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Revolutionary Modular Nuclear Reactor Core for Space Exploration
TS-066252 — Rotating Fuel Core with Fuel Strip(s) ("ROFFUS") is an innovative modular nuclear reactor core designed to provide reliable and scalable power for advanced space missions.
Future space missions require dependable, high-output energy sources to support operations such as material processing, transportation, and thermal conditioning, particularly in challenging environments like the lunar poles where sunlight is scarce. This advanced nuclear reactor core features a…
  • College: College of Engineering (COE)
  • Inventors: Smidts, Carol; Aldemir, Tunc; Cao, Lei Raymond; Horack, John; Khafizov, Marat
  • Licensing Officer: Zinn, Ryan

Advanced Sensor Arrays for Precise Gas Identification and Analysis
TS-066250 — A cutting-edge sensor system featuring p-n junctions in MOS materials for accurate detection and identification of gases.
In various industries, there is a growing demand for highly selective and sensitive gas sensors capable of accurately identifying specific gases within complex mixtures, addressing challenges in environmental monitoring, industrial safety, and healthcare diagnostics. This innovative sensor syst…
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Mondal, Suvra; Ssenyange, Solomon; Sun, Chenhu
  • Licensing Officer: Zinn, Ryan

Revolutionary NO Sensor for Highly Selective and Sensitive Gas Detection
TS-066249 — A novel sensor leveraging WO3 and Cr2O3 for selective NO detection in harsh environments and breath analysis with high sensitivity at ppb levels.
There is a critical demand for advanced gas sensors capable of selectively detecting nitric oxide (NO) in diverse applications such as environmental monitoring, industrial processes, and medical diagnostics, particularly in challenging environments with interfering gases like carbon monoxide (CO).…
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Mondal, Suvra; Ssenyange, Solomon; Sun, Chenhu
  • Licensing Officer: Zinn, Ryan

Metal oxide-based resistive type sensor for the detection of carbon monoxide at room temperature
TS-066246 — Our innovative CO sensor utilizes hydrated ruthenium oxide to detect carbon monoxide within a gas mixture with high sensitivity and selectivity at temperatures ranging from 25°C to 300°C.
Reliable and low-cost CO sensors with high sensitivity and selectivity are essential for environmental safety and industrial control, particularly to monitor combustion environments, automotive emissions, and various industrial processes, ensuring compliance with regulations and minimizing health …
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Adeyemo, Adedunni
  • Licensing Officer: Zinn, Ryan

Innovative High-Temperature NOx Sensor for Combustion Control
TS-066239 — There is a critical need for advanced high-temperature NOx sensors to accurately monitor and control combustion environments, ensuring compliance with government regulations and mitigating the harmful effects of NOx on ecosystems and public health. Our new NOx sensor is designed to detect total…
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Yang, Jiun-Chan
  • Licensing Officer: Zinn, Ryan

Compact High-Temperature Solid-State Potentiometric Oxygen Sensor
TS-066235 — Oxygen sensors are crucial for monitoring oxygen levels in combustion and industrial processes, but current sensors require complex plumbing for reference gas, limiting their placement and operational temperature range. There is a pressing need for a robust, high-temperature oxygen sensor that is …
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Akbar, Sheikh; Ramasamy, Ramamoorthy; Routbort, Jules; Singh, Dileep; Spirig, John
  • Licensing Officer: Zinn, Ryan

BDAMPER: Advanced Application Software for Dynamic Analysis and Design of Friction Damper Structures
TS-066234 — In the realm of rotating machinery and structural engineering, the need to manage and mitigate vibrations is paramount. Excessive vibrations can lead to material fatigue, operational inefficiency, and catastrophic failures. Industries require a sophisticated, accurate, and versatile tool to design…
  • College: College of Engineering (COE)
  • Inventors: Menq, Chia-Hsiang; Yang, Been-Der
  • Licensing Officer: Zinn, Ryan

3D Object-based Segmentation-based Quantification of Spatial Protein Organization (OBS3D)
TS-066233 — Protein analysis is foundational to understanding human physiology and is helpful for basic research, diagnosis, guiding treatment, and monitoring of human disease. There are several widely used platforms for evaluating protein function. The primary tools used in protein analysis on cells and tissues include antibody/aptamer, fluorescent detection systems, and mass spectrometry.
Colocalization analysis is the current standard technique for assessing spatial association of co‐labeled proteins in cells using multicolor immunofluorescence images. However, these tools are limited because multiple antigens nearby exhibit overlapping staining, which leads to inaccurate analys…
  • College: College of Engineering (COE)
  • Inventors: Veeraraghavan, Rengasayee
  • Licensing Officer: Zinn, Ryan

Innovative Solutions for Cell Viability and Targeted Delivery
TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications
The Need: Conventional electroporation methods often result in low cell viability due to heat generation, especially when working with primary cells. These methods also face challenges with non-specific transport of molecules, high vector integration rates leading to mutagenesis, and inefficacy in …
  • College: College of Engineering (COE)
  • Inventors: Gallego Perez, Daniel; Das, Devleena; Duarte Sanmiguel, Silvia; Higuita Castro, Natalia
  • Licensing Officer: Schultz, Teri

