# of Displayed Technologies: 10 / 12

Applied Category Filter (Click To Remove): Gene Therapy


Categories

CPT1a gene therapy for treating and preventing cardiovascular diseases
TS-075241 — Problem Cardiovascular diseases (CVDs) such as heart failure, myocardial infarction, and cardiomyopathies remain leading causes of death worldwide. Notably, heart failure is the only major cardiovascular condition still increasing in prevalence. Current treatments primarily consist in managing the …
  • College: College of Medicine (COM)
  • Inventors: Lewandowski, E. Douglas; Carley, Andrew
  • Licensing Officer: Willson, Christopher

Cancer mitochondria-targeted luminoptogenetics (mLumiOpto) to treat GBM and metastatic cancers
TS-075179 — Problem Mitochondria is a promising target for cancer treatment. However, current strategies to specifically and effectively destroy cancer mitochondria in vivo are limited. Solution Applications Competitive Advantages Seeking Opportunities for Licensing and collaboration
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Vitrectomy and Insulin Assisted Retinal Gene Therapy
TS-075164 — The Problem Treatments for inherited retinal diseases are currently limited. Gene therapy has emerged as a strong treatment option. However, difficulties have arisen with these gene therapies. It has been found that an intrathecal injection of adenoassociated viral (AAV) gene therapy vector does no…
  • College: College of Medicine (COM)
  • Inventors: Mendel, Thomas; Kaur, Sukhvinder
  • Licensing Officer: Willson, Christopher

Gene therapy for adipose neuropathy
TS-075160 — Problem Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart and subcutaneous white adipose tissue (scWAT). It is mostly associated with diabetes, obesity, aging, and chemotherapy. Affecting 10-20% of U.S. adults aged 50-70, PN is…
  • College: College of Medicine (COM)
  • Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
  • Licensing Officer: Willson, Christopher

Novel HIV Targeting Strategy for Next‑Generation Antivirals
TS-074218 — This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discovery, combination strategies, and next‑generation intervention concepts. The technology is designed to complement current HIV treatment paradigms while supporting diversification of long‑term antiviral pipelines.
Technology Overview This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discove…
  • College: College of Arts and Sciences (COAAS)
  • Inventors: Musier-Forsyth, Karin; Kelley, Elise; Nielsen, Andrew
  • Licensing Officer: Panic, Ana

Innovative Solutions for Cell Viability and Targeted Delivery
TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications
The Need: Conventional electroporation methods often result in low cell viability due to heat generation, especially when working with primary cells. These methods also face challenges with non-specific transport of molecules, high vector integration rates leading to mutagenesis, and inefficacy in …
  • College: College of Engineering (COE)
  • Inventors: Gallego Perez, Daniel; Das, Devleena; Duarte Sanmiguel, Silvia; Higuita Castro, Natalia
  • Licensing Officer: Willson, Christopher

T-cells with Enhanced Ability to Respond to Exogenous Ligands
TS-066052 — Novel T-cells expressing the IL-2a receptor to enhance cancer cell targeting.
The Need As interest in cell-based therapies, particularly for cancer treatment, continues to rise, there’s a critical need for therapeutic cells capable of robust proliferation in vivo. Existing methods relying on exogenous cytokines like IL-2 face challenges due to dose-limiting toxicity an…
  • College: OSU Wexner Medical Center
  • Inventors: Rubinstein, Mark
  • Licensing Officer: Willson, Christopher

Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
  • College: College of Medicine (COM)
  • Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
  • Licensing Officer: Willson, Christopher

Gene Therapy Compositions for Treating Cardiovascular Diseases
TS-063091 — A gene therapy approach to address the specific needs of failing hearts.
Heart failure affects over 6 million adults in the US and can lead to irreversible damage to the heart. The Need In the realm of cardiovascular health and the management of heart-related disorders, there exists a pressing commercial need for a technology that can effectively address the challenge…
  • College: College of Medicine (COM)
  • Inventors: Lewandowski, E. Douglas; Carley, Andrew
  • Licensing Officer: Willson, Christopher

Treating Obesity and Cardiovascular Disease Via Genetic Manipulation of Skin Tissue
TS-062096 — Using tissue nano-transfection to regulate BAT and increase 12,13-diHOME production to treat obesity, cardiovascular disease and type 2 diabetes.
Cardiovascular disease (CVD) is the leading cause of death across the US and worldwide and affects almost half of all adults in the US. CVD encompasses a number of conditions that affect the heart and vasculature. CVD can arise in response to multiple factors, including obesity. Obesity elevates the…
  • College: College of Medicine (COM)
  • Inventors: Stanford, Kristin; Gallego Perez, Daniel; Ziolo, Mark
  • Licensing Officer: Willson, Christopher

Show More Technologies

Loading icon