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Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Paschall, Christopher

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Hoffman, Joshua

Tethered Liposomal Nanoparticle (tLN) Microarray Chips Containing Molecular Probes for Simultaneous Cell Sorting and Bio Detection
TS-037347 — A simple, and efficient method for identifying intra-cellular biomarkers for the targeted treatment of disease.
Tethered Lipoplex Nanoparticle (TLN) microarray biochips simultaneously capture and identify extracellular vesicles (EV) RNA targets from human plasma or bodily fluids with or without EV isolation. Molecular detection probes, such as molecular beacons (MBs), identify specific micro RNA (miRNA) or …
  • College: College of Engineering (COE)
  • Inventors: Lee, L; Kwak, Kwang Joo; Lee, Andrew; Wu, Yun; Yu, Bo
  • Licensing Officer: Wohlgamuth, Christopher

Circulating Microvesicles Biomarkers and Molecular Targets in Disease
TS-035400 — Discovery of microvesicles containing microRNA from myeloid cells that can serve as biomarkers and molecular targets
In the last decade, scientific research showed exponential growth in publications on exosomes, cell-derived microvesicles. Many researchers are convinced that these tiny vesicles have unlimited potential in diagnostics and therapeutics, especially in oncology treatments. Microvesicles facilitate c…
  • College: College of Medicine (COM)
  • Inventors: Marsh, Clay; Hunter, Melissa; Ismail, Noura
  • Licensing Officer: Rumpal, Nidhi

Multichannel Polymer Chips for Rapid Multiplex Enzyme-Linked Immunosorbent Assay
TS-014978 — A more accurate, cost efficient and faster method to one of the most widely used diagnostic tests in the world.
The conventional Enzyme-Linked Immunosorbent Assay, or ELISA, is typically carried out in a 96-well or 384-well microliter plate. The method involves a series of mixing and washing steps, which are not only tedious and laborious, but which also often result in large errors and inconsistent outcome…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling; Huang, Wei-Cho
  • Licensing Officer: Paschall, Christopher

Mass Spectrometry Thrombotic Thrombocytopenic Purpura (TTP) Diagnostic Assay
TS-014915 — A rapid diagnostic test for Thrombotic Thrombocytopenic Purpura.
Thrombotic Thrombocytopenic Purpura (TTP) is a life-threatening microangiopathic thrombotic disorder that requires immediate diagnosis and emergency plasmapheresis therapy to prevent organ-system failure(s). Untreated TTP has a high mortality rate, but rapid diagnosis and plasma exchange therapy y…
  • College: College of Medicine (COM)
  • Inventors: Cataland, Spero; Bissell, Michael; Jin, Ming; Wu, Haifeng
  • Licensing Officer: Hoffman, Joshua

Real-Time Quadruplex Priming Amplification (QPA) for Nucleic Acid Amplification and Quantification
TS-014824 — An enhanced nucleic acid amplification system that is more efficient and cost-effective than conventional polymerase chain reaction methods.
The Need Identification of a particular nucleic acid is desirable in the use of diagnostic and forensic applications. However, often the target nucleic acid sequence may only be a small portion of the DNA or RNA in question so that it might be difficult to detect the presence of the target sequenc…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Flammang, Ann Marie
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