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Novel Efficient Butanol Production without CO2 Emission
TS-068795 — The Need Renewable energy resources have gained global interest due to environmental issues, climate change, oil price and supply volatility, and decreasing nonrenewable fossil fuel sources. Butanol is a biofuel alternative that can provide a higher heating value, lower volatility, polarity, cor…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Randhawa, Davinder

Fungal Biocontrol Agents for Sustainable Resistance Management of Soybean Cyst Nematode Populations
TS-068701 — Novel fungal antagonists that suppress soybean cyst nematode (SCN) populations offer a natural solution that improves soil health and integrates into existing farming practices.
Background The soybean cyst nematode (SCN) is the leading cause of yield loss in global soybean production, resulting in billions of dollars in economic damage annually. Traditional management strategies, including crop rotation and resistant cultivars are becoming less effective as SCN adapts and…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Medina Lopez, Melanie; Benitez Ponce, Maria Soledad; Lopez Nicora, Horacio
  • Licensing Officer: Panic, Ana

Sustainability-Aware Management of Autonomous Mobile Robot (AMR) Fleets
TS-068477 — The Need Autonomous Mobile Robots (AMRs) are critical to modern, highly automated environments, operating 24/7 to optimize tasks, increase throughput, and meet demanding operational requirements. However, most task allocation and charging solutions focus solely on maximizing performance metrics like…
  • College: College of Engineering (COE)
  • Inventors: Brocanelli, Marco
  • Licensing Officer: Randhawa, Davinder

A Method for Accurate Cross Band Channel Prediction
TS-068476 — The Need Modern wireless networks, including 5G and future 6G systems, rely heavily on accurate channel prediction to ensure efficient and reliable communication. Frequency Domain Duplexing (FDD) systems face challenges in accurately predicting downlink channels from uplink channels, particularly in…
  • College: College of Engineering (COE)
  • Inventors: Banerjee, Avishek; Parthasarathy, Srinivasan; Srinivasan, Kannan
  • Licensing Officer: Randhawa, Davinder

A Scalable Method for Minimizing Beam-Training Overhead in mmWave Communications
TS-068475 — The Need As mmWave technology becomes the backbone of 5G and other advanced communication systems, the demand for fast, reliable, and scalable beamforming solutions has surged. Traditional beam-training methods are computationally intensive and time-consuming, leading to delays in establishing high-…
  • College: College of Engineering (COE)
  • Inventors: Srinivasan, Kannan; Chen, Wei-Han; Liu, Xin; Parthasarathy, Srinivasan
  • Licensing Officer: Randhawa, Davinder

Passive Optical-to-RF Conversion for Secure Eavesdropping on Optical Wireless Communication Systems
TS-068474 — The Need As Optical Wireless Communication (OWC) systems become increasingly prevalent, there is a growing demand for innovative signal conversion techniques that enhance communication capabilities while addressing security vulnerabilities. Conventional methods of optical-to-RF signal conversion rel…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xin; Song, Guanqun; Zhu, Ting
  • Licensing Officer: Randhawa, Davinder

Method for developing thick β-Ga2O3 films on (001) Ga2O3 substrates using (AlxGa1-x)2O3 buffer layer
TS-068473 — The Need β-Ga2O3 has spurred substantial interest in semiconductors and transistors in high-power/high-frequency electronics and ultraviolet optoelectronics. However, there exists a critical challenge of growing high-quality, thick layers of gallium oxide (Ga2O3) on Ga2O3 substrates. Existing …
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Meng, Lingyu; Yu, Dong Su
  • Licensing Officer: Randhawa, Davinder

Self-Calibration Technique for mmWave Antenna Arrays Based on Everyday Communication Behaviors
TS-068472 — The Need The increasing adoption of mmWave technologies in 5G, IoT, and other advanced communication networks highlights a critical need for cost-effective, efficient, and scalable antenna calibration solutions. Traditional calibration methods rely on expensive laboratory setups and specialized equi…
  • College: College of Engineering (COE)
  • Inventors: Srinivasan, Kannan; Chen, Wei-Han; Liu, Xin
  • Licensing Officer: Randhawa, Davinder

Organizational Innovation Accelerator Program
TS-068445 — In today’s fast-paced global economy, organizations must continually adapt to remain competitive. Yet, systemic barriers—both social and technical—frequently hinder innovation. High production pressure, limited opportunities for professional development, and reliance on third-par…
  • College: College of Engineering (COE)
  • Inventors: Maguire, Laura; Rayo, Michael
  • Licensing Officer: Zinn, Ryan

Joint Activity Testing (JAT): A Testing & Evaluation Methodology for Human-Machine Teams
TS-068443 — In high-stakes industries, the integration of humans and advanced automation systems demands evaluation methods that reliably predict performance under varying challenges. Current testing methods often focus on individual components, failing to assess how human-machine teams operate as a unit, par…
  • College: College of Engineering (COE)
  • Inventors: Morey, Dane; Rayo, Michael
  • Licensing Officer: Zinn, Ryan

