal; Chen, Wei "Wei"; Frankel, Wendy
  • Licensing Officer: Hampton, Andrew

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Damon, Deidre
  • Licensing Officer: Willson, Christopher

At-Home Digital Platform for Scoring Skin Disease
TS-038429 — An automated image analysis system for the recognition and quantification of skin disease
Acne and rosacea are skin diseases that affect around 85% of individuals, the former being the most common skin condition afflicting up to 50 million people. There is no gold standard for evaluation of these skin diseases, and their treatment efficacy is generally determined according to a poorly …
  • College: College of Medicine (COM)
  • Inventors: Kaffenberger, Benjamin; Gurcan, Metin
  • Licensing Officer: He, Panqing

Cancer Cell Motility Monitoring Device
TS-038384 — A novel device for monitoring cancer cell motility in real time using standard microscopy.
The Need Numerous cancer cells are capable of migration, resulting in metastasis of distinct organs and tissues from where the cancer first arose. Migrating cancer cells are known to directionally respond to applied electric fields, a phenomenon called electrotaxis, as well as topological cues prov…
  • College: College of Engineering (COE)
  • Inventors: Garg, Ayush; Bushman, Sarah; Ferree, Jessica; Jones, Travis; Song, Jonathan; Subramaniam, Vishwanath
  • Licensing Officer: He, Panqing

RNA Sequencing Assay to Detect Gene Fusion Mutations that Occur in Multiple Cancer Types
TS-038065 — OSU­-SpARKFUSE is an RNA sequencing assay that detects known and novel gene fusion mutations in multiple cancer types.
Chromosomal rearrangements, leading to the juxtaposition of two unrelated genes and thus creating a chimeric mRNA transcript and protein ("gene fusions"), are important drivers of abnormal cell growth in cancers. Although gene fusions have a well-established role in hematologic malignanc…
  • College: College of Medicine (COM)
  • Inventors: Roychowdhury, Sameek
  • Licensing Officer: Schworer, Adam

Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
  • College: College of Arts & Sciences
  • Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
  • Licensing Officer: Willson, Christopher

Fingerloop sRNA Nanotechnology for Metabolic Engineering and Synthetic Biology
TS-037383 — Functional "fingerloop" RNA antisense motifs for metabolic engineering and RNA nanotechnology applications.
The Need Synthetic biology holds tremendous promise to revolutionize how numerous products are made. For example, microorganisms can be harnessed to produce useful products such as biofuels, chemicals, therapeutics, fragrances, and antibodies, just to name a few examples. However, metabolic enginee…
  • College: College of Engineering (COE)
  • Inventors: Lease, Richard; Lahiry, Ashwin; Stimple, Samuel "Sam"; Wood, David
  • Licensing Officer: Willson, Christopher

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