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Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide superelastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to …
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

Automotive Security Assurance Testbed
TS-050056 — This testbed serves as a virtual way to increase security assurance in the automotive design phase. With connectivity becoming such a prominent aspect of automotive design security risks can also risk safety. The goal is to be able to provide a stronger assurance of security in modern vehicles.
The days where vehicles functioned in isloation are soon behind us. Push from consumers as well as the government has brought an age in which automobiles now function as complex systems of communication networks and sensors. As communication pathways within vehicles increase, the safety of their p…
  • College: College of Engineering (COE)
  • Inventors: Appel, Matthew; Ahmed, Qadeer; Oruganti, Pradeep Sharma
  • Licensing Officer: Hong, Dongsung

Physics Model-Based Attack Filter for a Controller Area Network (CAN)
TS-050050 — A method for filtering malicious messages on a CAN Network. This method is a physics, model, based method that utilizes knowledge of the CAN network as well as the physics of the systems being controlled to remove malicious messages from effecting the intended function of the controls algorithms on vehicles.
There has been a rapid increase in the number of embedded controllers used onboard vehicles. Connectivity and automation promise better safety, efficiency, and comfort. Vehicles in the future will be connected to more than just our personal devices, but to other vehicles and public infrastructure …
  • College: College of Engineering (COE)
  • Inventors: Appel, Matthew; Ahmed, Qadeer; Oruganti, Pradeep Sharma
  • Licensing Officer: Hong, Dongsung

Method for diagnosis and prognosis of Alzheimer's disease
TS-050046 — Methods using miRNAs for early Alzheimer’s Disease diagnoses and altered expression of key autophagy related proteins
The Need Alzheimer’s Disease (AD) is the most common cause of age-related dementia leading to severe and irreversible neurodegeneration and cognitive decline. Currently, AD has no cure or effective preventive approaches. Using current diagnostic techniques, AD cannot be clinically diagnosed b…
  • College: College of Medicine (COM)
  • Inventors: Amer, Amal
  • Licensing Officer: Flammang, Ann Marie

Device for Harvesting Vibration Energy to Power Remote Sensors or Feed the Power Grid
TS-049909 — A control method based upon properties of linear systems to manipulate the vibrational amplitudes and frequencies of structural systems by exploiting piecewise-linear (PWL) nonlinearities.
Energy harvesting from system vibrations is considered a promising green energy source with the capacity to both self-power small-scale devices and fulfill the need of large-scale electricity generation. A recent report by BCC research found that the markets for Vibration, Displacement, and Mechan…
  • College: College of Engineering (COE)
  • Inventors: D'Souza, Kiran; Tien, Meng-Hsuan
  • Licensing Officer: Zinn, Ryan

Point Prognostics: Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics
TS-049903 — A scalable, adaptive computational platform (software) that performs accurate, predictive computer simulations in less time, with the end goal of supporting a decision-making agency
A report by IOT Analytics evaluated the predictive maintenance (PdM) market at $1.5 billion in 2016 and anticipated a growth of 39% annually to $10.96 billion by 2022. Particle methods (broadly known as "Monte Carlo'' methods, or, MC) are a class of computational algorithms used in Pd…
  • College: College of Engineering (COE)
  • Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
  • Licensing Officer: Zinn, Ryan

Inhibition of DGAT for the treatment of cancer
TS-049730 — Dysregulated fat metabolism is an established hallmark of cancer cells. However, the disruption of lipid homeostasis in cancer cells remains an elusive target for therapy. Diacylglycerol-acyltransferase (DGAT) regulates the final and committed step for triglyceride synthesis. There are two known i…
  • College: College of Medicine (COM)
  • Inventors: Guo, Deliang
  • Licensing Officer: Ezzell, Janel

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-targeting activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases such as Duchenne muscular dystrophy (DMD) lacking effective therapeutic treatments. DMD is caused by genetic mutations in the DMD gene, which encodes the dystrophin protein. The mutations including missense point mutations, nonsense point mutations, deleti…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Davis, Stewart

