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AI-Enabled Retrosynthesis for Drug Development
TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.
A time-consuming and costly step in drug development is the identification of drug-like small molecules that display desired properties against a specific biomolecular target and then the synthesis of such molecules if they do not exist. Retrosynthesis is a procedure where such a desired molecule i…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Chen, Ziqi
  • Licensing Officer: Csatary, Erika

FraB as a drug target and FraB inhibitors as Salmonella-specific narrow-spectrum therapeutics
TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.
Non-typhoidal salmonellosis is one of the most significant food-borne diseases, in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics available to treat the disease. However, antibiotic resistance is on the ris…
  • College: College of Medicine (COM)
  • Inventors: Ahmer, Brian; Boulanger, Erin; Cool, Austin; Gopalan, Venkat; Kovvali, Sai Sravya Varali; Law, Jamison; Lindert, Steffen; Sabag-Daigle, Anice; Sengupta, Anindita; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Csatary, Erika

Diagnostic for Early Detection of Heart Damage
TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.
Despite significant medical advances and technologies, cardiovascular disease remains the number one cause of death in the United States, irrespective of gender or race, resulting in more than 600,000 annual deaths. Additionally, while cancer survivorship has increased significantly, the number one …
  • College: College of Medicine (COM)
  • Inventors: Smith, Sakima; Dib, Patrick; McElroy, Craig
  • Licensing Officer: Csatary, Erika

Metabolite-Based Diagnostics for Joint Infection
TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.
Pseudomonas aeruginosa, a biofilm-producing pathogenic bacterium, exhibits resistance to many antibiotics. This leads to acute and chronic joint infections that are difficult to treat. Accordingly, a critical need exists for accurate biofilm diagnosis, prevention, and treatment. While culture-free…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Bruschweiler, Rafael; Leggett, Abigail
  • Licensing Officer: Csatary, Erika

High Purity Extraction of Rubber From Taraxacum
TS-059106 — Rubber is a crucial material used worldwide, but it is becoming scarce due to high demand and limited areas to grow rubber trees. New methods and processes are needed to overcome the shortage of this essential material.
The Need Natural rubber is a critical raw material in many industrial supply chains because of its unique properties, such as high durability, flexibility, and water resistance, make it invaluable for a wide range of products, including high-performance auto and aircraft tires, electronic cables, a…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Michel, Frederick; Ramirez Cadavid, David
  • Licensing Officer: Dahlman, Jason "Jay"

A low input high yield indoor food production module
TS-059105 — Food shortages around the world affect hundreds of millions of people daily due to environmental and political issues. New technologies are needed to improve the quantity and quality of food in resource-limited areas.
The Need Globally, about 690 million people regularly go to bed hungry, which is expected to rise to more than 890 million by 2030. Food shortages are commonly caused by drought, pests, too much rain, land shortages, and political unrest. As a result, there is an unmet need to develop new technolog…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Ling, Peter; Tkach, Christopher
  • Licensing Officer: Dahlman, Jason "Jay"

Temperature-sensitive SARS-CoV-2 mutant TS11 for vaccine development
TS-059103 — Novel temperature-sensitive SARS-CoV-2 mutant
Current COVID-19 vaccines (mRNA, adenovirus vector, inactivated, S protein) are effective in preventing severe COVID-19 cases and deaths. However, they do not prevent infection/virus transmission and as the virus continues to evolve, S mutants may emerge that can escape current vaccine-induced immun…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Qiuhong; Liu, Mingde; Niu, Xiaoyu; Saif, Linda; Xu, Jiayu
  • Licensing Officer: Dahlman, Jason "Jay"

SimPi: A Remote Power Platform for Simulation
TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.
Simulations are essential for evaluating the potential impacts of disasters and for creating effective preparedness and response plans to facilitate organized and coordinated actions. Since response plans are not theoretical exercises, they must frequently be tested to be evaluated, adapted, and u…
  • College: College of Medicine (COM)
  • Inventors: Winfield, Scott; Beck, James; Finnegan, Geoff
  • Licensing Officer: Csatary, Erika

DAT-CI knock-in mouse model carrying a modified dopamine transporter that maintains the transport function but resistant to cocaine inhibition and thus showing no rewarding cocaine effects
TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.
Cocaine abuse has been an issue in the United States since the late 1980s. The highly addictive qualities along with the low cost ruined people’s lives and destroyed communities. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an overdose. Therefore, th…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Davis, Stewart

NET-CI knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that maintains the transport function and makes the transporter protein resistant to cocaine and antidepressants
TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.
Cocaine abuse has been an issue in the United States since the late 1980s. Furthermore, antidepressants also quite dangerous, with nearly 14% of users (who have bipolar disorder) experiencing dependence. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an over…
  • College: College of Medicine (COM)
  • Inventors: Gu, Howard
  • Licensing Officer: Davis, Stewart