Vision System Using MDP-Based Tracking for Automated Dimensional Analysis
TS-068440 — Accurate measurement of physical attributes, such as dimensions, alignments, and surface features, is essential for ensuring quality and consistency across industries. Traditional measurement methods, often reliant on manual tools and human oversight, are time-intensive, prone to errors, and lac…
  • College: College of Engineering (COE)
  • Inventors: Allen, Theodore; Rodriguezbuno, Ramiro; Zhang, Yifei
  • Licensing Officer: Zinn, Ryan

A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Panic, Ana

Noninvasive Rapid Radiation Exposure Assay
TS-068290 — The Need Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require invasive procedures and may not detect exposure at lower dose ranges. …
  • College: College of Arts & Sciences
  • Inventors: Schultz, Zachary; Jacob, Naduparambil; Morder, Courtney; Witte, Spencer
  • Licensing Officer: Panic, Ana

Enzymatic Inhibitor for Control of Enteric Methane Emission by Ruminants
TS-068275 — The small molecule inhibitor targets methanogenic archaea in the rumen, offering a novel and sustainable solution to significantly reduce methane emissions from ruminants. Background Atmospheric methane levels have doubled over the past century, driven largely by emissions from ruminant…
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat
  • Licensing Officer: Panic, Ana

RAFT Agents for Controlled Radical Polymerization of Biofunctionalized Polymeric Materials
TS-068081 — These RAFT agents enable synthesis of novel polymer materials with enhanced biocompatibility and tailored functionality, suited for a wide range of biomedical applications.
Background The growing demand for biofunctionalized polymer materials in fields such as drug delivery and diagnostics requires precise control over polymer properties. However, current reagents for Reversible Addition Fragmentation chain Transfer (RAFT) polymerization struggle with achieving the ne…
  • College: College of Arts & Sciences
  • Inventors: Kulkarni, Anuja; Watkins, Davita
  • Licensing Officer: Panic, Ana

Wearable Coils for Monitoring Human Body Kinematics
TS-067943 — Monitoring human physiological functions and performance during real-time activities is becoming increasingly popular in sporting and healthcare environments. Many studies now suggest that the quantitative evaluation of kinetic parameters, joint range of motion, heart rate, and breathing rate can be…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Mishra, Vigyanshu
  • Licensing Officer: Randhawa, Davinder

Non-Contact Magnetocardiography for Measuring Cognitive Workload
TS-067810 — Work environments and other brain-intensive activities impose high demands on the cognitive and cerebral resources required to process vast amounts of information. This high demand can expose individuals to cognitive overload, which can be dangerous for their health and lead to errors and accidents.…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Zhu, Keren
  • Licensing Officer: Randhawa, Davinder

A Non-Destructive Quality Control Test for Organic Coatings in Food Can Applications
TS-067800 — This technology is an electrical impedance test (EIT) for evaluating the integrity of the enamel coating found on the interior surface of canned foods.
Fruits and vegetables used in canning are picked at peak freshness, ensuring the best flavor and nutrient quality. Because canning preserves nutrients, canned foods can be as nutritious as fresh and frozen foods. The amount of minerals, fat-soluble vitamins, protein, fat, and carbohydrates remains r…
  • College: College of Engineering (COE)
  • Inventors: Frankel, Gerald "Jerry"; Kosanam, Koushik
  • Licensing Officer: Zinn, Ryan

Neonatal Blood Vessel Locator for Vascular Access Procedures
TS-067796 — A handheld device for identifying preterm blood vessels in neonatal ICU.
Over 300,000 preterm births in the United States occur annually, representing 10.5% of all live births. Most preterm births occur spontaneously, but some result from medical conditions like infections or pregnancy complications requiring early labor induction or cesarean delivery. Common causes of p…
  • College: College of Engineering (COE)
  • Inventors: Metzler, Sandra; Bresolin, Alejandro; Crawford, Mackenzie; Fernandes, Siddharth; Hardin, Rene; Patel, Aarti; Richards, Hannah; Trainor, Dylan
  • Licensing Officer: Zinn, Ryan

Methods to produce high purity tritium gas
TS-067793 — The technology is a device and method for producing high purity tritium gas by irradiating a lithium composition within a gas cell that selectively allows tritium to diffuse while blocking other byproducts, ensuring efficient and direct collection of pure tritium without extensive purification. This system is designed to enhance the purity, efficiency, and scalability of tritium production for various industrial and research applications.
The production of high purity tritium gas is critical for applications in nuclear fusion, radioluminescent devices, and scientific research. Current methods for tritium production often result in contaminants like helium and other gases, requiring additional purification processes that are costly …
  • College: College of Engineering (COE)
  • Inventors: Cao, Lei Raymond; Van Zile, Matthew
  • Licensing Officer: Zinn, Ryan

