TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.

TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.

TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.

TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.

TS-059106 — Rubber is a crucial material used worldwide, but it is becoming scarce due to high demand and limited areas to grow rubber trees. New methods and processes are needed to overcome the shortage of this essential material.

TS-059105 — Food shortages around the world affect hundreds of millions of people daily due to environmental and political issues. New technologies are needed to improve the quantity and quality of food in resource-limited areas.

TS-059103 — Novel temperature-sensitive SARS-CoV-2 mutant

TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.

TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.

TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.

TS-058447 — The emergence of quantum computing has uncovered a new set of error code detection and correction challenges. New technologies are needed to correct quantum and data transmission errors to accelerate the field’s growth and implementation.

TS-058408 — Freshwater resources around the world are under stress due to naturally occurring events and human impacts, causing an increase in cyanobacteria blooms. These cyanobacteria release harmful toxins, known as cyanotoxins. The proposed USV degrades the toxins on-site with UV light, reducing the accumulation of toxins, preventing groundwater contamination, and improving water quality.

TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.

TS-057780 — A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.

TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.

TS-057777 — A novel orally-active drug molecule that can inhibit pathological CD4+ T-cells at clinically translatable doses and, blunts progressive cardiac dysfunction and left-ventricular (LV) remodeling during Heart Failure (HF).

TS-057776 — A novel protein-drug conjugate of human serum albumin chemically conjugated to SN-38, solubilizing the potent chemotherapeutic. This therapy has the potential to treat many tumors with poor prognosis, including pancreatic, lung, breast, colorectal, ovarian, sarcoma, head and neck cancer, urothelial malignancies, and others.

TS-057739 — CRISPR/Cas 9 mediated targeting of MIR155HG in primary human T cells creates genomic deletions that disrupt transcription of mature microRNA-155 (miR-155, a miR associated with inflammation). Applying this treatment to donor T cells prior to allogenic hematopoietic stem cell transplantation (allo-HSCT) when treating hematological malignancies and other primary bone marrow disorders can prevent the development of aGVHD in patients.

TS-057129 — Algorithm for extracting 3D models, indexing them using a value-insensitive normalization algorithm, and comparing the model indexes to detect cloned 3D models.

TS-057127 — Achieving high efficiency LEDs with green, amber and longer wavelengths using III-nitride/II-IV-nitride heterostructures as the active media.

TS-056508 — Although demand for natural, high-quality, and preservative-free protein beverages is growing, current methods for producing these products are limited. Therefore, new approaches that generate highly tunable and natural products are needed to support health-promoting lifestyles.

TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.

TS-054917 — This invention ensures the consistent frequency of micro electro-mechanical system resonator-based oscillators by using a novel thin-layer stepped beam.

TS-054551 — Algorithm/software that dynamically classifies and removes clutter in systems such as the traffic management systems of Unmanned Aircraft Systems Traffic Management (UTM) and Urban Air Mobility (UAM).

TS-054550 — Sensing gases with high specificity and sensitivity in complex environments ranging from combustion processes to breath sensing using miniaturized solid-state electrochemical sensors.

TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.

TS-054040 — This is a new method of resistance spot welding of aluminum alloy and advanced high strength steel that creates a stronger bond by using a chromium-rich interlayer. The interlayer improves joint strength, ductility, and toughness compared to traditional methods.

TS-054019 — This technology improves the additive manufacturing process by aligning the multiple lasers to one reference point. The reference laser provides real time feedback to the other lasers thereby minimizing seam defects resulting in a higher quality print. .tb_button {padding:1px;cursor:pointer;border-right: 1px solid #8b8b8b;border-left: 1px solid #FFF;border-bottom: 1px solid #fff;}.tb_button.hover {borer:2px outset #def; background-color: #f8f8f8 !important;}.ws_toolbar {z-index:100000} .ws_toolbar .ws_tb_btn {cursor:pointer;border:1px solid #555;padding:3px} .tb_highlight{background-color:yellow} .tb_hide {visibility:hidden} .ws_toolbar img {padding:2px;margin:0px}

TS-054013 — The ultrasonically assisted wire additive manufacturing process and apparatus is a new innovation that uses power ultrasound (UA) for benefits in processing molten metals. The UA energy is directly applied in the local deposition pool, which makes this new hybrid process applicable for building parts with any size and geometry.

TS-054005 — This technology is a Vehicle-in-Virtual Environment (VVE) method for testing and evaluating Autonomous Vehicles (AV). The VVE approach is a safe, reliable, repetitive, and scalable method of testing AVs, decreasing the risks and costs of testing AVs on public roads.