Novel Natural Product Derivatives Treating Chronic Metabolic and Inflammatory Diseases
TS-075260 — Problem
Type 2 diabetes and related metabolic disorders affect hundreds of millions of patients and are frequently accompanied by chronic inflammation, which accelerates disease progression and complications. Existing antidiabetic therapies often fail to adequately address inflammatory pathways and…
- College: College of Pharmacy (COP)
- Inventors: Carcache de Blanco, Esperanza; Anaya Eugenio, Gerardo David; Eggers, Nicole
- Licensing Officer: He, Panqing
Bidirectional modulation of liver sinusoidal clearance system
TS-075188 — Problem
The liver sinusoidal clearance system (LSCS) is responsible for eliminating the majority of circulating macromolecular waste, inflammatory mediators, toxins, and therapeutic agents. Excessive hepatic clearance limits the efficacy of therapies, including chemotherapies and vaccines. In contr…
- College: College of Education & Human Ecology
- Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
- Licensing Officer: Bhatti, Hamid
Gene therapy for adipose neuropathy
TS-075160 — Problem
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart and subcutaneous white adipose tissue (scWAT). It is mostly associated with diabetes, obesity, aging, and chemotherapy. Affecting 10-20% of U.S. adults aged 50-70, PN is…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
Treating Diabetes, Obesity, and Cardiovascular Disease by Reprogramming Skin
TS-065789 — Using tissue nano-transfection to reprogram skin cells to treat diabetes, obesity and/or cardiovascular health
The incidence of obesity and diabetes is skyrocketing, leading to chronic inflammatory conditions such as cardiovascular disease, autoimmune diseases, liver diseases, and cancer. Cardiovascular disease (CVD) is the leading cause of death across the US and worldwide and affects almost half of all ad…
- College: College of Medicine (COM)
- Inventors: Gallego Perez, Daniel; Higuita Castro, Natalia; Sen, Chandan
- Licensing Officer: Willson, Christopher
Selective Estrogen Receptor Beta Agonists
TS-062680 — According to the American Cancer Society, breast cancer is the most common cancer for women in the US, except for skin cancer. It comprised about 30% of all new female cancers each year. While breast cancer death rates have decreased over the last several decades, it remains the second leading cause…
- College: College of Pharmacy (COP)
- Inventors: Bennett, Chad; Wang, Dasheng
- Licensing Officer: Taysavang, Panya
Novel Natural Product Derivatives Targeting Chronic Diseases
TS-050220 — Novel natural products and derivatives thereof that exhibit potent in vitro and in vivo activity
The Need
Metabolic disorders such as type 2 diabetes are a major health concern that have impacted hundreds of millions of adults worldwide. Current pharmaceutical therapies for type 2 diabetes have been associated with adverse reactions including weight gain and increased risk of infection, liver …
- College: College of Pharmacy (COP)
- Inventors: Carcache de Blanco, Esperanza; Anaya Eugenio, Gerardo David; Eggers, Nicole
- Licensing Officer: He, Panqing
Laparoscopic Circular Stapler Device with a Collapsible Anvil
TS-014834 — An improved device for surgical end-to-end anastomosis, a procedure common in Roux-en-Y gastric bypass
Roux-en-Y laparoscopic gastric bypass is regarded as the ‘gold-standard-of-care’ for morbidly obese patients, classified as individuals with a body mass index (BMI) > 40. During the procedure, the surgeon creates a small hole, called an anastomosis, to reconnect the newly created st…
- College: College of Engineering (COE)
- Inventors: Nelson, Mark; Hoffman, Joshua; Hogrebe, Nathaniel; Liu, Xiaoli; Scheitlin, Christopher
- Licensing Officer: Zinn, Ryan