Computational Design of Experiment Framework for Processing of Metal Alloys
TS-067792 — A software tool for optimizing the manufacturing process for metal alloys.
Metallic alloys are composed of a homogeneous mixture of two or more metals or of metals and nonmetal or metalloid elements to provide specific characteristics or structural properties. Alloys are used in many applications, such as aircraft, offshore drilling, automobiles, and others. Obtaining t…
  • College: College of Engineering (COE)
  • Inventors: Alexandrov, Boian; Forquer, Matthew; Jang, Eun; Luo, Yuxiang; Stewart, Jeffrey
  • Licensing Officer: Zinn, Ryan

A device for improving the breakdown performance of gallium oxide semiconductors
TS-067551 — Gallium Oxide (Ga2O3) is an inorganic compound with semi-conductivity properties (e.g., a large bandgap) that can be used for developing power electronics, UV photodetectors, solar cells, and sensors. βeta-Ga2O3, a polymorph, has a distinct advantage over other semiconductors that have high cri…
  • College: College of Engineering (COE)
  • Inventors: Dheenan, Ashok; Dhara, Sushovan; Rajan, Siddharth
  • Licensing Officer: Zinn, Ryan

Optimal and Pure Leaf Classification Trees for Machine Learning (ML) Decision-Making
TS-067550 — A method to improve the performance and accuracy of ML-based decision trees.
Decision trees are popular machine learning (ML) methods used in classification and regression problems, and they have numerous applications in the real world. Various industries use decision trees to help decide strategies, investments, and operations. In addition, they are used in healthcare to he…
  • College: College of Engineering (COE)
  • Inventors: Allen, Theodore; Arrey, Evelyn; Booth, Matthew; Liu, Enhao; Mashayekhi, Medhi
  • Licensing Officer: Zinn, Ryan

Method of repurposing spacecraft dust as an agricultural material
TS-067535 — The Need In future decades, more people than ever will be spending time in space. Current crop production systems onboard spacecraft are not self-sustainable, relying on fertilizer and substrate materials that must be launched from Earth. These resupply missions can cost thousands of dollars per po…
  • College: College of Engineering (COE)
  • Inventors: Nastasi, Nicholas; Dannemiller, Karen
  • Licensing Officer: Ashouripashaki, Mandana

Unlocking Hidden Opportunities: The Power of Multi-Solution Spatial Aggregation
TS-067434 — The Need Spatial aggregation is crucial in numerous industries where data from low-level spatial units, such as census blocks, must be grouped into larger, meaningful regions. Traditional approaches often struggle with the computational complexity of these tasks and tend to focus on finding a singl…
  • College: College of Arts & Sciences
  • Inventors: Xiao, Ningchuan
  • Licensing Officer: Dahlman, Jason "Jay"

Reed Held: Precision Practice Tool for Oboists
TS-067289 — The Need Oboists often struggle with fundamental elements of their playing, such as pitch accuracy, phrasing, and response, due to the complexity of managing the instrument as a whole. Traditional practice methods may not allow for the isolated focus necessary to correct these specific issues. Ther…
  • College: College of Arts & Sciences
  • Inventors: Held, Abby
  • Licensing Officer: Panic, Ana

Direct Analysis of Air and Water Sensitive Material by In-Chamber Ionization Mass Spectrometry
TS-067160 — The Need Due to the unparalleled ability of Mass spectrometry (MS) to identify and quantify substances at the molecular level it is an indispensable tool in various industries, from pharmaceuticals and forensics to environmental monitoring and materials science. However, the power of MS is often hi…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Hadad, Christopher; Lalisse, Remy; Sahraeian, Taghi; Wu, Yiying; Zheng, Jingfeng
  • Licensing Officer: Panic, Ana

Co-Axial Contained Electrospray Ionization Platform for Mass Spectrometry
TS-067158 — The Need Mass spectrometry (MS) is used across a wide range of applications for detection of various chemical analytes such as drug metabolites, pesticides, food adulterants, and natural product extracts. Recent developments have transformed MS into an all-purpose technique for in-situ and real-tim…
  • College: College of Arts & Sciences
  • Inventors: Badu-Tawiah, Abraham; Burris, Benjamin "Ben"; Grooms, Alex; Heiss, Derik; Kulyk, Dmytro
  • Licensing Officer: Panic, Ana