A Novel Vaccine for Listeriosis Infection
TS-049471 — Listeriosis is an infectious disease caused by the bacterial pathogen Listeria monocytogenes. Although the average number of cases is moderate in the United States (1600-2500/year), listeriosis is a significant health concern due to its exceptionally high fatality rate. Indeed, listeriosis is the …
  • College: OSU Wexner Medical Center
  • Inventors: Seveau, Stephanie
  • Licensing Officer: Ezzell, Janel

Portable and automated mechanical ventilator with renewable energy source for harsh or remote environments
TS-048975 — A mechanical ventilation device which incorporates a hand-crank to enable automated breathing assistance without the need for electrical outlets or external generators.
Mechanical ventilators have been developed to provide automated, life-sustaining assistance to individuals with difficulty breathing due to either injury or chronic illness. Current ventilator systems, however, are expensive, require constant medical supervision and require reliable electrical pow…
  • College: OSU Wexner Medical Center
  • Inventors: Vazquez, Daniel; Haney, Amanda; Skidmore, Jeffrey
  • Licensing Officer: Zinn, Ryan

Stealth liposomes with greater stability for improved drug delivery
TS-048888 — Liposome drug delivery systems play a significant role in the formulation of new therapies. These liposome-encapsulated drugs are used to treat a wide range of diseases such as cancer, influenza, and hepatitis. While endogenous liposomes are recognized by the mononuclear phagocyte system and clear…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis
  • Licensing Officer: Ezzell, Janel

Electroreductive Recycling of Triphenylphosphine Oxide to Triphenylphosphine
TS-048738 — Novel electrochemical recycling method for selective and scalable reduction of triphenylphosphine oxide to triphenylphosphine
The Need Triphenylphosphine (TPP) is a widely used organic chemical, employed in everything from the pharmaceutical to the agro-chemical industries. TPP is a key reagent in many important synthetic pathways, including the Appel, Mitsunobu, Staudinger, and Wittig reactions, where it is stoichiometri…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Manabe, Shuhei
  • Licensing Officer: Bartell, Cordellia

Transition Metal Free Alkyne Hydrogenation and Semihydrogenation Catalysts
TS-048726 — Novel, transition metal-free catalysts capable of alkyne hydrogenation and semihydrogenation under modest conditions.
The Need Numerous industrial processes require alkyne semihydrogenation or hydrogenation reactions. For example, hydrogenation is necessary for the industrial-scale synthesis vitamin A, the creation of high molecular weight polymers, and the processing of petroleum into functionally useful derivati…
  • College: College of Arts & Sciences
  • Inventors: Goldberger, Joshua; Hodge, Kelsey
  • Licensing Officer: Bartell, Cordellia

A method to detect counterfeit integrated circuits through the use of a microwave resonator
TS-048646 — A novel method to detect a counterfeit integrated circuit (IC) and to authenticate an IC using the electromagnetic characteristics of the IC and a resonator
The presence of counterfeit integrated circuits (commonly referred to as “ICs” or “chips”) in a supply chain, such as a military supply chain, can result in either a failure of a critical system or a compromise of the data on that system. These counterfeit chips may not be …
  • College: College of Engineering (COE)
  • Inventors: Lee, Robert; Gildenmeister, Kraig
  • Licensing Officer: Hong, Dongsung

Photon-assisted MOCVD growth of II-IV-N2, II-III2-IV-N4 semiconductors and their heterostructures with III-N
TS-048645 — A novel photon-assisted MOCVD growth method to synthesize II-IV-N2 materials
Zn-IV-N2 and Mg-IV-N2 compounds have been reported to be synthesized by a number of techniques including chemical vapor deposition (CVD), vapor-liquid-solid (VLS) technique, ammonothermal synthesis, radio frequency (RF) sputtering, pulsed laser deposition, molecular beam epitaxy (MBE) and metalorg…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Rezaul Karim, Md
  • Licensing Officer: Hong, Dongsung

