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Self-assembled 3D RNA Cage Nanoparticles with Precise Shape and Size for Applications in Medical Sciences, Materials Sciences, Engineering and Nanotechnology
TS-039545 — Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery
One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building blocks. N…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Jasinski, Daniel; Khisamutdinov, Emil; Li, Hui
  • Licensing Officer: Flammang, Ann Marie

Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
  • College: College of Arts & Sciences
  • Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
  • Licensing Officer: Wohlgamuth, Christopher

A Closed Loop System for Responsive Precise Intraparenchymal Delivery of Adenosine for the Treatment of Epilepsy
TS-037644 — Medical device for controlling seizures.
Adenosinergic neuromodulation plays a crucial role in control of seizure activity and is described as the brain's endogenous anticonvulsant. Intraparenchymal infusion of adenosine into epileptogenic regions of the brain has been shown to control seizures (anti-ictogenic) and prevent progressiv…
  • College: College of Medicine (COM)
  • Inventors: Oluigbo, Chima
  • Licensing Officer: Paschall, Christopher

Environmental and Ship Motion Forecasting Program
TS-037401 — A system that will enable prediction of ship motion in order to improve cargo transfer, helicopter landing, and other naval/commercial operations such as those related to offshore platforms or wave energy generation systems.
Instantaneous and predictive information about sea waves is critical to forecast ship motion, which is needed for many applications, such as cargo transfer and helicopter landing at sea. Scientists use radar to obtain this information, but several challenges must be overcome to develop a robust wa…
  • College: College of Engineering (COE)
  • Inventors: Johnson, Joel; Lyzenga, David; O'Brien, Andrew; Smith, Graeme
  • Licensing Officer: Wohlgamuth, Christopher

Carbon Dioxide Assisted Processing and Bonding of Polymer and Polymer Composites
TS-037400 — A novel method to bond polymer composites without the use of heat or organic solvents.
Application of either heat or organic solvents is critical to convert solid materials to fluids. For many applications, particularly biomedical products, high temperature and organic solvents may denature critical biomolecules. Residue of organic solvents may also cause severe contamination. In ad…
  • College: College of Engineering (COE)
  • Inventors: Lee, L; Tomasko, David; Yang, Yong; Zeng, Changchun
  • Licensing Officer: Wohlgamuth, Christopher

Referenceless and Frequency Independent Radio Reciever
TS-037378 — A radio receiver that operates without need for locally generated reference signals.
A radio frequency signal may typically consist of a single frequency carrier signal, modulated with some information signal. The purpose of a receiver is to extract the information signal from the carrier. This is commonly accomplished by mixing the received signal with one or more local reference…
  • College: College of Engineering (COE)
  • Inventors: Novak, Markus; Bojja venkatakrishnan, Satheesh; Volakis, John
  • Licensing Officer: Wohlgamuth, Christopher

Method to enhance light extraction efficiency in tunnel-injected III-Nitrate ultraviolet LEDs
TS-037365 — A novel method to enhance the transverse-electric and transverse-magnetic polarized light via relfective surfaces on top of a tunnel junction based LED structure.
III-Nitride ultraviolet light emitting diodes (UV LEDs) have a variety of promising applications, including sterilization and water purification. Currently, UV LEDs use an absorbing p-GaN top layer for hole injection, which reduces light extraction efficiency to lower than 20%. UV light emissions …
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Akyol, Faith; Jamal-Eddine, Zane; Zhang, Yuewei
  • Licensing Officer: Wohlgamuth, Christopher

Fabrication of Nanopapers and Nanoparticle Reinforced Polymeric Composites Using Vacuum-Assisted Layer-by-Layer Spraying Technique
TS-037364 — A method to combine advantages of fiber-reinforced plastics and nanocomposites to produce a low-cost, superior lightweight material.
Nanomaterials, more specifically nanoparticle reinforced composites, are one of the best solutions for most lightweight applications. Due to the dispersion and high aspect ratio of nanoparticles, lightweight polymer nanocomposites exhibit dimensional stability, heat and flame resistance, barrier p…
  • College: College of Engineering (COE)
  • Inventors: Lee, L; Guerra, Dante; Min, Yong Gang; Movva, Siva
  • Licensing Officer: Wohlgamuth, Christopher

A Control Architecture for Active Combustion Control in Conventional Diesel Engines
TS-037361 — A novel method to schedule diesel fueling parameters based on cylinder conditions.
For a diesel engine to produce a combustion process which results in a desired trade-off between emissions and fuel economy, the fuel injection parameters must account for the state of the air path system. This is typically accomplished by simultaneously determining the desired air path set point …
  • College: College of Engineering (COE)
  • Inventors: Midlam-Mohler, Shawn; Meyer, Jason; Sujan, Vivek; Yurkovich, Steve
  • Licensing Officer: Gooray, Arthur "Art"

Porous Thermoelectric Materials
TS-037351 — A formulation to increase the efficiency of thermoelectric materials by reducing density.
Thermoelectric effects enable direct conversion of thermal to electrical energy, which provides an alternative power generation and temperature conditioning. Although thermoelectric systems are environmentally friendly, the efficiency of thermoelectric devices cannot compete with current gold-stan…
  • College: College of Engineering (COE)
  • Inventors: Heremans, Joseph; Jaworski, Christopher
  • Licensing Officer: Gooray, Arthur "Art"

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