New Class of Error Correction Codes for Quantum Computing
TS-058447 — The emergence of quantum computing has uncovered a new set of error code detection and correction challenges. New technologies are needed to correct quantum and data transmission errors to accelerate the field’s growth and implementation.
The Need Transmitting data over networks is an essential component across a multitude of applications, including communications, manufacturing, aerospace, satellite communications, quantum computing, and many others. Therefore, detecting and correcting errors during data transmission is of utmost i…
  • College: College of Arts & Sciences
  • Inventors: Joshua, Roy
  • Licensing Officer: Dahlman, Jason "Jay"

Water treatment to eliminate cyanobacteria and other toxins by unmanned surface vehicles (USVs)
TS-058408 — Freshwater resources around the world are under stress due to naturally occurring events and human impacts, causing an increase in cyanobacteria blooms. These cyanobacteria release harmful toxins, known as cyanotoxins. The proposed USV degrades the toxins on-site with UV light, reducing the accumulation of toxins, preventing groundwater contamination, and improving water quality.
Treatment of cyanobacteria and cyanotoxins is necessary before they reach a critical point, or they can contaminate other environments. For example, waste produced by water treatment facilities serves as fertilizer for agricultural land, and if not properly treated, toxic cyanobacteria can grow in…
  • College: College of Public Health
  • Inventors: Lee, Jiyoung; Byrd, Kendall
  • Licensing Officer: Csatary, Erika

Rabbit Model for Duchenne Muscular Dystrophy
TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.
There has yet to be a DMD animal model that bridges the gap between cost effectiveness and scientific relevance. This new rabbit model does that. DMD is a lethal genetic disease characterized by progressive muscle weakness and muscle wasting. There are several animal models for DMD, includin…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi
  • Licensing Officer: Schworer, Adam

Low-Cost, Multiplexed Microfluidic Force Spectroscopy on-a-Chip
TS-057780 — A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.
Development of several force spectroscopy strategies have enabled characterization of various types of molecular binding interactions with applications in biophysics, molecular biology and medicine. Despite various efforts to decrease the cost of force spectroscopy, full characterization of a mole…
  • College: College of Engineering (COE)
  • Inventors: Akbari, Ehsan; Castro, Carlos; Shahhosseini, Melika; Song, Jonathan
  • Licensing Officer: He, Panqing

Anti-GARP Monoclonal Antibodies for Cancer Therapy
TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.
Although immune checkpoint blockade (ICB) has emerged as a promising cancer immunotherapy, a majority of tumors fail to respond to ICB. A potential mechanism driving this failed response is the accumulation of TGF-β1 in the tumor microenvironment (TME), which drives immune dysfunction by indu…
  • College: College of Medicine (COM)
  • Inventors: Li, Zihai
  • Licensing Officer: He, Panqing

An Orally Active, Selective Inhibitor of CD4+ T-Cell Activation That Blunts Left-Ventricular Remodeling and Improves Cardiac Function during Chronic Heart Failure
TS-057777 — A novel orally-active drug molecule that can inhibit pathological CD4+ T-cells at clinically translatable doses and, blunts progressive cardiac dysfunction and left-ventricular (LV) remodeling during Heart Failure (HF).
HF afflicts ~6.5 million adults in US with 50% mortality in first 5 years. It has an estimated market size of $4.2B USD in US alone with a forecasted CAGR of 23% from 2018-2028. Current HF treatments are mostly aimed at alleviating symptoms rather than treatment, resulting in progressive cardiac d…
  • College: College of Medicine (COM)
  • Inventors: Bansal, Shyam; Gumina, Richard
  • Licensing Officer: He, Panqing

Albumin-SN-38 Conjugate (AlbuCure) for Cancer Therapy
TS-057776 — A novel protein-drug conjugate of human serum albumin chemically conjugated to SN-38, solubilizing the potent chemotherapeutic. This therapy has the potential to treat many tumors with poor prognosis, including pancreatic, lung, breast, colorectal, ovarian, sarcoma, head and neck cancer, urothelial malignancies, and others.
Many solid tumors have poor prognosis despite recent progress in molecularly targeted therapy and immunotherapy. Irinotecan/CPT-11, a chemotherapy on the WHO Essential Medicines List, is approved for use in colorectal cancer, lung cancer, pancreatic cancer, gastric cancer, malignant glioma, and sa…
  • College: College of Medicine (COM)
  • Inventors: Williams, Terence; Lee, Robert
  • Licensing Officer: He, Panqing

