Available Technologies
# of Displayed Technologies: 7 / 7
Applied Category Filter (Click To Remove): Lipid/Liposomal-Based & Exosomes/Extracellular Vesicles
Fibroblast-specific LNPs delivering A20 mRNA to treat idiopathic pulmonary fibrosis (IPF)
TS-075175 — Problem
Idiopathic pulmonary fibrosis (IPF) is a chronic disease where activated fibroblasts mediate the abnormal accumulation of extracellular matrix (ECM) in the lung interstitial space, leading to progressive impairment of pulmonary function. Current IPF therapies are associated with significant…
- College: College of Pharmacy (COP)
- Inventors: Dong, Yizhou; Kang, Diana; Wang, Chang; Yan, Jingyue
- Licensing Officer: He, Panqing
Novel extracellular vesicles loaded with anti-inflammatory agents for the treatment of pulmonary diseases
TS-075161 — Problem
Acute and chronic pulmonary inflammation conditions, such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI) and asthma, remain a significant healthcare challenge with high mortality rates, long-term morbidity and a substantial economic burden due to prolonged hospital s…
- College: College of Medicine (COM)
- Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
- Licensing Officer: Willson, Christopher
Novel Therapeutic Approach to Treating Painful Musculoskeletal Disorders
TS-065684 — Non-viral gene therapy for minimally invasively treating painful musculoskeletal disorders
Painful musculoskeletal disorders like intervertebral disc (IVD) degeneration associated with chronic low back pain (DBP) present a significant socio-economic burden worldwide.
The Need
Current treatments for painful musculoskeletal disorders offer only temporary relief or invasive surgical proce…
- College: College of Engineering (COE)
- Inventors: Purmessur Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
- Licensing Officer: Willson, Christopher
Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — , 2018-345 Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need
Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
- College: College of Medicine (COM)
- Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
- Licensing Officer: Willson, Christopher
Stealth liposomes with greater stability for improved drug delivery
TS-048888 —
Liposome drug delivery systems play a significant role in the formulation of new therapies. These liposome-encapsulated drugs are used to treat a wide range of diseases such as cancer, influenza, and hepatitis. While endogenous liposomes are recognized by the mononuclear phagocyte system and clear…
- College: College of Arts and Sciences (COAAS)
- Inventors: Bong, Dennis
- Licensing Officer: Panic, Ana
Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries.
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an arteriovenous (AV) fistula used in hemodialysis access has been estimated at $15,000/year. In bypass and AV fistula…
- College: College of Medicine (COM)
- Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
- Licensing Officer: Taysavang, Panya
Biomimetic Nanoplatform to Deliver Anti-Restenotic Therapeutics
TS-036654 — A stent-free delivery platform for reducing arterial plaques.
Cardiovascular disease is the leading cause of death in the United States, resulting in more than 600,000 deaths and a significant contributor to overall healthcare costs. Over 28 million Americans are diagnosed with heart disease and contribute more than $30 billion in healthcare-related expenses. …
- College: College of Medicine (COM)
- Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Urabe, Go; Wang, Bowen
- Licensing Officer: Bhatti, Hamid