Dielectric heterojunction device
TS-048644 — The potential of different materials for vertical power switching is often assessed by calculating the Baliga Figure of Merit (BFOM). In the case of wide and ultra-wide bandgap materials, the high breakdown fields and the relatively good transport properties make the BFOM significantly higher than…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Moore, Wyatt; Xia, Zhanbo
  • Licensing Officer: Hong, Dongsung

Capacitive Sensing Method for Integrated Circuit Identification and Authentication
TS-048641 — A method of authenticating an IC die’s origin and uniquely identifying each die with an intrinsic unclonable value through measurement of on-chip capacitance values
Hardware security in Integrated Circuit (IC) designs is of increasing importance in dealing with the insecure, expanding global supply chain of these parts. The ability to trace the origin of a die, combined with the capability to uniquely identify each die provides valuable quantitative measures …
  • College: College of Engineering (COE)
  • Inventors: Khalil, Waleed; Kines, Michael
  • Licensing Officer: Hong, Dongsung

High Permittivity Dielectric Junction Termination for Vertical High Voltage Devices
TS-048635 — A novel edge termination concept using extreme permittivity dielectrics is proposed to effectively manage peak electric fields in vertical power devices
Gallium Nitride (GaN)-based devices are promising for high frequency and power applications because they have a superior combination of the critical electric field, electron mobility, saturation drift velocity, and power density. With the recent interest in solid-state power electronics technologi…
  • College: College of Engineering (COE)
  • Inventors: Lee, Hyunsoo; Rahman, Mohammad Wahidur "Wahidur"; Rajan, Siddharth; Xia, Zhanbo
  • Licensing Officer: Hong, Dongsung

Protecting UUID in Bluetooth Low Energy (from Sniffing and Fingerprinting)
TS-048632 — A method for mitigating the BLE vulnerability in an IoT device that protects UUIDs from being harvested and reverse engineered
Universally Unique Identifiers (UUIDs) in Bluetooth Low Energy (BLE) Devices are vital for nearby smartphone applications to discover them. BLE has also been increasingly used by Internet of Things (IoT) devices in various areas such as transportation, healthcare, wearables, retail, and smart home…
  • College: College of Engineering (COE)
  • Inventors: Lin, Zhiqiang; Wen, Haohuang; Zhang, Yinqian; Zuo, Chaoshun
  • Licensing Officer: Hong, Dongsung

A proximity sensor for the detection of hands on a steering wheel
TS-048591 — An embedded coax proximity sensor for the detection of hands or other objects near a vehicle's steering wheel
The coming age of autonomous vehicles will require the development of many new technologies to keep the vehicle occupants safe even when no one is paying attention to the vehicle operation. At present, given the limited capabilities of autonomous vehicles, it is necessary for the driver to monitor…
  • College: College of Engineering (COE)
  • Inventors: Lee, Robert; Kiourti, Asimina; Wang, Zhenyu
  • Licensing Officer: Hong, Dongsung

A Lightweight Low Inductance Power Module with Insulated Baseplates
TS-048588 — A lightweight power module that reduces loop stray inductance while maintaining good electrical insulation and thermal dissipation.
In conventional power module structures, the die is attached to the substrate, usually direct bonding copper (DBC). The ceramic substrate layer provides electrical insulation between the circuit and cooling structure and attaches to a conductive baseplate material (Cu, Al, AlSiC) to dissipate heat…
  • College: College of Engineering (COE)
  • Inventors: Lyu, Xintong; Wang, Jin
  • Licensing Officer: Hong, Dongsung

Method for Automatic Transmission Calibration and Controller Optimization
TS-048123 — A method for automatically calibrating and optimizing gear shift control parameters through iterative algorithms both during development and during use.
As fuel efficiency standards for modern cars increase, manufacturers are adding more and more gears to their transmissions. The higher number of gears allows for greater gear spread, meaning engineers can add taller gears that allow engines to operate at lower, more fuel-efficient rpms. Despite…
  • College: College of Engineering (COE)
  • Inventors: Mishra, Kirti; Srinivasan, Krishnaswamy
  • Licensing Officer: Gooray, Arthur "Art"

