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Dynamic Nanobiosensor Platform for Viral and Tumor Nucleic Acid Detection
TS-052072 — A rapid, nucleic acid-based, point-of-care diagnostic.
The current gold-standard molecular diagnostic assay, quantitative reverse transcriptase (RT)-PCR, although accurate, is labor intensive (5-step workflow) and time consuming. Due to centralized laboratory testing, the time to results for RT-PCR can vary from 1 day up to 2 weeks, depending on the s…
  • College: College of Engineering (COE)
  • Inventors: Halley, Patrick; Castro, Carlos; Lucas, Christopher; Marras, Alexander; Shahhosseini, Melika
  • Licensing Officer: Ezzell, Janel

Novel Electrode for Co-factor Regeneration
TS-051995 — Method of regenerating NADPH for the production of biobutanol.
The Need NAD(P)H is used as a reducing co-factor for the synthesis of biochemicals (e.g., conversion of aldehydes to alcohols) using biocatalysts or even microbes. Butanol is an important feedstock used in the chemical industry and shows great potential as a biofuel. Butanol is produced from fossil…
  • College: College of Engineering (COE)
  • Inventors: Kadowaki, Jonathan; Gopalan, Venkat; Jones, Travis; Sengupta, Anindita; Subramaniam, Vishwanath
  • Licensing Officer: Bartell, Cordellia

Novel Ergonomic Scalpel Handle
TS-051663 — Alleviate and prevent occupational stresses using this novel scalpel design.
A highly unfortunate outcome of the 2020 coronavirus pandemic is the over 200,000 American deaths that have unexpectedly overloaded medical autopsy services across the United States. With this heightened need for autopsy services previously unseen occupational hazards relating to repetitive motion…
  • College: College of Medicine (COM)
  • Inventors: Sachire, Jennifer
  • Licensing Officer: Ezzell, Janel

Activation of human Argonaute3 (AGO3) using cityRNAs
TS-051298 — MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression post-transcriptionally. Their sequences differ, but their lengths fall within a range of ~20-23 nucleotides because the precursor miRNAs are processed by Dicer. Dicer cleaves long double-stranded RNA (dsRNA) molecules into s…
  • College: College of Arts & Sciences
  • Inventors: Nakanishi, Kotaro; Park, Mi Seul
  • Licensing Officer: Ezzell, Janel

Modular Dc Circuit Breaker with Integrated Energy Storage for Future Dc Networks
TS-051200 — Traditional AC distribution is not suitable for a wide range of applications in regard to efficiency, cost, and power carrying capacity compared to alternative distributions. Low voltage distribution suffers from high transmission losses due to higher current requirements necessitating thicker, he…
  • College: College of Engineering (COE)
  • Inventors: Wang, Jin; Na, Risha; Zhang, Yue
  • Licensing Officer: Hong, Dongsung

Development of a live attenuated vaccine for leishmaniasis using CRISPR technology
TS-051167 — Methods of production and use of modified Leishmania species and compositions of live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions.
Leishmaniasis is a neglected tropical disease caused by infection with protozoans of the 15 genus Leishmania that is transmitted by infected sand flies. Worldwide, an estimated 1 billion people are at risk of infection in tropical and subtropical countries, with up to 1.7 million new cases in 98 c…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay
  • Licensing Officer: Davis, Stewart

Wireless Identification of Viral Infection (WiVi)
TS-051091 — This invention introduces a novel method for airborne viral pandemic mitigation using WiFi access points as infrastructural spatiotemporal anchors.
New viruses are constantly being discovered. From SARS to Bird Flu, and HIV to COVID-19. The threat of global pandemics is real and methods for tracing and controlling it need to be available. It is necessary that there are capabilities available which can inform the modeling of future viral spre…
  • College: College of Engineering (COE)
  • Inventors: El Gamal, Hesham
  • Licensing Officer: Hong, Dongsung

Concept Discovery from Text via Knowledge Transfer
TS-050856 — A better way for systems to organize, file, or index documents or content based on actual or anticipated information needed in the form of a user query or natural language question.
Data Processing and (IT)-related activities, ranging from web hosting to automated data entry services are more important than ever due to the large amounts of data collected through technology. According to IBIS World, "Companies will increasingly capture more data, requiring the outside exp…
  • College: College of Engineering (COE)
  • Inventors: Das, Manirupa; Fosler-Lussier, John Eric; Ramnath, Rajiv
  • Licensing Officer: Hong, Dongsung

