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Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network
TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.
Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
  • Licensing Officer: Norris, Francis "Frank"

Automated Detection of Tumor Budding in Colorectal Cancer
TS-039267 — A non-invasive and automated tumor budding image analysis system for colorectal cancer. This program can detect tumor buds in traditional H&E stained sections without the need for manual assessment.
Colorectal cancer is the third most commonly diagnosed cancer in the United States. With a survival rate of less than 65%, early detection and treatment are key factors in survival. Tumor budding, associated with higher tumor stage, lymph node metastasis, and decreased disease-free survival, has e…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Ahmad Fauzi, Mohammad Faizal; Chen, Wei "Wei"; Frankel, Wendy
  • Licensing Officer: Norris, Francis "Frank"

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Paschall, Christopher

Methylated Peptides Derived from Tau Protein and Their Antibodies as Diagnostic and Therapeutic Reagents for Alzheimer's Disease
TS-037626 — A diagnostic to provide more swift and reliant detection of Alzheimer's disease by monitoring the chemical modification of tau proteins in bodily fluids.
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia worldwide. While there are some indications of genetic predisposition, the etiology of the disease is primarily unknown, but it does progress with age. Diagnosis of the disease is critical at…
  • College: College of Medicine (COM)
  • Inventors: Kuret, Jeffrey; Funk Johnson, Kristen; Yang, Austin
  • Licensing Officer: Flammang, Ann Marie

Nanopump Separation Device and Method
TS-037584 — A device for separating macromolecules in a solution of macromolecules having different molecular sizes
Many clinical and research applications involve separation of specific biological molecules, such as nucleic acids and proteins, for further analysis and characterization. A complex biological system can only be understood after each component has been separately analyzed, and proteins must be pur…
  • College: College of Engineering (COE)
  • Inventors: Hansford, Derek; Walczak, Robbie
  • Licensing Officer: Hoffman, Joshua

Tethered Liposomal Nanoparticle (tLN) Microarray Chips Containing Molecular Probes for Simultaneous Cell Sorting and Bio Detection
TS-037347 — A simple, and efficient method for identifying intra-cellular biomarkers for the targeted treatment of disease.
Tethered Lipoplex Nanoparticle (TLN) microarray biochips simultaneously capture and identify extracellular vesicles (EV) RNA targets from human plasma or bodily fluids with or without EV isolation. Molecular detection probes, such as molecular beacons (MBs), identify specific micro RNA (miRNA) or …
  • College: College of Engineering (COE)
  • Inventors: Lee, L James; Kwak, Kwang Joo; Lee, Andrew; Wu, Yun; Yu, Bo
  • Licensing Officer: Wohlgamuth, Christopher

Circulating Microvesicles Biomarkers and Molecular Targets in Disease
TS-035400 — Discovery of microvesicles containing microRNA from myeloid cells that can serve as biomarkers and molecular targets
In the last decade, scientific research showed exponential growth in publications on exosomes, cell-derived microvesicles. Many researchers are convinced that these tiny vesicles have unlimited potential in diagnostics and therapeutics, especially in oncology treatments. Microvesicles facilitate c…
  • College: College of Medicine (COM)
  • Inventors: Marsh, Clay; Hunter, Melissa; Ismail, Noura
  • Licensing Officer: Rumpal, Nidhi

Multichannel Polymer Chips for Rapid Multiplex Enzyme-Linked Immunosorbent Assay
TS-014978 — A more accurate, cost efficient and faster method to one of the most widely used diagnostic tests in the world.
The conventional Enzyme-Linked Immunosorbent Assay, or ELISA, is typically carried out in a 96-well or 384-well microliter plate. The method involves a series of mixing and washing steps, which are not only tedious and laborious, but which also often result in large errors and inconsistent outcome…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling; Huang, Wei-Cho
  • Licensing Officer: Paschall, Christopher

Mass Spectrometry Thrombotic Thrombocytopenic Purpura (TTP) Diagnostic Assay
TS-014915 — A rapid diagnostic test for Thrombotic Thrombocytopenic Purpura.
Thrombotic Thrombocytopenic Purpura (TTP) is a life-threatening microangiopathic thrombotic disorder that requires immediate diagnosis and emergency plasmapheresis therapy to prevent organ-system failure(s). Untreated TTP has a high mortality rate, but rapid diagnosis and plasma exchange therapy y…
  • College: College of Medicine (COM)
  • Inventors: Cataland, Spero; Bissell, Michael; Jin, Ming; Wu, Haifeng
  • Licensing Officer: Hoffman, Joshua

Prognostic Indicators of Canine Lymphoid Neoplasia using Tumor-derived Plasma DNA
TS-014831 — Prognostic Indications of Canine Lymphoid Neoplasia using plasma DNA assays.
Dogs, like humans, are susceptible to development of abnormal growths or cancers. Improved veterinary medical care and diagnostic techniques have enabled a longer lifespan for dogs; however, older populations also have higher incidence rates of canine cancers. This proliferation in incidence of ca…
  • College: College of Veterinary Medicine
  • Inventors: Rush, Laura
  • Licensing Officer: Rumpal, Nidhi

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