A Cybersecurity Vulnerability Prioritization System Including Identifying "Super-Critical" Vulnerabilities, predicting "Dark Host" Vulnerabilities, and Addressing Economic Costs
TS-066063 — Our cybersecurity vulnerability maintenance system stands as a pillar of modern security strategy, transforming reactive security measures into a preemptive defense mechanism. This integration of technology and economics ensures that your most critical assets are protected efficiently and effectively, making it an invaluable tool for any organization serious about security.
In today’s hyper-connected world, the escalation in cyber threats poses significant risks to organizational data and systems. Vulnerabilities within network infrastructures can lead to massive security breaches, as demonstrated by incidents like the 2017 Equifax hack. Effective vulnerability…
  • College: College of Engineering (COE)
  • Inventors: Allen, Theodore; Liu, Enhao
  • Licensing Officer: Zinn, Ryan

SimulationAI -- AI-Enabled Software Solution for Physics-Based Simulations
TS-066058 — By adopting our AI-driven solution, engineering teams can achieve more in less time, push the boundaries of innovation, and significantly cut down costs, all while maintaining or increasing the reliability and accuracy of their structural and material analysis. This is not just an evolution in FEM technology—it's a revolution.
In an era where precision and efficiency drive the success of engineering projects, the finite element method (FEM) remains indispensable but is burdened by high operational and computational costs. These costs often lead to overlooked uncertainty factors, suboptimal designs, and significant finan…
  • College: College of Engineering (COE)
  • Inventors: Soghrati, Soheil; vemparala, Balavignesh; Yang, Ming
  • Licensing Officer: Zinn, Ryan

Synthetic approaches for mitigating battery capacity loss in oxide anodes
TS-066056 — The Need The advancement of lithium-ion battery technology relies heavily on increasing energy density, yet practical usage of silicon (Si) anodes faces challenges due to parasitic side reactions and active lithium consumption. Controlling lithium amounts precisely while achieving uniform distribut…
  • College: College of Arts & Sciences
  • Inventors: Co, Anne; Hwang, Jisun; Lorie Lopez, Jose
  • Licensing Officer: Randhawa, Davinder

T-cells with Enhanced Ability to Respond to Exogenous Ligands
TS-066052 — Novel T-cells expressing the IL-2a receptor to enhance cancer cell targeting.
The Need As interest in cell-based therapies, particularly for cancer treatment, continues to rise, there’s a critical need for therapeutic cells capable of robust proliferation in vivo. Existing methods relying on exogenous cytokines like IL-2 face challenges due to dose-limiting toxicity an…
  • College: OSU Wexner Medical Center
  • Inventors: Rubinstein, Mark
  • Licensing Officer: Schultz, Teri

Novel Antibodies Targeting IL-2
TS-066051 — Novel antibodies targeting IL-2 with the ability to inhibit IL-2 signaling through IL-2 Rαβg to a greater extent than through IL-2 Rβg.
IL-2 and its receptor IL-2R are known to play multiple roles in shaping the immune response, including both immune activation and tolerance. Expression of intermediate-affinity IL-2 receptors by different immune cell subsets determines cellular sensitivity to IL-2. However, the dynamic interplay bet…
  • College: OSU Wexner Medical Center
  • Inventors:
  • Licensing Officer: Schultz, Teri

Anode synthesis using spray pyrolysis
TS-066037 — The Need In the realm of materials science and energy storage, there's a growing demand for innovative anode synthesis methods that yield materials with improved mechanical and electrochemical properties. Traditional synthesis techniques often fall short in achieving the desired performance met…
  • College: College of Arts & Sciences
  • Inventors: Co, Anne; Lorie Lopez, Jose
  • Licensing Officer: Randhawa, Davinder

Metal nitric oxides redox flow batteries
TS-066016 — The Need Redox flow batteries (RFBs) offer a promising solution for storing intermittent renewable energy in the electrical grid. However, their reliance on finite and unsustainable transition metals, such as vanadium, poses significant sustainability challenges. The rising costs and environmental …
  • College: College of Arts & Sciences
  • Inventors: Zhang, Shiyu; Park, Jaehyun
  • Licensing Officer: Randhawa, Davinder

Designing High-Donicity Anions for Rechargeable Potassium Superoxide/Peroxide Batteries
TS-066015 — The Need Over the past two decades, the advancement of metal-O2 batteries has been hindered by issues of instability, reversibility, and poor energy efficiency, primarily due to the instability of superoxide in the presence of Li+ and Na+ ions. Existing solutions such as Li-O2 and Na-O2 batteries h…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying
  • Licensing Officer: Randhawa, Davinder

Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
  • College: College of Medicine (COM)
  • Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
  • Licensing Officer: Schultz, Teri

System for automated high-speed imaging and genetic manipulation of C. elegans on agar media
TS-065892 — The Need The microscopic worm C. elegans is a model animal studied in more than 1500 biological and medical research laboratories worldwide due to its genetic manipulability and optical transparency. In C. elegans research, the manual process of picking worms between plates presents a significant …
  • College: College of Engineering (COE)
  • Inventors: Fang-Yen, Christopher "Chris"; Alhalbi, Serge; Li, Zihao
  • Licensing Officer: Randhawa, Davinder