AIDRIN (AI Data Readiness Inspector)
TS-067116 — AIDRIN (AI Data Readiness Inspector) is a system designed to comprehensively evaluate datasets through a diverse range of metrics, giving an overall perspective on their readiness for AI applications.
In the contemporary digital landscape, the explosive growth in data generation has created a pressing need for efficient and scalable database systems. Traditional databases struggle with the increasing volume, variety, and velocity of data, leading to performance bottlenecks, high operational cos…
  • College: College of Engineering (COE)
  • Inventors: Byna, Suren; Hiniduma, Kaveen
  • Licensing Officer: Zinn, Ryan

Endoscopic additive manufacturing of conductors and wireless implants
TS-067045 — The Need Wireless implants with integrated antennas are highly desirable for diagnostic, therapeutic, and monitoring applications due to their ability to communicate directly with external devices. However, the need for major surgical incisions to implant these devices poses significant risks, incl…
  • College: College of Engineering (COE)
  • Inventors: Kiourti, Asimina; Dontha, Balaji; Hoelzle, David; Li, Jinghua; Moulod, Mohammad
  • Licensing Officer: Randhawa, Davinder

Novel Quantitative Method to Detect Mold Growth in Buildings
TS-066963 — The Need Exposure to mold in homes costs billions of dollars every year. Exposure is particularly harmful to the 8% of the United States population that suffers from asthma; a leading cause of disability in children. Currently, odor, visible mold growth, and dampness are the best indicators of mold…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Balasubrahmaniam, Neeraja; Bope, Ashleigh
  • Licensing Officer: Ashouripashaki, Mandana

Dust Analysis: A Novel Approach to Monitoring Viral Spread
TS-066962 — The Need Viral disease surveillance (e.g. influenza, SARS-CoV-2) in high-risk settings faces several challenges, such as asymptomatic carriers, incomplete reporting, resource limitations, and delayed diagnosis of traditional swab test methods. These challenges could allow a virus to silently spread…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Faith, Seth; Hull, Natalie; Nastasi, Nick; Renninger, Nicole
  • Licensing Officer: Ashouripashaki, Mandana

Smartphone Detection Kit for Airborne Formaldehyde and Allergens
TS-066960 — The Need Indoor air can be polluted by various sources, including building materials, furniture, cleaning products, and even people. Exposure to these resulting contaminants and allergens can lead to a variety of health problems, such as respiratory irritation, allergies, and even cancer. It is cur…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Parquette, Jonathan; Qin, Rongjun
  • Licensing Officer: Ashouripashaki, Mandana

Color Correction System for Accurate Colorimetric Smartphone Measurements
TS-066957 — The Need Colorimetric tests and remote image analysis are used in a wide range of industrial and medical applications. Digital image-based measurements made with smartphones are a promising platform to quantify colors at low cost, but suffer from inconsistency and errors caused by lens quality, sen…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Panescu, Jenny; Qin, Rongjun; Song, Shuang; Zhang, Guixiang
  • Licensing Officer: Ashouripashaki, Mandana

Unveiling the Nanoscale: Breakthrough Analytical Speed of Real-Time Super-Resolution Microscopy and Beyond
TS-066926 — This Ohio State University software innovation offers groundbreaking analytical speed and automation of Single-Molecule Localization Microscopy (SMLM) as well as analysis of 3D data and images extending beyond the field of microscopy. Our technology offers real-time spatial analysis in continuous and discrete space, enabling unprecedented speed and efficiency in data processing that translates into faster decision-making, high-throughput screening capabilities, and broad applicability beyond traditional microscopy.
Single-molecule localization microscopy (SMLM) describes a family of fast-evolving, powerful imaging techniques that dramatically improve spatial resolution over standard, diffraction-limited microscopy techniques and can image biological structures at the molecular scale. SMLM can now be performe…
  • College: College of Engineering (COE)
  • Inventors: Soltisz, Andrew; Veeraraghavan, Rengasayee
  • Licensing Officer: Zinn, Ryan

Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Advanced Sensor Housing for Environmental Monitoring in Precision Agriculture and Beyond
TS-066793 — The Need In agriculture, the accurate measurement of gasses such as nitrous oxide (N2O) and nitrogen oxides (NOx) is crucial for optimizing fertilizer use, minimizing greenhouse gas emissions, and reducing air pollution. Current monitoring technologies are often expensive, complex, and not suitable…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Khanal, Sami; Bevers, Noah; Shearer, Scott; Tkach, Chris
  • Licensing Officer: Dahlman, Jason "Jay"

Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

Biofilm Detachment Monitoring for Enhanced Oral Health Solutions
TS-066772 — The Need Biofilms, particularly dental plaque-biofilms, are communities of microorganisms encased in a slimy extracellular polymeric substance (EPS) that adhere to surfaces or neighboring microorganisms. These biofilms are responsible for various infectious diseases, including oral diseases such as…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Gloag, Erin
  • Licensing Officer: Willson, Christopher

Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 — Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
  • College: College of Medicine (COM)
  • Inventors: Al Tarawneh, Rawan
  • Licensing Officer: Willson, Christopher

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