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Apoprotein manufacturing and methods for protein purification
TS-046794 — Methods of purifying proteins that can be used in various applications such as drug delivery and detoxification of byproducts of hemolysis.
Novel protein and apoprotein purification strategies are valuable tools with a wide variety of medical and research applications. While there are existing techniques for protein and apoprotein purification, some of these have flaws such as the use of harsh denaturants, highly flammable solvents, l…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Novel Phosphors for Solid-State Lighting Applications
TS-046581 — Novel halide perovskite phosphor that, when paired with blue LED light, creates warm white light without the need for high temperature ceramics in its production and does not contain rare-earth elements. It has several applications including solid-state lighting and white LEDs. The phosphors produce light with a natural appearance and extended excitation spectra.
Phosphors are used in a variety of products and for a variety of reasons. Halide perovskite phosphors, a specific type of phosphor, can be combined with light emitting diodes (LED) to create phosphor converted LEDs (pc-LED). The current technology has several shortcomings; deficiency in red and cy…
  • College: College of Arts & Sciences
  • Inventors: Woodward, Patrick; Gray, Matthew; Majher, Jackson
  • Licensing Officer: Hong, Dongsung

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

Field Effect Transistor for High Power Millimeter-Wave Applications
TS-042088 — Transistor structure with high breakdown voltage at high frequency operation
A new generation of high throughput, efficient communication networks and sensors can be enabled through the use of millimeter scale wave regimes. However, current semiconductor materials (such as AlGaN/GaN) have a reduction in breakdown voltage as operating frequency increases, which leads to low…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Wang, Caiyu; Xia, Zhanbo
  • Licensing Officer: Hong, Dongsung

A Generic Plug-in Jack-knife Accident Prevention System for Vehicle-Trailer Path Tracking Control
TS-041598 — A plug-in that predicts semi-truck jack-knifing and prevents it by saturating or overtaking steering control.
There is an increased consumer demand for autonomous vehicles which make driving safer and easier. Maneuvering and parking a semi-truck with a trailor attached is both dangerous and challenging. Autonomous semi-trucks can avoid one of the most prolific driving problems: jack-knifing, when a revers…
  • College: College of Engineering (COE)
  • Inventors: Hejase, Mohammad; Jing, Junbo; Bin Salamah, Yasser; Fiorentini, Lisa; Maroli, John; Ozguner, Umit
  • Licensing Officer: Hong, Dongsung

Hollow Valve for an Engine
TS-040523 — A coolant-free valve with a hollow vacuum cavity which reduces heat conduction and improves the efficiency of engines
Valves are essential components of engines that regulate intake of fuel and air and removal of combustion products. Solid valves conduct a significant amount of heat, which reduces the efficiency of the combustion process. Previous hollow valve designs fill the inner chamber with low-melting metal…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Ji-Cheng
  • Licensing Officer: Zinn, Ryan

Method for Connectorizing Superconducting NbTi Coaxial Cables
TS-040418 — A fast and inexpensive electroplating technique for producing a connector attachment matching the structural and electrical properties of standard coaxial cables for cryogenic applications.
Experiments performed at cryogenic temperatures much below the 4.2 K of liquid helium frequently require superconducting coaxial cables to efficiently transmit high frequency signals while minimizing heat transfer to the experiment’s cold stage. These cables are most often made of niobium-ti…
  • College: College of Arts & Sciences
  • Inventors: DeBry, Kyle; Lafyatis, Gregory
  • Licensing Officer: Hong, Dongsung

Separation of Small Hydrophobic Ligands from Proteins via Tangential Flow Filtration
TS-040370 — Novel strategy to separate hydrophobic ligands from proteins through the use of Tangential Flow Filtration in which efficiency, safety, and scalability are improved. Enhanced production of proteins in this native state holds promise both for improved research and biomedical applications.
Successfully isolating proteins in their non-liganded state (i.e. apoprotein form) allows for an in-depth study of proteins from a research perspective. From an application standpoint apoproteins hold tremendous promise as both potential therapeutics and as drug delivery vehicles given their natur…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Belcher, Donald; Palmer, Andre
  • Licensing Officer: Aanstoos, Megan

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Norris, Francis "Frank"

Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
  • College: College of Arts & Sciences
  • Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
  • Licensing Officer: Bartell, Cordellia

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