Use of Potassium Permanganate to Remediate Pb and carcinogenic polyaromatic hydrocarbons (cPAH) in Urban Contaminated Soil
TS-065863 — The Need: Contaminated vacant lots pose significant environmental and health risks in urban areas, especially in lower-income neighborhoods. Anthropogenic activities such as mining, industrial processes, and combustion lead to the accumulation of organic pollutants and heavy metals like lead, arseni…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Lake, Loryssa; Basta, Nicholas
  • Licensing Officer: Wilburn, Adri

Method for sensitizing solid tumors to immunotherapy
TS-065862 — The Need In the landscape of cancer treatment, the emergence of immunotherapy has shown remarkable promise. However, its efficacy is not universal across all cancer types, and resistance development poses a significant challenge. Hyperprogression, characterized by accelerated tumor growth, further …
  • College: College of Arts & Sciences
  • Inventors: Kural, Comert; Djakbarova, Umidahan
  • Licensing Officer: Wilburn, Adri

Targeted Delivery to Cancer Cells using Self-assembled, Camptothecin Nanotubes: Active and Passive Targeting
TS-065860 — The Need: Cancer remains one of the most pressing medical challenges of our time, demanding innovative solutions to enhance treatment efficacy while minimizing systemic toxicity. Conventional chemotherapy agents often suffer from poor solubility, instability, and indiscriminate cytotoxicity, necessi…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Magliery, Thomas
  • Licensing Officer: Willson, Christopher

Advancing Canine Lung Cancer Care: Precision Diagnostics and Targeted Therapies
TS-065859 — FIELD: Revolutionizing Canine Lung Cancer Treatment The Need: Lung cancer in canines poses significant clinical challenges, mirroring the complexities of human lung cancer in non-smokers. With limited standard treatments beyond surgery, there's an urgent demand for advanced methods to assess, c…
  • College: College of Veterinary Medicine
  • Inventors: Lorch, Gwendolen
  • Licensing Officer: Dahlman, Jason "Jay"

Tomato Lines Resistant to Bacterial Spot (Rx-3, Xv3, QTL-11), Verticillium (Ve), and Fusarium (I)
TS-065858 — The Need: In the modern agricultural landscape, tomato crops face significant threats from bacterial spot, Verticillium, and Fusarium, leading to substantial yield losses and economic strain for growers. Addressing these challenges is crucial to ensure a sustainable and profitable tomato industry. …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Francis, David
  • Licensing Officer: Dahlman, Jason "Jay"

Soft Red Winter Wheat Line OH18-46-89
TS-065857 — The Need: In today's agricultural landscape, optimizing crop yield and quality is paramount to meet the growing demand for food. Farmers face the challenge of selecting crop varieties that offer resilience to various environmental stressors while maintaining high productivity levels. Additionall…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Sneller, Clay
  • Licensing Officer: Dahlman, Jason "Jay"

Malting Barley Variety RIL02FL-029
TS-065856 — The Need: As the demand for high-quality malting barley continues to rise, there is a pressing need for winter barley varieties that offer exceptional performance across various environmental conditions. Breweries and maltsters require reliable sources of malting barley to meet consumer demands for …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Stockinger, Eric
  • Licensing Officer: Dahlman, Jason "Jay"

Malting Barley Variety RIL523PFFN-033
TS-065855 — The Need: Breweries and malting facilities seek barley varieties that combine winter-hardiness, lodging resistance, early maturity, and high yield potential while meeting the stringent quality requirements of all-malt brewing. Meeting this demand ensures consistent and high-quality beer production, …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Stockinger, Eric
  • Licensing Officer: Dahlman, Jason "Jay"

Malting Barley Variety RIL02WI-013
TS-065854 — The Need: With the increasing demand for high-quality malting barley varieties, there is a pressing need for a winter barley line that can thrive in diverse environmental conditions while meeting the stringent requirements of the malting industry. Traditional barley varieties often struggle with win…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Stockinger, Eric
  • Licensing Officer: Dahlman, Jason "Jay"

Food-Grade Soybean Variety HS8-W179
TS-065853 — The Need: In the ever-evolving agricultural landscape, there is a critical need for food-grade cultivars that offer superior yields, enhanced protein content, and resistance to prevalent diseases. Farmers and agricultural stakeholders seek cultivars that not only optimize productivity but also ensur…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: McHale, Leah; Dorrance, Anne; Feller, Marcia; McIntyre, Scott; St Martin, Steven
  • Licensing Officer: Dahlman, Jason "Jay"

Winter Barley Variety- DH02UK-010
TS-065851 — There is a growing demand for winter barley varieties with enhanced traits such as winter-hardiness, lodging-resistance, and early maturity, particularly those suitable for malting purposes. Meeting this demand is essential for ensuring stable barley production and meeting the needs of the malting…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Stockinger, Eric
  • Licensing Officer: Dahlman, Jason "Jay"

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