High-strength/high-ductility magnesium sheet alloy for room-temperature forming
TS-048065 — A new magnesium alloy designed using computational thermodynamic and kinetic models, which possesses optimal mechanical and formability performance suitable for industrial applications
Magnesium (Mg), the lightest structural metal, and its alloys, with their high specific strength and low density, are promising lightweight materials for industrial applications in automotive, aerospace, and electronic sectors. A 2019 report by Business Communications Company (BCC) Research highli…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua (Alan); Shi, Renhai
  • Licensing Officer: Zinn, Ryan

Integrated Biomanufacturing System for Fiber-Reinforced Tissue Composites
TS-047830 — An automated technique and system which combines electrospinning, additive manufacturing, and cell dispensing for generating high-quality tissue constructs with high physiological relevance.
Recent advances in biofabrication introduced by additive manufacturing/3D printing (AM/3DP) have significantly improved the overall architecture control in tissue engineered constructs. These constructs have a wide variety of important research and clinical applications including, but not limited …
  • College: College of Engineering (COE)
  • Inventors: Zhang, Xu; Herderick, Edward; Niu, Ye "Ye"; Zhao, Yi
  • Licensing Officer: Zinn, Ryan

3D subwavelength photonic detector coupled with dielectric resonator antenna
TS-047335 — New IR detector combining a dielectric resonator antenna (DRA) with a semiconductor absorber for improved signal, noise, and speed performance
The three essential characteristics of detectors are signal, noise, and speed. There are inherent trade-offs in these three figures of merit and various applications emphasize one or more characteristics. The primary limitation for infrared detectors and imagers is the limit on the achievable sign…
  • College: College of Engineering (COE)
  • Inventors: Krishna, Sanjay; Ball, Christopher; Grbic, Anthony; Kazemi, Alireza; Ranjbar, Amin; Ronningen, Theodore; Shu, Qingyuan
  • Licensing Officer: Hong, Dongsung

Gas Sensors for Health Monitoring and Diagnostics
TS-047136 — A range of low-cost gas sensors for non-invasive diagnostic tests and health monitoring.
Exhaled human breath is a combination of hundreds of gases including inorganic molecules such as NO, NH3 or CO, and volatile organic molecules such as acetone, ethane, and isoprene. Some of these gases are produced by the body as the result of physiological processes. Known as ‘biomarkers&rs…
  • College: College of Engineering (COE)
  • Inventors: Gouma, Pelagia-Iren
  • Licensing Officer: Gooray, Arthur "Art"

Analogues of the Epipolythiodioxopiperazine Alkaloids
TS-047118 — Analogues of verticillin which have more useful drug-like properties than the verticillin parent compounds alone, including increased solubility, absorption, and stability, all while maintaining similar anticancer potency to the original compounds.
Verticillins, which are epipolythiodioxopiperazine (ETP) alkaloids, have shown promising anticancer qualities; these fungal metabolites have exhibited high potency against a variety of tumor cell types, with IC50 values typically in the 10-500 nanomolar range. However, these compounds suffer from …
  • College: College of Pharmacy
  • Inventors: Fuchs, James; Huntsman, Andrew
  • Licensing Officer: Flammang, Ann Marie

ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Norris, Francis "Frank"

Isolation of an Ohio Porcine Epidemic Diarrhea Virus (PEDV) PC22A Strain in Cell Culture
TS-046905 — Porcine epidemic diarrhea virus (PEDV) has historically been an exotic disease to the U.S.. As of May, 2013, the virus made its way from China to the U.S.. This virus causes nearly 100% mortality in piglets and ranges from 80-90% morbidity. There is currently no PEDV vaccine in production. This inve…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Saif, Linda; Oka, Tomoichiro; Wang, Qiuhong
  • Licensing Officer: Dahlman, Jason "Jay"

Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Davis, Stewart

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