Ultra-high-throughput sequencing approach enabling whole-community COVID-19 screening
TS-050647 — REMBRANDT: a high-throughput Next Generation Sequencing-based approach for the simultaneous screening of over 100,000 COVID-19 samples per day.
The SARS-CoV-2 virus, which causes COVID-19 syndrome, has rapidly spread throughout the world and was recently classified by the WHO as a pandemic pathogen. Severe disease that requires hospital admission occurs in 20% of cases, and a subset of these patients require ICU care; the death rate from …
  • College: College of Medicine (COM)
  • Inventors: Palmieri, Dario; Fishel, Richard; Miles, Wayne; Siddiqui, Jalal "Jalal"
  • Licensing Officer: Ezzell, Janel

Method of forming low turn on and high breakdown voltage lateral diode.
TS-050626 — A hybrid Schottky and metal/high K dielectric/semiconductor contact to realize higher breakdown and low turn-on voltage for lateral diode based on wide bandgap semiconductors.
Practical realization of high breakdown fields in wide bandgap semiconductors such as GaN, SiC, typically requires the use of p-n junction, which require a turn-on voltage comparable to the bandgap of these semiconductors. For lower voltage applications, the forward or ON-state power loss due to h…
  • College: College of Engineering (COE)
  • Inventors: Rahman, Mohammad Wahidur "Wahidur"; Rajan, Siddharth
  • Licensing Officer: Hong, Dongsung

Method for selective area doping of Gallium Nitride
TS-050625 — A method of selectively obtaining n- and p-type regions from the same III-Nitride layer deposited on a substrate without using diffusion or ion-implantation techniques.
According to IBIS World Reports, manufacturers of electronic components will likely refocus their production away from silicon-based products to wide bandgap (WBG) semiconductors, which are made of materials that have a wider bandgap than silicon. A bandgap, or energy gap, denotes the energy diffe…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Chandrasekar, Hareesh; Rahman, Mohammad Wahidur "Wahidur"
  • Licensing Officer: Hong, Dongsung

Novel acellular vaccine for protection against Bordetella infection
TS-050524 — Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced mortality due to pertussis. Des…
  • College: College of Medicine (COM)
  • Inventors: Deora, Rajendar; Mishra, Meenu; Sukumar, Neelima
  • Licensing Officer: Ezzell, Janel

Method for seamless joining and repair of metal parts using ultrasonic additive manufacturing
TS-050479 — This invention provides a method for repairing metal parts by removing and replacing worn, damaged, or defective metal material. It also serves as a method for seamlessly joining metal sheets and other parts while retaining the original temper of the joined parts. This technology, based on ultrasonic additive manufacturing (UAM), achieves strong joints and repairs by enabling the filling of a channel that has been cut, formed, or otherwise created in a metal structure or between two metal structures.
The aircraft industry lacks a robust method for joining metal sheets, structures, and assemblies together in wings, fuselages, and engines. Fusion based welding methods cannot always be used because they create heat-affected zones, which reduce the mechanical performance of material around the wel…
  • College: College of Engineering (COE)
  • Inventors: Dapino, Marcelo; Gingerich, Mark; Headings, Leon
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Mini-PCDH15 for treatment of deafness
TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.
Mutations in PCDH15 cause Usher 1F, a recessive syndrome characterized by profound congenital deafness and absence of vestibular function, and progressive blindness beginning in the second decade. Because patients who lack hearing and balance rely on vision for communication and mobility, the late…
  • College: College of Arts & Sciences
  • Inventors: Sotomayor, Marcos
  • Licensing Officer: Ezzell, Janel

SARS-CoV-2 Diagnostic Assay with Sensors of Immune Activation
TS-050296 — A sequencing-based diagnostic assay for SARS-CoV-2 with sensors of immune activation and the viral microbiota.
Diagnosis of SARS-CoV-2 infection, which is responsible for COVID-19 disease, is typically performed by molecular analysis of upper respiratory sampling (e.g. nasal swab). Transcriptional-mediated amplification (TMA) and quantitative (real-time) polymerase chain reaction (qPCR) using one or more v…
  • College: College of Medicine (COM)
  • Inventors: Jones, Daniel "Dan"; Avenarius, Matthew; Tu, Huolin
  • Licensing Officer: Ezzell, Janel

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: Hong, Dongsung

Scalable laser-assisted MOCVD chamber design with laser array input
TS-050244 — A design of scalable laser-assisted MOCVD chamber for III-nitrides and other semiconductors with a laser array input.
III-nitrides represent an important semiconductor material system for both optoelectronic and power electronic device applications. Advantages for III-nitrides include high electron saturation velocity, high critical electric field, high radiation resistance and decent thermal performance. Therefo…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying
  • Licensing Officer: Hong, Dongsung

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Apoprotein manufacturing and methods for protein purification
TS-050238 — Methods of purifying proteins that can be used in various applications such as drug delivery, bioimaging and hemolysis treatment.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
TS-050232 — Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
Technology continues to advance and with it, a push for higher performance of electrical components and devices, especially in the transportation industry. For example, in the past few decades, considerable efforts have been taken towards aircraft electrification. Traditional hydraulic and pneumat…
  • College: College of Engineering (COE)
  • Inventors: Zhang, Julia; Peng, Peng; Xu, Longya
  • Licensing Officer: Hong, Dongsung

