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A Novel African Swine Fever Vaccine
TS-062364 — The Need: Addressing the Threat of African Swine Fever Virus (ASF) African swine fever (ASF) presents a severe commercial burden given the highly contagious and deadly nature of the viral disease. With no existing treatment or vaccine available, ASF outbreaks have devastated domestic and feral pig …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Kenney, Scott; Gourapura, Renukaradhya
  • Licensing Officer: Dahlman, Jason "Jay"

Novel Antimicrobial peptides effective against avian pathogenic Escherichia coli (APEC) and Salmonella
TS-062229 — The Need: Microbial infections, particularly those caused by antibiotic-resistant pathogens like APEC and Salmonella, pose a significant commercial and health challenge. The demand for effective and innovative bioactive peptides capable of inhibiting these pathogens is escalating. Biotechnology comp…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Closs, Gary; FNU, Dhanashree; Kathayat, Dipak
  • Licensing Officer: Dahlman, Jason "Jay"

Nanoparticle Vaccine to combat Necrotic enteritis in poultry
TS-062219 — The Need: Addressing the Global Threat of Necrotic Enteritis in Poultry Necrotic enteritis (NE) poses a significant commercial challenge to the poultry industry, with estimated annual costs reaching up to 5-6 billion USD worldwide. The disease, caused by Clostridium perfringens, affects broilers, l…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Gourapura, Renukaradhya; Renu, Sankar
  • Licensing Officer: Dahlman, Jason "Jay"

A liposomal subunit flu vaccine formulation
TS-062211 — The Need: Addressing the Limitations of Current Flu Vaccines Influenza epidemics and pandemics present significant challenges to public health and global economies. Existing flu vaccines are strain-specific, providing limited cross-protective immunity and often lack long-term effectiveness. Additio…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Gourapura, Renukaradhya; Carson, Kennith; Cheng, Xingguo; Dhakal, Santosh; Lee, Chang Won; McDonough, Joseph
  • Licensing Officer: Dahlman, Jason "Jay"

Mannose Conjugated Chitosan-Based Swine Influenza Vaccine
TS-060542 — The Problem Swine influenza is an acute respiratory disease of pigs caused by swine influenza A virus (SwIAV). Pigs are naturally vulnerable to SwIAV-associated with secondary bacterial infections and is an economic threat to the global pig industry. Commonly circulating SwIAV strains in swine popu…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Gourapura, Renukaradhya
  • Licensing Officer: Dahlman, Jason "Jay"

Antimicrobial Breakthrough for Avian Bacterial Infections
TS-052320 — The Need: Antimicrobial Breakthrough for Avian Bacterial Infections Avian species, particularly chickens and turkeys, face significant economic losses due to bacterial infections caused by pathogenic Escherichia coli (APEC) and Salmonella strains (ST and SE). These bacteria not only harm avian popu…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Closs, Gary; Kathayat, Dipak
  • Licensing Officer: Dahlman, Jason "Jay"

Raman spectroscopy for detection of clinical and subclinical mastitis
TS-052242 — Mastitis is the both the most common and most expensive disease in the dairy industry. When it occurs in dairy cows, mastitis leads to deterioration in milk production and quality that causes a decrease in profitability. Therefore, early detection of bacterial infection in the udders is imperative…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Enger, Benjamin
  • Licensing Officer: Dahlman, Jason "Jay"

Antimicrobials to Control Campylobacter
TS-044474 — The Need: Addressing the Growing Threat of Foodborne Illness Foodborne illnesses caused by bacterial pathogens pose a significant public health concern worldwide, leading to millions of illnesses and thousands of deaths each year. Traditional antimicrobial therapies are facing challenges due to the…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Acuna, Ulyana Munoz; Antwi, Janet; Carcache de Blanco, Esperanza; Fuchs, James; Kumar, Anand; Nislow, Corey; Pascall, Melvin
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis
TS-040540 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
The Need: Combating Avian Pathogenic E. coli (APEC) Infections in Poultry Avian Pathogenic E. coli (APEC) poses a significant threat to the poultry industry worldwide, causing severe economic losses due to increased mortality and decreased growth rate of infected birds. Additionally, APEC is suspec…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecule growth inhibitors of avian pathogenic E. coli (APEC) as a means to control APEC infections in poultry.
TS-039568 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Control of Salmonella in poultry using new generation small molecule growth inhibitors
TS-039567 — Small molecule compounds that can be used to inhibit Salmonella growth for safe and sustainable poultry production.
The Need: Controlling Microbial Growth for Public Health and Safety The increasing incidence of foodborne illnesses caused by bacterial pathogens poses significant public health risks and economic burdens worldwide. Conventional antimicrobial treatments have become less effective, and the developme…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Miller, Sally; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Composition and oral delivery of nanoparticle based Salmonella vaccine for poultry
TS-038337 — A Salmonella oral vaccine to provide mucosal immunity and reduce bacterial shedding in poultry.
The Need: Salmonellosis, caused by Salmonella enterica serovar enteritidis (S. enteritidis), poses a significant health threat to both humans and poultry worldwide. It leads to substantial economic losses in the poultry industry and millions of deaths annually due to acute gastroenteritis and diarrh…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Gourapura, Renukaradhya; Renu, Sankar; Selvaraj, Ramesh
  • Licensing Officer: Dahlman, Jason "Jay"

Probiotic strains for reducing antibiotic resistance and modulating gut health
TS-037818 — A novel advancement to mitigate antibiotic resistance in the ecosystem.
The Need In today's world, the rapid emergence of antibiotic resistance (AR) poses a serious threat to public health, making it crucial to explore alternative strategies to combat this issue. Traditional approaches targeting pathogenic bacteria alone have proven insufficient due to the complexi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Hua; Wang, Zihua; Zhang, Lu; Zhou, Yang
  • Licensing Officer: Dahlman, Jason "Jay"

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