Reduction in Incidence and Severity of Acute Graft-Versus-Host Disease (aGVHD) via CRISPR-Cas9 Deletion of the miR-155 Host Gene (MIR155HG) in Primary Human T Cells
TS-057739 — CRISPR/Cas 9 mediated targeting of MIR155HG in primary human T cells creates genomic deletions that disrupt transcription of mature microRNA-155 (miR-155, a miR associated with inflammation). Applying this treatment to donor T cells prior to allogenic hematopoietic stem cell transplantation (allo-HSCT) when treating hematological malignancies and other primary bone marrow disorders can prevent the development of aGVHD in patients.
The Need More than 8,000 patients receive allo-HSCT annually in the US alone as a cure for hematologic malignancies and other primary bone marrow disorders. However, the major barrier for the success of allo-HSCT is the high incidence of aGVHD and its associated morbidity and mortality. Acute GVHD…
  • College: College of Medicine (COM)
  • Inventors: Ranganathan, Parvathi; Garzon, Ramiro
  • Licensing Officer: He, Panqing

3DScope: Detecting 3D Model Clones
TS-057129 — Algorithm for extracting 3D models, indexing them using a value-insensitive normalization algorithm, and comparing the model indexes to detect cloned 3D models.
The unauthorized copying of 3D models robs designers of property, reduces innovation going into the creation of 3D models, creates liability for entities unknowingly using copied models, and indicates a lapse in IP security. With the vast amount of 3D assets in use, it is infeasible for humans to …
  • College: College of Engineering (COE)
  • Inventors: Zuo, Chaoshun; LIN, ZHIQIANG
  • Licensing Officer: Ashouripashaki, Mandana

High Efficiency LED Designs Using Quantum Well Engineering
TS-057127 — Achieving high efficiency LEDs with green, amber and longer wavelengths using III-nitride/II-IV-nitride heterostructures as the active media.
Although extensive research and development over the past two decades has resulted in close to 100% external quantum efficiency (EQE) of InGaN based blue light emitting devices, efficiency of the longer visible wavelength emitting devices has remained relatively low. Spontaneous polarization origi…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Zhang, Kaitian
  • Licensing Officer: Randhawa, Davinder

Blending Proteins for Improved Functionality
TS-056508 — Although demand for natural, high-quality, and preservative-free protein beverages is growing, current methods for producing these products are limited. Therefore, new approaches that generate highly tunable and natural products are needed to support health-promoting lifestyles.
The Need Consumers have substantial demand for customizable liquid foods, beverages, and dietary solutions that will help them more aggressively meet their unique nutrition and personal health goals. While there are many methods for producing various formulations, there is high interest in liquid f…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Balasubramaniam, V M "Bala"; Janahar, Jerish; Jimenez-Flores, Rafael
  • Licensing Officer: Dahlman, Jason "Jay"

A novel mouse model of spontaneous chronic lymphocytic leukemia
TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.
The Need Chronic lymphocytic leukemia (CLL) accounts for one quarter of new cases of leukemia. CLL is the most prevalent adult leukemia in Western countries and is characterized by a mature B-cell phenotype. Given the burden of this disease, a large pipeline of drugs for treatment are in progress…
  • College: College of Medicine (COM)
  • Inventors: Lapalombella, Rosa; Blachly, James; Byrd, John
  • Licensing Officer: Schworer, Adam

Micro-Resonator Design Implementing Internal Resonance for micro electro-mechanical systems (MEMS) Applications
TS-054917 — This invention ensures the consistent frequency of micro electro-mechanical system resonator-based oscillators by using a novel thin-layer stepped beam.
Computer processors are used every minute of every day in phones, cars, computers, TVs, and as the “Internet of Things” expands to refrigerators, toasters, and more processers define how we live our lives. These processors rely on mechanical oscillators and resonators that work togethe…
  • College: College of Engineering (COE)
  • Inventors: Cho, Han Na "Hanna"; Yu, Jun
  • Licensing Officer: Zinn, Ryan

Dynamic Removal of Clutter to Improve Situational Awareness in Traffic Management Systems
TS-054551 — Algorithm/software that dynamically classifies and removes clutter in systems such as the traffic management systems of Unmanned Aircraft Systems Traffic Management (UTM) and Urban Air Mobility (UAM).
The Unmanned Aerial Vehicle (UAV) market is predicted to be worth $56.18 billion by 2027. The global commercial UAV market size alone was valued at $13.44 billion in 2020, with a recorded demand of over 689,000 units. With a wide range of applications, the UAV market is expected to grow at 19.9% C…
  • College: College of Engineering (COE)
  • Inventors: Singhal, Achal
  • Licensing Officer: Zinn, Ryan