Novel Natural Product Derivatives Targeting Chronic Diseases
TS-050220 — Novel natural products and derivatives thereof that exhibit potent in vitro and in vivo activity
The Need Metabolic disorders such as type 2 diabetes are a major health concern that have impacted hundreds of millions of adults worldwide. Current pharmaceutical therapies for type 2 diabetes have been associated with adverse reactions including weight gain and increased risk of infection, liver …
  • College: College of Pharmacy
  • Inventors: Carcache de Blanco, Esperanza; Anaya Eugenio, Gerardo David; Eggers, Nicole
  • Licensing Officer: Ezzell, Janel

An Optical Fiber-Based Gamma Thermometer with Simple Design and Potential for Adjustable Axial Segmentation
TS-050215 — This invention proposes that an Optical Fiber-Based Gamma-Ray Calorimeter (OFBGC) sensor array can be designed, which does not require the distinct metallic thermal masses that are a part of the Optical Fiber-Based Gamma Thermometer (OFBGT).
As the world continues to grow and industrialize, the need for safe and efficient power is paramount. Currently, in nuclear fission reactors, there are Local Power Range Monitors (LPRM). They are ion chambers that contain fissile material. The electric current between their anode and cathode is mo…
  • College: College of Engineering (COE)
  • Inventors: Blue, Thomas E.; Birri, Anthony "Tony"
  • Licensing Officer: Hong, Dongsung

Fiber-to-fiber platform for multi-layer ferroelectric on insulator waveguide devices
TS-050208 — The invention is a fiber-to-fiber solution that allows the advantages of lithium niobate on insulator integrated photonic chips to be exploited in real world fielded systems.
Technology is advancing faster than ever, with major demand for instant communication and instant information among other industries. In order to facilitate this ever-growing industry, a technology called waveguides were invented. A waveguide confines the wave to propagate in one dimension, so tha…
  • College: College of Engineering (COE)
  • Inventors: Reano, Ronald; Nagy, Jonathan "Tyler"; Prabhakar, Karan
  • Licensing Officer: Hong, Dongsung

Redox Relay Flow Batteries: hybrid systems for scalable, high-capacity batteries.
TS-050105 — This application relates generally to a novel redox relay flow batteries comprising redox-active solids configured to behave as storage materials and redox-active organic molecules configured to behave as energy shuttles.
The Need The growing global demand for electrical energy has increased research efforts towards the integration of renewable energy sources into the electrical grid. Generation of energy from petroleum-based sources dominates the current market, but dependence on renewable energy is expected to gro…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Wong, Curt
  • Licensing Officer: Bartell, Cordellia

Integrally Joined Stainless Steel-NiTi Medical Devices
TS-050057 — A method for manufacturing surgical tools and implants with strong, gapless joints between NiTi (Nitinol) and stainless steel to capitalize on the best properties of both materials.
NiTi (Nitinol) is widely accepted and used for medical devices such as surgical tools and implants due to its biocompatibility and unique thermal-mechanical properties which provide super-elastic or shape memory responses. However, there are currently no commercial solutions for joining of NiTi to…
  • College: College of Engineering (COE)
  • Inventors: Panton, Boyd; Dapino, Marcelo; Gingerich, Mark; Headings, Leon; Morris, Jennifer
  • Licensing Officer: Zinn, Ryan

Physics Model-Based Attack Filter for a Controller Area Network (CAN)
TS-050050 — A method for filtering malicious messages on a CAN Network. This method is a physics, model, based method that utilizes knowledge of the CAN network as well as the physics of the systems being controlled to remove malicious messages from effecting the intended function of the controls algorithms on vehicles.
There has been a rapid increase in the number of embedded controllers used onboard vehicles. Connectivity and automation promise better safety, efficiency, and comfort. Vehicles in the future will be connected to more than just our personal devices, but to other vehicles and public infrastructure …
  • College: College of Engineering (COE)
  • Inventors: Ahmed, Qadeer; Appel, Matthew; Oruganti, Pradeep Sharma
  • Licensing Officer: Hong, Dongsung

Method for diagnosis and prognosis of Alzheimer's disease
TS-050046 — Methods using miRNAs for early Alzheimer’s Disease diagnoses and altered expression of key autophagy related proteins
The Need Alzheimer’s Disease (AD) is the most common cause of age-related dementia leading to severe and irreversible neurodegeneration and cognitive decline. Currently, AD has no cure or effective preventive approaches. Using current diagnostic techniques, AD cannot be clinically diagnosed b…
  • College: College of Medicine (COM)
  • Inventors: Amer, Amal
  • Licensing Officer: Ezzell, Janel

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