Available Technologies
# of Displayed Technologies: 15 / 15
Applied Category Filter (Click To Remove): Research & Development Tools
AI-Enabled Retrosynthesis for Drug Development
TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.
A time-consuming and costly step in drug development is the identification of drug-like small molecules that display desired properties against a specific biomolecular target and then the synthesis of such molecules if they do not exist. Retrosynthesis is a procedure where such a desired molecule i…
- College: College of Medicine (COM)
- Inventors: Ning, Xia; Chen, Ziqi
- Licensing Officer: Csatary, Erika
DAT-CI knock-in mouse model carrying a modified dopamine transporter that maintains the transport function but resistant to cocaine inhibition and thus showing no rewarding cocaine effects
TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.
Cocaine abuse has been an issue in the United States since the late 1980s. The highly addictive qualities along with the low cost ruined people’s lives and destroyed communities. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an overdose. Therefore, th…
- College: College of Medicine (COM)
- Inventors: Gu, Howard
- Licensing Officer: Davis, Stewart
NET-CI knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that maintains the transport function and makes the transporter protein resistant to cocaine and antidepressants
TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.
Cocaine abuse has been an issue in the United States since the late 1980s. Furthermore, antidepressants also quite dangerous, with nearly 14% of users (who have bipolar disorder) experiencing dependence. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an over…
- College: College of Medicine (COM)
- Inventors: Gu, Howard
- Licensing Officer: Davis, Stewart
Rabbit Model for Duchenne Muscular Dystrophy
TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.
There has yet to be a DMD animal model that bridges the gap between cost effectiveness and scientific relevance. This new rabbit model does that.
DMD is a lethal genetic disease characterized by progressive muscle weakness and muscle wasting. There are several animal models for DMD, includin…
- College: College of Medicine (COM)
- Inventors: Han, Renzhi
- Licensing Officer: Schworer, Adam
Low-Cost, Multiplexed Microfluidic Force Spectroscopy on-a-Chip
TS-057780 —
A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.
Development of several force spectroscopy strategies have enabled characterization of various types of molecular binding interactions with applications in biophysics, molecular biology and medicine. Despite various efforts to decrease the cost of force spectroscopy, full characterization of a mole…
- College: College of Engineering (COE)
- Inventors: Akbari, Ehsan; Castro, Carlos; Shahhosseini, Melika; Song, Jonathan
- Licensing Officer: He, Panqing
A novel mouse model of spontaneous chronic lymphocytic leukemia
TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.
The Need
Chronic lymphocytic leukemia (CLL) accounts for one quarter of new cases of leukemia. CLL is the most prevalent adult leukemia in Western countries and is characterized by a mature B-cell phenotype. Given the burden of this disease, a large pipeline of drugs for treatment are in progress…
- College: College of Medicine (COM)
- Inventors: Lapalombella, Rosa; Blachly, James; Byrd, John
- Licensing Officer: Schworer, Adam
Method for controlling multiple heterogenous magnetic bacteria at a solid-liquid interface using uniform magnetic fields
TS-053222 —
Manipulatable miniaturized robots have a variety of applications in biomedical sciences, specifically microrobots capable of navigating in vivo blood vessels have the potential to revolutionize non-invasive surgery and targeted drug delivery for cancer and other disease treatment. Drug discovery c…
- College: College of Arts & Sciences
- Inventors: Wijesinghe, Hiran
- Licensing Officer: Lawson, Ryan
Nras Mouse Melanoma Cell Lines
TS-049491 — Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that can be used for preclinical tumor immunology and cancer biology studies.
Studies show that 15-30% of melanomas are Nras driven and 60% of melanomas are Braf driven. Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that complement a set of Braf cell lines developed by Marcus Bosenberg at Yale Universit…
- College: College of Medicine (COM)
- Inventors: Burd, Christin; Murphy, Brandon
- Licensing Officer: Csatary, Erika
Novel Large Scale All-Male Bluegill Production Technology & All-Female Yellow Perch Production Technology
TS-043636 — A novel technique for the large scale production of male bluegill (GMB) stock through selective breeding methods and for large scale production of all female yellow perch fish stock by means of dietary supplements. This technique improves growth rate, size, and survivability. For more information, please see related pdf upload.
- College: College of Food, Agricultural, and Environmental Sciences (CFAES)
- Inventors: Wang, Hanping
- Licensing Officer: Dahlman, Jason "Jay"
Quadruplex-based non-enzymatic DNA signal amplification
TS-042905 — A quadruplex-based non-enzymatic DNA signal amplification scheme for point of care diagnostic testing.
Currently, non-enzymatic signal amplification assays, an alternative to PCR, are complicated reactions employing multiple DNA constructs. The most successful non-enzymatic assays rely on stand-displacement reactions within DNA duplexes that result in background activity. Because of this background…
- College: College of Arts & Sciences
- Inventors: Kankia, Besik
- Licensing Officer: Willson, Christopher
Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air
TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.
Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…
- College: College of Arts & Sciences
- Inventors: Badu-Tawiah, Abraham; Damon, Deidre
- Licensing Officer: Willson, Christopher
Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
- College: College of Arts & Sciences
- Inventors: Jaroniec, Christopher; Conroy, Daniel
- Licensing Officer: Willson, Christopher
CXCR3-GFP knock-in mouse
TS-038221 — A knock-in murine model that expresses high levels of GFP in CXCR3 positive cells.
Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and met…
- College: College of Arts & Sciences
- Inventors: Satoskar, Abhay; Oghumu, Steve
- Licensing Officer: Willson, Christopher
Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
- College: College of Arts & Sciences
- Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
- Licensing Officer: Willson, Christopher
Mutant Hydrogenase Bacteria for Use against Enteric Pathogens
TS-015013 — Hydrogenase enzyme deficient bacterial strains that may be used as vaccines or attenuating agents for enteropathogenic diseases.
Enteric pathogens are responsible for an estimated two million deaths annually and cause millions more cases of diarrheal illness even in developed countries. When an individual contracts an enteric pathogen such as S. typhimurium, the infected individual will continue to shed the pathogen for up …
- College: College of Medicine (COM)
- Inventors: Gunn, John
- Licensing Officer: Csatary, Erika