A Composite Semiconducting Metal Oxide Sensor for Detection and Analysis of Trace Ammonia
TS-054550 — Sensing gases with high specificity and sensitivity in complex environments ranging from combustion processes to breath sensing using miniaturized solid-state electrochemical sensors.
Optimizing industrial operations, environmental monitoring, and disease diagnosis all require sensing of gases with high sensitivity and selectivity. In addition, decreasing the footprint of the sensor allows sensing to be done in size-constrained spaces. The global gas sensor market size was valu…
  • College: College of Arts & Sciences
  • Inventors: Dutta, Prabir; Sun, Chenhu
  • Licensing Officer: Zinn, Ryan

X-Ray Assistive Device for Standardizing the Knee Templating Process
TS-054471 — Knee templating is used as part of the pre-operative planning for knee replacement to determine the best fit for an implant. The current assistive devices used to determine fit are unreliable and inaccurate for proper patient fit. A new device is suggested to overcome these limitations.
Over 600,000 knee replacements are performed per year. As part of the pre-operative planning for surgery, x-ray images are taken to determine the proper fit for the implant. Even with the use of a calibration ball, this knee templating procedure remains inaccurate and unreliable for a number of re…
  • College: College of Engineering (COE)
  • Inventors: Ruegsegger, Mark; Aery, Dylan; Browske, Kimberly; Cantrell, Kaleb "Kaleb"; Reilman, Zach; Thew, Maddie
  • Licensing Officer: Randhawa, Davinder

Enhancing the mechanical performance of resistance spot welding of aluminum alloys to steel using chromium-rich Interlayers
TS-054040 — This is a new method of resistance spot welding of aluminum alloy and advanced high strength steel that creates a stronger bond by using a chromium-rich interlayer. The interlayer improves joint strength, ductility, and toughness compared to traditional methods.
Resistance welding is used to combine two metals at one point. This technique is used extensively in automotive manufacturing, combining an aluminum (Al) to an advanced high strength steel (AHSS) structure. Welding Al and AHSS together directly, however, does not create a high-quality bond, due to…
  • College: College of Engineering (COE)
  • Inventors: Ramirez, Antonio J.; Lara, Bryan; Reghine Giorjao, Rafael Arthur
  • Licensing Officer: Zinn, Ryan

Method for aligning multiple lasers using axial sensor data.
TS-054019 — This technology improves the additive manufacturing process by aligning the multiple lasers to one reference point. The reference laser provides real time feedback to the other lasers thereby minimizing seam defects resulting in a higher quality print. .tb_button {padding:1px;cursor:pointer;border-right: 1px solid #8b8b8b;border-left: 1px solid #FFF;border-bottom: 1px solid #fff;}.tb_button.hover {borer:2px outset #def; background-color: #f8f8f8 !important;}.ws_toolbar {z-index:100000} .ws_toolbar .ws_tb_btn {cursor:pointer;border:1px solid #555;padding:3px} .tb_highlight{background-color:yellow} .tb_hide {visibility:hidden} .ws_toolbar img {padding:2px;margin:0px}
The additive manufacturing (AM) market has been steadily growing and has recently surpassed the $10 billion in market revenue. To keep up with this demand for less expensive, larger parts, users are turning to multi-laser machines to scale the technology. Each machine has a coordinate system w…
  • College: College of Engineering (COE)
  • Inventors: Rindler, Jacob
  • Licensing Officer: Zinn, Ryan

Ultrasonically assisted wire additive manufacturing process and apparatus
TS-054013 — The ultrasonically assisted wire additive manufacturing process and apparatus is a new innovation that uses power ultrasound (UA) for benefits in processing molten metals. The UA energy is directly applied in the local deposition pool, which makes this new hybrid process applicable for building parts with any size and geometry.
Additive manufacturing (AM) is the process of 3D printing for industrial use. Instead of countertop devices printing small toys from plastic, industrial AM is used on a much larger scale to create engine blocks, plane components, and many other products made of metal alloys. AM is traditionally do…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Pfeifer, Eddie "Ed"; Wang, Tianzhao
  • Licensing Officer: Zinn, Ryan

Vehicle-in-Virtual-Environment Method for Autonomous Driving System Development and Evaluation
TS-054005 — This technology is a Vehicle-in-Virtual Environment (VVE) method for testing and evaluating Autonomous Vehicles (AV). The VVE approach is a safe, reliable, repetitive, and scalable method of testing AVs, decreasing the risks and costs of testing AVs on public roads.
The demand for autonomous vehicles continues to grow as companies and cities realize the effect on the costs, safety, and efficiency that AVs have on everyday lives. Initiatives such as MCity in Detroit, Michigan, and Smart City in Columbus, Ohio, show a strong commitment to the development of aut…
  • College: College of Engineering (COE)
  • Inventors: Guvenc, Levent; Aksun Guvenc, Bilin
  • Licensing Officer: Randhawa, Davinder

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